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Gene Review

GULP1  -  GULP, engulfment adaptor PTB domain...

Homo sapiens

Synonyms: CED-6, CED6, Cell death protein 6 homolog, GULP, PTB domain adapter protein CED-6, ...
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High impact information on GULP1


Biological context of GULP1


Anatomical context of GULP1

  • The 34 kDa hCED-6 protein is expressed in most tissues, some human cancer cells, and in primary human macrophages [3].

Analytical, diagnostic and therapeutic context of GULP1


  1. Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules. Ranganathan, S., Liu, C.X., Migliorini, M.M., Von Arnim, C.A., Peltan, I.D., Mikhailenko, I., Hyman, B.T., Strickland, D.K. J. Biol. Chem. (2004) [Pubmed]
  2. Identification and characterization of a dimerization domain in CED-6, an adapter protein involved in engulfment of apoptotic cells. Su, H.P., Brugnera, E., Van Criekinge, W., Smits, E., Hengartner, M., Bogaert, T., Ravichandran, K.S. J. Biol. Chem. (2000) [Pubmed]
  3. The human homologue of Caenorhabditis elegans CED-6 specifically promotes phagocytosis of apoptotic cells. Smits, E., Van Criekinge, W., Plaetinck, G., Bogaert, T. Curr. Biol. (1999) [Pubmed]
  4. Human CED-6 encodes a functional homologue of the Caenorhabditis elegans engulfment protein CED-6. Liu, Q.A., Hengartner, M.O. Curr. Biol. (1999) [Pubmed]
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