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MeSH Review

Senile Plaques

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Disease relevance of Senile Plaques


Psychiatry related information on Senile Plaques


High impact information on Senile Plaques


Chemical compound and disease context of Senile Plaques


Biological context of Senile Plaques


Anatomical context of Senile Plaques


Associations of Senile Plaques with chemical compounds

  • The stability of proteins that constitute the neurofibrillary tangles and senile plaques of Alzheimer disease suggests that they would be ideal substrates for nonenzymatic glycation, a process that occurs over long times, even at normal levels of glucose, ultimately resulting in the formation of advanced glycation end products (AGEs) [29].
  • There was a positive correlation (r = 0.914) between kainate binding and senile plaque number in deep cortical layers [30].
  • The resulting 39-43 amino acid beta-amyloid may be neurotoxic and disrupt neuronal connectivity after its accumulation in senile plaques [31].
  • We conclude that collagen XVIII is a novel heparan sulfate proteoglycan associated with vascular A beta and classic senile plaques and that at least the long form of collagen XVIII accumulates in amyloid-laden vessels and classic senile plaques [16].
  • Of the 20 samples from Nairobi, 3 (15%) brains exhibited neocortical A beta deposits that varied from numerous diffuse to highly localized compact or neuritic plaques, many of which were also thioflavin S positive [32].

