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ERG27  -  3-keto-steroid reductase

Saccharomyces cerevisiae S288c

Synonyms: YLR100W
 
 
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High impact information on ERG27

 

Biological context of ERG27

  • Restoration of Erg7p enzyme activity and LPs localization was achieved in an erg27 strain transformed with a plasmid containing a wild-type ERG27 allele [4].
 

Anatomical context of ERG27

 

Associations of ERG27 with chemical compounds

  • C. albicans erg6 and erg24 mutants were also employed along with the inhibitors, itraconazole and zaragozic acid A, to characterize ERG27 expression using Northern analysis [5].
  • Two-hybrid analysis indicated that Erg25p, Erg26p, and Erg27p, which are required for the biosynthesis of zymosterol, form a complex within the cell [6].
  • 17beta-HSD7 shows significant homology to a yeast 3-ketosteroid reductase (ERG27) involved in ergosterol biosynthesis [7].
  • Its recent cloning into a yeast mutant deficient in ERG27 led to its functional characterization as the 3-ketoreductase of the cholesterol biosynthesis pathway [8].
  • The C. albicans erg27 strain was able to grow only in the presence of maltose indicating that the ERG27 gene is essential [5].
 

Other interactions of ERG27

References

  1. Protein-protein interactions among C-4 demethylation enzymes involved in yeast sterol biosynthesis. Mo, C., Valachovic, M., Randall, S.K., Nickels, J.T., Bard, M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation. Gachotte, D., Sen, S.E., Eckstein, J., Barbuch, R., Krieger, M., Ray, B.D., Bard, M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  3. Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis. Marijanovic, Z., Laubner, D., Moller, G., Gege, C., Husen, B., Adamski, J., Breitling, R. Mol. Endocrinol. (2003) [Pubmed]
  4. In yeast sterol biosynthesis the 3-keto reductase protein (Erg27p) is required for oxidosqualene cyclase (Erg7p) activity. Mo, C., Milla, P., Athenstaedt, K., Ott, R., Balliano, G., Daum, G., Bard, M. Biochim. Biophys. Acta (2003) [Pubmed]
  5. Isolation, characterization, and regulation of the Candida albicans ERG27 gene encoding the sterol 3-keto reductase. Pierson, C.A., Jia, N., Mo, C., Lees, N.D., Sturm, A.M., Eckstein, J., Barbuct, R., Bard, M. Med. Mycol. (2004) [Pubmed]
  6. The effect of the erg26-1 mutation on the regulation of lipid metabolism in Saccharomyces cerevisiae. Baudry, K., Swain, E., Rahier, A., Germann, M., Batta, A., Rondet, S., Mandala, S., Henry, K., Tint, G.S., Edlind, T., Kurtz, M., Nickels, J.T. J. Biol. Chem. (2001) [Pubmed]
  7. 17beta-hydroxysteroid dehydrogenase type 7--an ancient 3-ketosteroid reductase of cholesterogenesis. Breitling, R., Krazeisen, A., Möller, G., Adamski, J. Mol. Cell. Endocrinol. (2001) [Pubmed]
  8. 17Beta-hydroxysteroid dehydrogenase type 7 (Hsd17b7) reverts cholesterol auxotrophy in NS0 cells. Seth, G., McIvor, R.S., Hu, W.S. J. Biotechnol. (2006) [Pubmed]
 
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