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Gene Review

raps  -  rapsynoid

Drosophila melanogaster

Synonyms: CG5692, Dmel\CG5692, PINS, Pins, Rad, ...
 
 
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High impact information on raps

  • Microtubule-induced Pins/Galphai cortical polarity in Drosophila neuroblasts [1].
  • Finally, Baz and the Dlg/Pins complex are required for the asymmetric localization of Numb [2].
  • Dlg interacts directly with Pins and regulates the localization of Pins and Baz [2].
  • Locomotion defects, together with Pins, regulates heterotrimeric G-protein signaling during Drosophila neuroblast asymmetric divisions [3].
  • Moreover, Mud localizes to centrosomes during mitosis independently of Pins to regulate centrosomal organization [4].
 

Biological context of raps

 

Anatomical context of raps

  • Mud directly associates and colocalizes with Pins at the cell cortex overlying the spindle pole(s) in both neuroblasts and epithelial cells [4].
  • Drosophila Pins-binding protein Mud regulates spindle-polarity coupling and centrosome organization [4].
 

Physical interactions of raps

  • The predicted sequence of Pins contained tetratrico-peptide repeats (TPRs) and motifs implicated in binding Galpha proteins [10].
 

Regulatory relationships of raps

  • The planar cell polarity protein Strabismus promotes Pins anterior localization during asymmetric division of sensory organ precursor cells in Drosophila [7].
 

Other interactions of raps

  • Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation [11].
  • Hence, the abilities of Pins to cortically localize, to apically localize, and to restore Insc apical localization are all separable, and all three capabilities are necessary to mediate asymmetric division [12].
  • We show that the C-terminal region containing the G alpha i binding GoLoco motifs is necessary and sufficient for targeting to the neuroblast cortex, which appears to be a prerequisite for apical localization of Pins [12].
  • We propose that the Stbm-dependent recruitment of Pins at the anterior cortex of the pI cell is a novel read-out of planar cell polarity [7].
 

Analytical, diagnostic and therapeutic context of raps

References

  1. Microtubule-induced Pins/Galphai cortical polarity in Drosophila neuroblasts. Siegrist, S.E., Doe, C.Q. Cell (2005) [Pubmed]
  2. The Partner of Inscuteable/Discs-large complex is required to establish planar polarity during asymmetric cell division in Drosophila. Bellaïche, Y., Radovic, A., Woods, D.F., Hough, C.D., Parmentier, M.L., O'Kane, C.J., Bryant, P.J., Schweisguth, F. Cell (2001) [Pubmed]
  3. Locomotion defects, together with Pins, regulates heterotrimeric G-protein signaling during Drosophila neuroblast asymmetric divisions. Yu, F., Wang, H., Qian, H., Kaushik, R., Bownes, M., Yang, X., Chia, W. Genes Dev. (2005) [Pubmed]
  4. Drosophila Pins-binding protein Mud regulates spindle-polarity coupling and centrosome organization. Izumi, Y., Ohta, N., Hisata, K., Raabe, T., Matsuzaki, F. Nat. Cell Biol. (2006) [Pubmed]
  5. Drosophila E-cadherin regulates the orientation of asymmetric cell division in the sensory organ lineage. Le Borgne, R., Bellaïche, Y., Schweisguth, F. Curr. Biol. (2002) [Pubmed]
  6. A mouse homologue of Drosophila pins can asymmetrically localize and substitute for pins function in Drosophila neuroblasts. Yu, F., Morin, X., Kaushik, R., Bahri, S., Yang, X., Chia, W. J. Cell. Sci. (2003) [Pubmed]
  7. The planar cell polarity protein Strabismus promotes Pins anterior localization during asymmetric division of sensory organ precursor cells in Drosophila. Bellaïche, Y., Beaudoin-Massiani, O., Stuttem, I., Schweisguth, F. Development (2004) [Pubmed]
  8. The Drosophila NuMA Homolog Mud regulates spindle orientation in asymmetric cell division. Bowman, S.K., Neumüller, R.A., Novatchkova, M., Du, Q., Knoblich, J.A. Dev. Cell (2006) [Pubmed]
  9. Rapsynoid/partner of inscuteable controls asymmetric division of larval neuroblasts in Drosophila. Parmentier, M.L., Woods, D., Greig, S., Phan, P.G., Radovic, A., Bryant, P., O'Kane, C.J. J. Neurosci. (2000) [Pubmed]
  10. A protein complex containing Inscuteable and the Galpha-binding protein Pins orients asymmetric cell divisions in Drosophila. Schaefer, M., Shevchenko, A., Shevchenko, A., Knoblich, J.A. Curr. Biol. (2000) [Pubmed]
  11. Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation. Lee, C.Y., Robinson, K.J., Doe, C.Q. Nature (2006) [Pubmed]
  12. Membrane targeting and asymmetric localization of Drosophila partner of inscuteable are discrete steps controlled by distinct regions of the protein. Yu, F., Ong, C.T., Chia, W., Yang, X. Mol. Cell. Biol. (2002) [Pubmed]
  13. Asymmetric localization of LGN but not AGS3, two homologs of Drosophila pins, in dividing human neural progenitor cells. Fuja, T.J., Schwartz, P.H., Darcy, D., Bryant, P.J. J. Neurosci. Res. (2004) [Pubmed]
 
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