Gene context of Senile Plaques


Analytical, diagnostic and therapeutic context of Senile Plaques


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  2. Amyloid beta-protein deposition in the leptomeninges and cerebral cortex. Shinkai, Y., Yoshimura, M., Morishima-Kawashima, M., Ito, Y., Shimada, H., Yanagisawa, K., Ihara, Y. Ann. Neurol. (1997) [Pubmed]
  3. Amyloid angiopathy in a Volga German family with Alzheimer's disease and a presenilin-2 mutation (N141I). Nochlin, D., Bird, T.D., Nemens, E.J., Ball, M.J., Sumi, S.M. Ann. Neurol. (1998) [Pubmed]
  4. Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease. Ferrer, I., Boada Rovira, M., Sánchez Guerra, M.L., Rey, M.J., Costa-Jussá, F. Brain Pathol. (2004) [Pubmed]
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  9. Mutant prion proteins in Gerstmann-Sträussler-Scheinker disease with neurofibrillary tangles. Hsiao, K., Dlouhy, S.R., Farlow, M.R., Cass, C., Da Costa, M., Conneally, P.M., Hodes, M.E., Ghetti, B., Prusiner, S.B. Nat. Genet. (1992) [Pubmed]
  10. A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor. Lu, D.C., Rabizadeh, S., Chandra, S., Shayya, R.F., Ellerby, L.M., Ye, X., Salvesen, G.S., Koo, E.H., Bredesen, D.E. Nat. Med. (2000) [Pubmed]
  11. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T.D., Hardy, J., Hutton, M., Kukull, W., Larson, E., Levy-Lahad, E., Viitanen, M., Peskind, E., Poorkaj, P., Schellenberg, G., Tanzi, R., Wasco, W., Lannfelt, L., Selkoe, D., Younkin, S. Nat. Med. (1996) [Pubmed]
  12. Decreased alpha-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's disease. Lannfelt, L., Basun, H., Wahlund, L.O., Rowe, B.A., Wagner, S.L. Nat. Med. (1995) [Pubmed]
  13. Tau protein directly interacts with the amyloid beta-protein precursor: implications for Alzheimer's disease. Smith, M.A., Siedlak, S.L., Richey, P.L., Mulvihill, P., Ghiso, J., Frangione, B., Tagliavini, F., Giaccone, G., Bugiani, O., Praprotnik, D. Nat. Med. (1995) [Pubmed]
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  15. Neuroprotective strategy for Alzheimer disease: intranasal administration of a fatty neuropeptide. Gozes, I., Bardea, A., Reshef, A., Zamostiano, R., Zhukovsky, S., Rubinraut, S., Fridkin, M., Brenneman, D.E. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  16. Collagen XVIII: a novel heparan sulfate proteoglycan associated with vascular amyloid depositions and senile plaques in Alzheimer's disease brains. van Horssen, J., Wilhelmus, M.M., Heljasvaara, R., Pihlajaniemi, T., Wesseling, P., de Waal, R.M., Verbeek, M.M. Brain Pathol. (2002) [Pubmed]
  17. Correlation of cortical cholinergic and GABA deficits with quantitative neuropathological findings in senile dementia. Mountjoy, C.Q., Rossor, M.N., Iversen, L.L., Roth, M. Brain (1984) [Pubmed]
  18. Comparison of PET, MRI, and CT with pathology in a proven case of Alzheimer's disease. McGeer, P.L., Kamo, H., Harrop, R., McGeer, E.G., Martin, W.R., Pate, B.D., Li, D.K. Neurology (1986) [Pubmed]
  19. Altered phosphorylation of growth-associated protein B50/GAP-43 in Alzheimer disease with high neurofibrillary tangle density. Martzen, M.R., Nagy, A., Coleman, P.D., Zwiers, H. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  20. Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion. Haass, C., Hung, A.Y., Selkoe, D.J. J. Neurosci. (1991) [Pubmed]
  21. Alzheimer vaccine: amyloid-beta on trial. Robinson, S.R., Bishop, G.M., Münch, G. Bioessays (2003) [Pubmed]
  22. BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper. Angeletti, B., Waldron, K.J., Freeman, K.B., Bawagan, H., Hussain, I., Miller, C.C., Lau, K.F., Tennant, M.E., Dennison, C., Robinson, N.J., Dingwall, C. J. Biol. Chem. (2005) [Pubmed]
  23. Strategies to alter the progression of Alzheimer's disease. Siman, R., Scott, R.W. Curr. Opin. Biotechnol. (1996) [Pubmed]
  24. Evidence for cholinergic neurites in senile plaques. Kitt, C.A., Price, D.L., Struble, R.G., Cork, L.C., Wainer, B.H., Becher, M.W., Mobley, W.C. Science (1984) [Pubmed]
  25. Cholinergic markers in elderly patients with early signs of Alzheimer disease. Davis, K.L., Mohs, R.C., Marin, D., Purohit, D.P., Perl, D.P., Lantz, M., Austin, G., Haroutunian, V. JAMA (1999) [Pubmed]
  26. Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro. Kirschner, D.A., Inouye, H., Duffy, L.K., Sinclair, A., Lind, M., Selkoe, D.J. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  27. Distribution of precursor amyloid-beta-protein messenger RNA in human cerebral cortex: relationship to neurofibrillary tangles and neuritic plaques. Lewis, D.A., Higgins, G.A., Young, W.G., Goldgaber, D., Gajdusek, D.C., Wilson, M.C., Morrison, J.H. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  28. Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain. Cataldo, A.M., Nixon, R.A. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  29. Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress. Yan, S.D., Chen, X., Schmidt, A.M., Brett, J., Godman, G., Zou, Y.S., Scott, C.W., Caputo, C., Frappier, T., Smith, M.A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  30. Differential alterations of cortical glutamatergic binding sites in senile dementia of the Alzheimer type. Chalmers, D.T., Dewar, D., Graham, D.I., Brooks, D.N., McCulloch, J. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  31. The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling. Rossner, S., Ueberham, U., Schliebs, R., Perez-Polo, J.R., Bigl, V. Prog. Neurobiol. (1998) [Pubmed]
  32. Cerebral amyloid beta protein deposits and other Alzheimer lesions in non-demented elderly east Africans. Ogeng'o, J.A., Cohen, D.L., Sayi, J.G., Matuja, W.B., Chande, H.M., Kitinya, J.N., Kimani, J.K., Friedland, R.P., Mori, H., Kalaria, R.N. Brain Pathol. (1996) [Pubmed]
  33. Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor. Van Nostrand, W.E., Wagner, S.L., Suzuki, M., Choi, B.H., Farrow, J.S., Geddes, J.W., Cotman, C.W., Cunningham, D.D. Nature (1989) [Pubmed]
  34. Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Rebeck, G.W., Reiter, J.S., Strickland, D.K., Hyman, B.T. Neuron (1993) [Pubmed]
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  36. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Jankowsky, J.L., Fadale, D.J., Anderson, J., Xu, G.M., Gonzales, V., Jenkins, N.A., Copeland, N.G., Lee, M.K., Younkin, L.H., Wagner, S.L., Younkin, S.G., Borchelt, D.R. Hum. Mol. Genet. (2004) [Pubmed]
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  39. Localization of superoxide dismutases in Alzheimer's disease and Down's syndrome neocortex and hippocampus. Furuta, A., Price, D.L., Pardo, C.A., Troncoso, J.C., Xu, Z.S., Taniguchi, N., Martin, L.J. Am. J. Pathol. (1995) [Pubmed]
  40. Lovastatin enhances Abeta production and senile plaque deposition in female Tg2576 mice. Park, I.H., Hwang, E.M., Hong, H.S., Boo, J.H., Oh, S.S., Lee, J., Jung, M.W., Bang, O.Y., Kim, S.U., Mook-Jung, I. Neurobiol. Aging (2003) [Pubmed]
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