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Gene Review:

HSD17B7 - hydroxysteroid (17-beta) dehydrogenase 7

Homo sapiens

Synonyms: 17-beta-HSD 7, 17-beta-hydroxysteroid dehydrogenase 7, 3-keto-steroid reductase, Estradiol 17-beta-dehydrogenase 7, PRAP, ...

Marijanovic, Z. et al., Peltoketo, H. et al., Ohnesorg, T. et al., Wang, X.S. et al., Ohnesorg, T. et al., et al.

Peltoketo, Nokelainen, Piao, Vihko, Vihko,

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Disease relevance of HSD17B7

In addition, PRAP facilitates the evaluation of models for prostate cancer risk counseling and screening in the community [1].

High impact information on HSD17B7

We conclude that HSD17B7 participates in postsqualene cholesterol biosynthesis, thus completing the molecular cloning of all genes of this central metabolic pathway [2].
The protein encoded by the HSD17B7 gene was originally described as a prolactin receptor-associated protein and as 17beta-hydroxysteroid dehydrogenase (HSD) type 7 [2].
A fusion of HSD17B7 with green fluorescent protein is located in the endoplasmic reticulum, the site of postsqualene cholesterogenesis [2].
The participation of these sites in transcriptional regulation of HSD17B7 was proven by electro-mobility shift assay and site-directed mutagenesis of the corresponding binding sites [3].
Analysis of the 5' flanking regions of human and murine HSD17B7: identification of a cholesterol dependent enhancer region [4].

Biological context of HSD17B7

To elucidate the mechanism governing HSD17B7 expression and its function, we analyzed the promoter regions by bioinformatic and experimental approaches [5].
In order to gain insight into the transcriptional regulation, and thereby into in vivo functionality of HSD17B7, we analyzed and compared the 5' flanking regions of the corresponding human and murine genes [4].

Anatomical context of HSD17B7

A moderate or slight signal for mouse 17HSD7/PRAP mRNA has also been demonstrated in samples of placenta and mammary gland, for example [6].
Western blots analysis was performed using antibodies against the pro-caspase-3, or PRAP (Poly (ADP-ribose) polymerase).The results showed that delta-elemene exhibited a marked antiproliferative effect on Hela cells in dose- and time-dependent manners, and had little inhibition to normal human liver cell line WRL-68 [7].

Associations of HSD17B7 with chemical compounds

The expression of 17HSD7, which has also been described as a prolactin receptor-associated protein (PRAP), is particularly up-regulated in corpus luteum during the second half of rodent pregnancy [6].

References

Prostate cancer risk assessment program. A model for the early detection of prostate cancer. Bruner, D.W., Baffoe-Bonnie, A., Miller, S., Diefenbach, M., Tricoli, J.V., Daly, M., Pinover, W., Grumet, S.C., Stofey, J., Ross, E., Raysor, S., Balshem, A., Malick, J., Engstrom, P., Hanks, G.E., Mirchandani, I. Oncology (Williston Park, N.Y.) (1999) [Pubmed]
Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis. Marijanovic, Z., Laubner, D., Moller, G., Gege, C., Husen, B., Adamski, J., Breitling, R. Mol. Endocrinol. (2003) [Pubmed]
Transcriptional regulation of human and murine 17beta-hydroxysteroid dehydrogenase type-7 confers its participation in cholesterol biosynthesis. Ohnesorg, T., Keller, B., Hrabé de Angelis, M., Adamski, J. J. Mol. Endocrinol. (2006) [Pubmed]
Analysis of the 5' flanking regions of human and murine HSD17B7: identification of a cholesterol dependent enhancer region. Ohnesorg, T., Adamski, J. Mol. Cell. Endocrinol. (2006) [Pubmed]
Promoter analyses of human and mouse 17beta-hydroxysteroid dehydrogenase type 7. Ohnesorg, T., Adamski, J. J. Steroid Biochem. Mol. Biol. (2005) [Pubmed]
Two 17beta-hydroxysteroid dehydrogenases (17HSDs) of estradiol biosynthesis: 17HSD type 1 and type 7. Peltoketo, H., Nokelainen, P., Piao, Y.S., Vihko, R., Vihko, P. J. Steroid Biochem. Mol. Biol. (1999) [Pubmed]
The Effect of delta-Elemene on Hela Cell Lines by Apoptosis Induction. Wang, X.S., Yang, W., Tao, S.J., Li, K., Li, M., Dong, J.H., Wang, M.W. Yakugaku Zasshi (2006) [Pubmed]

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HSD17B7	Bos taurus
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hsd17b7	Danio rerio
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KLLA0F19756g	Kluyveromyces lactis NRRL Y-1140
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ERG27	Saccharomyces cerevisiae S288c
erg27	Schizosaccharomyces pombe 972h-
hsd17b7	Xenopus (Silurana) tropicalis

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