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Gene Review

S100b  -  S100 protein, beta polypeptide, neural

Mus musculus

Synonyms: AI850290, Bpb, Protein S100-B, S-100 protein beta chain, S-100 protein subunit beta, ...
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Disease relevance of S100b


High impact information on S100b

  • Here, we demonstrate that calcium-binding protein S100B, which is synthesized in considerable amounts in astrocytes (a major glial cell subtype), modulates long-term synaptic plasticity [4].
  • Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein [5].
  • Divergent pathways of gene expression are activated by the RAGE ligands S100b and AGE-BSA [6].
  • RESULTS: Treatment of human pancreatic islets with HG and S100b led to a three-five-fold induction of PTGS2 mRNA (p<0.001) [7].
  • We previously showed that, in contrast to the distribution of S100b (beta beta), S100a0 (alpha alpha) is mainly present in human skeletal and heart muscles at the level of 1-2 micrograms/mg of soluble protein and is universally distributed at high levels in skeletal and heart muscles of various mammals [8].

Biological context of S100b

  • The mouse Mif gene maps to the middle region of chromosome 10, between Bcr and S100b, which have been mapped to human chromosomes 22q11 and 21q22.3, respectively [9].
  • Cells expressing the pan-neuronal markers, neurofilament-M and Hu, or the glial marker, S100b, were observed undergoing mitosis [10].

Anatomical context of S100b


Associations of S100b with chemical compounds

  • Moreover, addition of citrate, a potent ligand for trivalent cations, resulted in a significant withdrawal in mAb recognition of aluminium which was previously bound to either CaM or S100b proteins [12].

Other interactions of S100b

  • These results suggest that a predominant form of S100 protein in human myocardial cells is not S100a (alpha beta) or S100b (beta beta), but S100a0 (alpha alpha) [13].


  1. Astrocytosis and axonal proliferation in the hippocampus of S100b transgenic mice. Reeves, R.H., Yao, J., Crowley, M.R., Buck, S., Zhang, X., Yarowsky, P., Gearhart, J.D., Hilt, D.C. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  2. Acquisition of neuronal and glial markers by neural crest-derived cells in the mouse intestine. Young, H.M., Bergner, A.J., Müller, T. J. Comp. Neurol. (2003) [Pubmed]
  3. A new specific method for measuring S-100B in serum. Stigbrand, T., Nyberg, L., Ullén, A., Haglid, K., Sandström, E., Brundell, J. Int. J. Biol. Markers (2000) [Pubmed]
  4. Glial protein S100B modulates long-term neuronal synaptic plasticity. Nishiyama, H., Knopfel, T., Endo, S., Itohara, S. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  5. Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein. Baudier, J., Delphin, C., Grunwald, D., Khochbin, S., Lawrence, J.J. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  6. Divergent pathways of gene expression are activated by the RAGE ligands S100b and AGE-BSA. Valencia, J.V., Mone, M., Zhang, J., Weetall, M., Buxton, F.P., Hughes, T.E. Diabetes (2004) [Pubmed]
  7. Increased expression of cyclooxygenase-2 in human pancreatic islets treated with high glucose or ligands of the advanced glycation endproduct-specific receptor (AGER), and in islets from diabetic mice. Shanmugam, N., Todorov, I.T., Nair, I., Omori, K., Reddy, M.A., Natarajan, R. Diabetologia (2006) [Pubmed]
  8. S100a0 (alpha alpha) protein, a calcium-binding protein, is localized in the slow-twitch muscle fiber. Haimoto, H., Kato, K. J. Neurochem. (1987) [Pubmed]
  9. Structural characterization and chromosomal location of the mouse macrophage migration inhibitory factor gene and pseudogenes. Bozza, M., Kolakowski, L.F., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., David, J.R., Gerard, C. Genomics (1995) [Pubmed]
  10. The location and phenotype of proliferating neural-crest-derived cells in the developing mouse gut. Young, H.M., Turner, K.N., Bergner, A.J. Cell Tissue Res. (2005) [Pubmed]
  11. Separation of extremely acidic proteins, S-100 proteins and calmodulin, in some bovine tissues and mammalian brains by two-dimensional electrophoresis in the absence of denaturing agents. Manabe, T., Jitzukawa, S., Ishioka, N., Isobe, T., Okuyama, T. J. Biochem. (1982) [Pubmed]
  12. Specificity of an anti-aluminium monoclonal antibody toward free and protein-bound aluminium. Levy, R., Shohat, L., Solomon, B. J. Inorg. Biochem. (1998) [Pubmed]
  13. S100a0 (alpha alpha) protein in cardiac muscle. Isolation from human cardiac muscle and ultrastructural localization. Haimoto, H., Kato, K. Eur. J. Biochem. (1988) [Pubmed]
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