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Gene Review

DLL4  -  delta-like 4 (Drosophila)

Homo sapiens

Synonyms: Delta-like protein 4, Delta4, Drosophila Delta homolog 4, UNQ1895/PRO4341
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Disease relevance of DLL4


Psychiatry related information on DLL4

  • No causative DLL4 mutations in periodic catatonia patients from 15q15 linked families [2].

High impact information on DLL4

  • In transgenic livers, we showed that DLL4, active Notch4, and ephrin B2 were gradually up-regulated within the hepatocarcinoma progression and expressed on tumor sinusoidal endothelial cells [3].
  • The Notch signaling pathway and the delta-like 4 ligand (DLL4) play key roles in embryonic vascular development [1].
  • Down-regulation of DLL4 expression with RNA interference led to decreased expression of HEY1 and EphrinB2, and the inhibition of endothelial cell proliferation, migration, and network formation, all of which are important processes in tumor angiogenesis [1].
  • EXPERIMENTAL DESIGN: The expression of DLL4, CD34, and VEGF were studied in a cohort of 60 bladder tumors and 10 normal samples using quantitative PCR [4].
  • Variants of NOTCH4 are associated with schizophrenia, thus DLL4 is both a functional as well as a positional candidate for schizophrenia [2].

Anatomical context of DLL4


Analytical, diagnostic and therapeutic context of DLL4

  • In situ hybridization was used to study the pattern of DLL4 expression in 22 tumor and 9 normal samples [4].
  • Magnetic microbeads were functionalized with the notch ligand DLL4 using streptavidin-biotin binding and antibody-antigen coupling [5].


  1. Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function. Patel, N.S., Li, J.L., Generali, D., Poulsom, R., Cranston, D.W., Harris, A.L. Cancer Res. (2005) [Pubmed]
  2. No causative DLL4 mutations in periodic catatonia patients from 15q15 linked families. McKeane, D.P., Meyer, J., Dobrin, S.E., Melmed, K.M., Ekawardhani, S., Tracy, N.A., Lesch, K.P., Stephan, D.A. Schizophr. Res. (2005) [Pubmed]
  3. The Role of the Vascular Endothelial Growth Factor-Delta-like 4 Ligand/Notch4-Ephrin B2 Cascade in Tumor Vessel Remodeling and Endothelial Cell Functions. Hainaud, P., Contrerès, J.O., Villemain, A., Liu, L.X., Plouët, J., Tobelem, G., Dupuy, E. Cancer Res. (2006) [Pubmed]
  4. Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer. Patel, N.S., Dobbie, M.S., Rochester, M., Steers, G., Poulsom, R., Le Monnier, K., Cranston, D.W., Li, J.L., Harris, A.L. Clin. Cancer Res. (2006) [Pubmed]
  5. Biomaterial-based notch signaling for the differentiation of hematopoietic stem cells into T cells. Taqvi, S., Dixit, L., Roy, K. Journal of biomedical materials research. Part A. (2006) [Pubmed]
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