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Gene Review

S100b  -  S100 calcium binding protein B

Rattus norvegicus

Synonyms: Protein S100-B, S-100 protein beta chain, S-100 protein subunit beta, S100 calcium-binding protein B
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Disease relevance of S100b


Psychiatry related information on S100b


High impact information on S100b


Chemical compound and disease context of S100b


Biological context of S100b

  • Idiotypic antibodies against protein S100b inhibited synaptic transmission from Schaffer collateral axons to pyramidal neurons, but had no effect on neuronal responses to antidromic stimulation [9].
  • Idiotypic antibodies against protein S100b suppressed changes in neuronal responses to orthodromic stimulation during long-term potentiation, while antiidiotypic antibodies facilitated these effects [9].
  • Noncovalent interaction between tau and S100b depended on the presence of Ca2+ or Zn2+ and resulted in total inhibition of tau phosphorylation by protein kinase II [5].
  • The IC50 of S100b for beta I and beta II PKC was 8 microM while for alpha and gamma PKC it was 64 microM [10].
  • We studied the effects of S100b protein in doses stimulating (500 and 50 ng) or inhibiting (5 ng) apoptosis in nerve cells on acquisition, retention, and retrieval of extinction of the acoustic startle response and conditioned fear in adult rats [11].

Anatomical context of S100b

  • In the three prosencephalic areas, astrocytes' cell area (GFAP-ir cells) increased after EtOH exposure and tended to return to normality after abstinence, while cytoplasmic astroglial S100b protein-ir, relative area of MAP-2-ir and Nf-200-ir fibers decreased, and later partially recovered [12].
  • Effects of idiotypic and antiidiotypic antibodies against protein S100b on synaptic transmission and long-term potentiation of CA1 pyramidal neurons in rat hippocampus were studied [9].
  • The data suggest that endogenous S100b is involved in the regulation of microtubule assembly in brain extracts [13].
  • S100b contents in the hippocampus, hypothalamus, frontal cortex, and cerebellar hemispheres and vermis, and in the basal nuclei were measured in rat brains 0.5, 1, 2, 4, 6, 8, 24, and 48 h after long-term habituation to the startle response [14].
  • The astrocytic protein S100B stimulates neurite outgrowth and neuronal survival during CNS development [15].

Associations of S100b with chemical compounds

  • Although removal of extracellular Ca(+2) ions from the medium did not alter the basal lactate dehydrogenase leakage from cortical slices, an excessive increase in basal protein S100B release was seen under this condition [2].
  • In contrast, exogenous glutamate added into the medium protected the slices against reoxygenation induced increments in protein S100B and lactate dehydrogenase levels [2].
  • Purified rat S100b protein comigrates with bovine S100b protein in nondenaturant system electrophoresis but differs in its amino acid composition and in its electrophoretic mobility in urea-sodium dodecyl sulfate-polyacrylamide gel with bovine S100b protein [8].
  • Ipsapirone (10(-9)M) was more effective on neuronal cell bodies staining and S100b (10 ng/ml) was more effective in increasing the number of synaptophysin-IR varicosities on neuronal processes [16].
  • This effect in the whole animal may be due to activation of 5-HT1A receptors and a corresponding increases in S100b and corticosterone [16].

