Disease relevance of LOC525716

• S100B is a neurite-extension factor and levels of S100B are elevated in the brains of patients with Alzheimer's disease or Down's syndrome: the pattern of S100B overexpression in Alzheimer's disease correlates with the pattern of neuritic-plaque formation [1].

High impact information on LOC525716

• The glial-derived calcium-binding protein S100B can be secreted to act as a neurotrophic factor or a mitogen, stimulating proliferation of glial cells [2].
• Thus, this S100A1-S100B protein-mediated calcium-modulated signal transduction mechanism is novel [3].
• Conformational changes in the beta-subunit of the bovine brain Ca2+-binding protein S100b (S100-beta) accompanying Ca2+ binding were investigated by analysis of the spectroscopic properties of the single tyrosine residue (Tyr17 beta) and flow-dialysis binding experiments [4].
• Modulation of glial activation by astrocyte-derived protein S100B: differential responses of astrocyte and microglial cultures [5].
• The astrocyte-derived protein S100B stimulates production of inducible nitric oxide synthase and nitric oxide (NO) in astrocytes [Hu et al., 1996, J. Biol. Chem. 271:2543], but its effect on microglia is not known [5].

Biological context of LOC525716

• S100B (S100beta) is a member of the S100 family of small calcium-binding proteins: members of this family contain two helix-loop-helix calcium-binding motifs and interact with a wide range of proteins involved mainly in the cytoskeleton and cell proliferation [1].

Anatomical context of LOC525716

• Molecular characterization of S100A1-S100B protein in retina and its activation mechanism of bovine photoreceptor guanylate cyclase [3].

Analytical, diagnostic and therapeutic context of LOC525716

• An immunoradiometric assay with three monoclonal antibodies against bovine S-100 protein beta subunit was used [6].

References