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Gene Review

ISOC1  -  isochorismatase domain containing 1

Homo sapiens

Synonyms: CGI-111, Isochorismatase domain-containing protein 1
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Disease relevance of ISOC1

  • Hypoxia also increased basal [Ca2+]cyt, the amount of CCE produced by store depletion with cyclopiazonic acid, and the amplitude of SOC-mediated currents (ISOC) [1].
  • Hepatic ischemia and reperfusion injury model was established and whole cell patch-clamp techniques were used to investigate the effects of 2-APB on Isoc [2].

High impact information on ISOC1

  • Essential control of an endothelial cell ISOC by the spectrin membrane skeleton [3].
  • F-actin configuration is an important determinant of channel function, although the nature of interaction between the cytoskeleton and ISOC channels is unknown [3].
  • TRPV6 cDNA transfection of LNCaP cells restored recombinant ITRPV6, which can be distinguished from ISOC by the mechanism of activation, the voltage dependence of monovalent currents in the absence of external divalent cations, and the changes in Ca2+ current densities due to different membrane potentials [4].
  • In addition, ISOC was not affected by antiandrogen or 1,25-dihydroxyvitamin D3 treatment of LNCaP cells, which up-regulates TRPV6 gene expression, or by androgen treatment, which has the opposite effect [4].
  • The data demonstrate that internal Ca2+ store depletion-activated Ca2+ current (ISOC) in this salivary cell line is regulated by a Ca2+-dependent feedback mechanism involving a staurosporine-sensitive protein kinase and the intracellular Ca2+ pump [5].

Biological context of ISOC1

  • Results indicated that ISOC performance is related to fitness components identified as important in the performance of military tasks, namely, aerobic and anaerobic power, muscular strength and endurance, and body composition [6].
  • The results showed that ischemia/reperfusion injuries could significantly reduce hepatocellular viability and further increase Isoc in hepatocytes and 2-APB (20, 40, 60, 80, 100 micromol/L,) produced a concentration-dependent decrease of Isoc with IC50 value of 64 [2].

Anatomical context of ISOC1

  • Performance scores on the ISOC were found to be significantly (p less than 0.01) and positively correlated to maximal aerobic power (MAP), muscular strength and endurance and anaerobic lactic power, and negatively correlated to indices of body fat [7].

Associations of ISOC1 with chemical compounds

  • Whereas Vfmax and KmISOCm (where ISOC is isocitrate) were pH-independent, the Km for NADP was pH-dependent for both isozymes [8].
  • On the other hand, depletion of Ca2+ stores by different maneuvers, such as the application of ATP, thapsigargin or A23187, or dialysis of the cells with inositol-1,4,5-trisphosphate activated another type of nonselective current which was identified as store-operated Ca(2+)-permeable current (ISOC) [9].

Analytical, diagnostic and therapeutic context of ISOC1

  • In the present study, we used whole-cell perforated patch-clamp techniques to measure ISOC (store-operated current) corresponding to CCE in A7r5 cells [10].


  1. Hypoxia increases AP-1 binding activity by enhancing capacitative Ca2+ entry in human pulmonary artery endothelial cells. Fantozzi, I., Zhang, S., Platoshyn, O., Remillard, C.V., Cowling, R.T., Yuan, J.X. Am. J. Physiol. Lung Cell Mol. Physiol. (2003) [Pubmed]
  2. Effects of 2-APB on store-operated Ca2+ channel currents of hepatocytes after hepatic ischemia/reperfusion injury in rats. Huang, C., Zhang, Z., Qiu, F. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. (2005) [Pubmed]
  3. Essential control of an endothelial cell ISOC by the spectrin membrane skeleton. Wu, S., Sangerman, J., Li, M., Brough, G.H., Goodman, S.R., Stevens, T. J. Cell Biol. (2001) [Pubmed]
  4. Store-operated Ca2+ current and TRPV6 channels in lymph node prostate cancer cells. Bödding, M., Fecher-Trost, C., Flockerzi, V. J. Biol. Chem. (2003) [Pubmed]
  5. Ca2+-dependent inactivation of a store-operated Ca2+ current in human submandibular gland cells. Role of a staurosporine-sensitive protein kinase and the intracellular Ca2+ pump. Liu, X., O'Connell, A., Ambudkar, I.S. J. Biol. Chem. (1998) [Pubmed]
  6. Evaluating the occupational physical fitness of Canadian forces infantry personnel. Jetté, M., Kimick, A., Sidney, K. Military medicine. (1989) [Pubmed]
  7. Evaluation of an indoor standardized obstacle course for Canadian infantry personnel. Jetté, M., Kimick, A., Sidney, K. Canadian journal of sport sciences = Journal canadien des sciences du sport. (1990) [Pubmed]
  8. A multilocus system for studying tissue and subcellular specialization. The pH and temperature dependence of the two major NADP-dependent isocitrate dehydrogenase isozymes of the fish Fundulus heteroclitus. Gonzalez-Villaseñor, L.I., Powers, D.A. J. Biol. Chem. (1986) [Pubmed]
  9. Co-activation of nonselective cation channels by store depletion and oxidative stress in monocytic U937 cells. Li, H.F., Shen, A.Y., Jan, C.R., Wu, S.N. The Chinese journal of physiology. (1998) [Pubmed]
  10. Evidence against reciprocal regulation of Ca2+ entry by vasopressin in A7r5 rat aortic smooth-muscle cells. Brueggemann, L.I., Markun, D.R., Barakat, J.A., Chen, H., Byron, K.L. Biochem. J. (2005) [Pubmed]
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