Other interactions of S100b


Analytical, diagnostic and therapeutic context of S100b


  1. Reduction in S100 protein beta subunit mRNA in C6 rat glioma cells following treatment with anti-microtubular drugs. Dunn, R., Landry, C., O'Hanlon, D., Dunn, J., Allore, R., Brown, I., Marks, A. J. Biol. Chem. (1987) [Pubmed]
  2. Protein S100B release from rat brain slices during and after ischemia: comparison with lactate dehydrogenase leakage. Büyükuysal, R.L. Neurochem. Int. (2005) [Pubmed]
  3. Induction of S100b in myocardium: an intrinsic inhibitor of cardiac hypertrophy. Parker, T.G., Marks, A., Tsoporis, J.N. Canadian journal of applied physiology = Revue canadienne de physiologie appliquée. (1998) [Pubmed]
  4. Long lasting sex-specific effects upon behavior and S100b levels after maternal separation and exposure to a model of post-traumatic stress disorder in rats. Diehl, L.A., Silveira, P.P., Leite, M.C., Crema, L.M., Portella, A.K., Billodre, M.N., Nunes, E., Henriques, T.P., Fidelix-da-Silva, L.B., Heis, M.D., Gonçalves, C.A., Quillfeldt, J.A., Dalmaz, C. Brain Res. (2007) [Pubmed]
  5. Interactions between the microtubule-associated tau proteins and S100b regulate tau phosphorylation by the Ca2+/calmodulin-dependent protein kinase II. Baudier, J., Cole, R.D. J. Biol. Chem. (1988) [Pubmed]
  6. Clonal sublines of rat neurotumor RT4 and cell differentiation. V. Comparison of Na+ influx, Rb+ efflux, and action potential among stem-cell, neuronal, and glial cell types. Tomozawa, Y., Sueoka, N., Miyake, M. Dev. Biol. (1985) [Pubmed]
  7. Location of the Zn(2+)-binding site on S100B as determined by NMR spectroscopy and site-directed mutagenesis. Wilder, P.T., Baldisseri, D.M., Udan, R., Vallely, K.M., Weber, D.J. Biochemistry (2003) [Pubmed]
  8. Rat brain S100b protein: purification, characterization, and ion binding properties. A comparison with bovine S100b protein. Baudier, J., Labourdette, G., Gerard, D. J. Neurochem. (1985) [Pubmed]
  9. Effects of antibodies against protein S100b on synaptic transmission and long-term potentiation in CA-1 hippocampal neurons in rats. Motin, V.G., Nikitin, V.P., Sherstnev, V.V. Bull. Exp. Biol. Med. (2002) [Pubmed]
  10. Glial-derived S100b protein selectively inhibits recombinant beta protein kinase C (PKC) phosphorylation of neuron-specific protein F1/GAP43. Sheu, F.S., Azmitia, E.C., Marshak, D.R., Parker, P.J., Routtenberg, A. Brain Res. Mol. Brain Res. (1994) [Pubmed]
  11. S100B protein in pro- and antiapoptotic doses produces different effects on defensive behavior in adult rats. Sherstnev, V.V., Storozheva, Z.I., Proshin, A.T., Makhmutov, R.Y., Puzyrev, A.V. Bull. Exp. Biol. Med. (2003) [Pubmed]
  12. A low chronic ethanol exposure induces morphological changes in the adolescent rat brain that are not fully recovered even after a long abstinence: an immunohistochemical study. Evrard, S.G., Duhalde-Vega, M., Tagliaferro, P., Mirochnic, S., Caltana, L.R., Brusco, A. Exp. Neurol. (2006) [Pubmed]
  13. Evidence that S100 proteins regulate microtubule assembly and stability in rat brain extracts. Hesketh, J., Baudier, J. Int. J. Biochem. (1986) [Pubmed]
  14. Heterochronous involvement of neurotrophic factors in the neurochemical organization of learning and memory processes in adult organisms. Sherstnev, V.V., Gruden', M.A., Storozheva, Z.I., Proshin, A.T. Neurosci. Behav. Physiol. (2003) [Pubmed]
  15. S100B proteins that lack one or both cysteine residues can induce inflammatory responses in astrocytes and microglia. Koppal, T., Lam, A.G., Guo, L., Van Eldik, L.J. Neurochem. Int. (2001) [Pubmed]
  16. Enhanced synaptophysin immunoreactivity in rat hippocampal culture by 5-HT 1A agonist, S100b, and corticosteroid receptor agonists. Nishi, M., Whitaker-Azmitia, P.M., Azmitia, E.C. Synapse (1996) [Pubmed]
  17. Acute and chronic electroconvulsive shock in rats: effects on peripheral markers of neuronal injury and glial activity. Busnello, J.V., Leke, R., Oses, J.P., Feier, G., Bruch, R., Quevedo, J., Kapczinski, F., Souza, D.O., Cruz Portela, L.V. Life Sci. (2006) [Pubmed]
  18. S100B, a neurotropic protein that modulates neuronal protein phosphorylation, is upregulated during lesion-induced collateral sprouting and reactive synaptogenesis. McAdory, B.S., Van Eldik, L.J., Norden, J.J. Brain Res. (1998) [Pubmed]
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