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Gene Review

Neu3  -  sialidase 3 (membrane sialidase)

Rattus norvegicus

Synonyms: Ganglioside sialidase, Membrane sialidase, N-acetyl-alpha-neuraminidase 3, Sialidase-3
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Disease relevance of Neu3


High impact information on Neu3

  • The remainder of the membrane sialidase-susceptible sialic acid was released in a second, slower stage [2].
  • The results of this study indicate that both glycolipid- and glycoprotein-bound sialic acid in the synaptic membrane are releasable in situ by the action of the intrinsic synaptic membrane sialidase, and they suggest that this enzyme may act to modulate the physical properties of the membrane [2].
  • Chronic ethanol also increased the concentration of the rat brain plasma membrane sialidase protein relative to that of glyceraldehyde-3-phosphate dehydrogenase by 2.4-, 1.62- and 1.51-fold in the total brain homogenate, myelin and synaptosomal membrane fractions, respectively [4].
  • Thus, our studies clearly show that chronic ethanol induced deglycosylation of brain gangliosides is in part, due to specific up-regulation of plasma membrane sialidase in the myelin and synaptosomal membrane fractions of the brain [4].
  • In an attempt to understand the possible mechanism of chronic ethanol-induced generation of asialoconjugates in the brain and consequent behavioral abnormalities, we have studied the effects of chronic ethanol feeding to rats on the plasma membrane sialidase status in the various subcellular fractions of the brain [4].

Anatomical context of Neu3


Associations of Neu3 with chemical compounds


Other interactions of Neu3


Analytical, diagnostic and therapeutic context of Neu3


  1. Distinguishing mammalian sialidases by inhibition kinetics with novel derivatives of 5-acetamido-2,6-anhydro-3,5-dideoxy-D-glycero-D-galacto-non-2-enonic acid, an unsaturated derivative of N-acetylneuraminic acid. Warner, T.G., Louie, A., Potier, M., Ribeiro, A. Carbohydr. Res. (1991) [Pubmed]
  2. Action of intrinsic sialidase of rat brain synaptic membranes on membrane sialolipid and sialoprotein components in situ. Yohe, H.C., Rosenberg, A. J. Biol. Chem. (1977) [Pubmed]
  3. Differential functional relevance of a plasma membrane ganglioside sialidase in cholinergic and adrenergic neuroblastoma cell lines. von Reitzenstein, C., Kopitz, J., Schuhmann, V., Cantz, M. Eur. J. Biochem. (2001) [Pubmed]
  4. Effects of chronic ethanol administration on the activities and relative synthetic rates of myelin and synaptosomal plasma membrane-associated sialidase in the rat brain. Azuine, M.A., Patel, S.J., Lakshman, M.R. Neurochem. Int. (2006) [Pubmed]
  5. Chronic ethanol increases ganglioside sialidase activity in rat leukocytes, erythrocytes, and brain synaptosomes. Marmillot, P., Rao, M.N., Liu, Q.H., Lakshman, M.R. Alcohol. Clin. Exp. Res. (1999) [Pubmed]
  6. Cerebellar granule cells in culture exhibit a ganglioside-sialidase presumably linked to the plasma membrane. Riboni, L., Prinetti, A., Bassi, R., Tettamanti, G. FEBS Lett. (1991) [Pubmed]
  7. Effects of OK-432 activation on the sialidase activities of rat peritoneal macrophages. Sagawa, J., Miyagi, T., Tsuiki, S. Tohoku J. Exp. Med. (1990) [Pubmed]
  8. Chronic ethanol consumption upregulates the cytosolic and plasma membrane sialidase genes, but down regulates lysosomal membrane sialidase gene in rat liver. Garige, M., Azuine, M.A., Lakshman, M.R. Metab. Clin. Exp. (2006) [Pubmed]
  9. Differential effect of various inhibitors on four types of rat sialidase. Miyagi, T., Hata, K., Hasegawa, A., Aoyagi, T. Glycoconj. J. (1993) [Pubmed]
  10. Chronic ethanol feeding controls the activities of various sialidases by regulating their relative synthetic rates in the rat liver. Azuine, M.A., Patel, S.J., Lakshman, M.R. Metab. Clin. Exp. (2005) [Pubmed]
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