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Gene Review

S100B  -  S100 calcium binding protein B

Bos taurus

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Disease relevance of LOC525716


High impact information on LOC525716

  • The glial-derived calcium-binding protein S100B can be secreted to act as a neurotrophic factor or a mitogen, stimulating proliferation of glial cells [2].
  • Thus, this S100A1-S100B protein-mediated calcium-modulated signal transduction mechanism is novel [3].
  • Conformational changes in the beta-subunit of the bovine brain Ca2+-binding protein S100b (S100-beta) accompanying Ca2+ binding were investigated by analysis of the spectroscopic properties of the single tyrosine residue (Tyr17 beta) and flow-dialysis binding experiments [4].
  • Modulation of glial activation by astrocyte-derived protein S100B: differential responses of astrocyte and microglial cultures [5].
  • The astrocyte-derived protein S100B stimulates production of inducible nitric oxide synthase and nitric oxide (NO) in astrocytes [Hu et al., 1996, J. Biol. Chem. 271:2543], but its effect on microglia is not known [5].

Biological context of LOC525716

  • S100B (S100beta) is a member of the S100 family of small calcium-binding proteins: members of this family contain two helix-loop-helix calcium-binding motifs and interact with a wide range of proteins involved mainly in the cytoskeleton and cell proliferation [1].

Anatomical context of LOC525716


Analytical, diagnostic and therapeutic context of LOC525716


  1. The solution structure of the bovine S100B protein dimer in the calcium-free state. Kilby, P.M., Van Eldik, L.J., Roberts, G.C. Structure (1996) [Pubmed]
  2. Cysteine oxidation in the mitogenic S100B protein leads to changes in phosphorylation by catalytic CKII-alpha subunit. Scotto, C., Mély, Y., Ohshima, H., Garin, J., Cochet, C., Chambaz, E., Baudier, J. J. Biol. Chem. (1998) [Pubmed]
  3. Molecular characterization of S100A1-S100B protein in retina and its activation mechanism of bovine photoreceptor guanylate cyclase. Duda, T., Goraczniak, R.M., Sharma, R.K. Biochemistry (1996) [Pubmed]
  4. The Ca2+-binding sequence in bovine brain S100b protein beta-subunit. A spectroscopic study. Baudier, J., Cole, R.D. Biochem. J. (1989) [Pubmed]
  5. Modulation of glial activation by astrocyte-derived protein S100B: differential responses of astrocyte and microglial cultures. Petrova, T.V., Hu, J., Van Eldik, L.J. Brain Res. (2000) [Pubmed]
  6. Prognostic value of serum analyses of S-100 beta protein in malignant melanoma. von Schoultz, E., Hansson, L.O., Djureen, E., Hansson, J., Kärnell, R., Nilsson, B., Stigbrand, T., Ringborg, U. Melanoma Res. (1996) [Pubmed]
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