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Gene Review

CRLS1  -  cardiolipin synthase 1

Homo sapiens

Synonyms: C20orf155, CLS, CLS1, Cardiolipin synthase, GCD10, ...
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High impact information on CRLS1

  • This cDNA exhibits sequence homology with members of a CLS gene family that share similar domain structure and chemical properties [1].
  • Furthermore, the hCLS1 gene was highly expressed in tissues such as heart, skeletal muscle, and liver, which have been shown to have high CLS activities [1].
  • Expression of the human CLS (hCLS1) cDNA in reticulocyte lysates or insect cells led to a marked increase in CLS activity [1].
  • Open reading frames located up- and downstream of the PKS displayed similarity with membrane synthesis-related proteins such as cardiolipin synthase [2].
  • Thyroid hormone and unsaturated fatty acids may regulate cardiolipin biosynthesis at the level of three key enzymes of the cytidine-5'-diphosphate-1,2-diacyl-sn-glycerol pathway, phosphatidylglycerol phosphate synthase, phosphatidyl-glycerolphosphate phosphatase and cardiolipin synthase [3].

Biological context of CRLS1

  • The MCM8 gene, consisting of 19 exons, is located contrapodal to a gene, consisting of 11 exons, encoding a homolog of the yeast GCD10 gene product [4].
  • A new member of the MCM protein family encoded by the human MCM8 gene, located contrapodal to GCD10 at chromosome band 20p12.3-13 [4].
  • Northern-blot analysis showed that the hCLS1 gene was predominantly expressed in tissues that require high levels of mitochondrial activities for energy metabolism, with the highest expression in skeletal and cardiac muscles [5].

Anatomical context of CRLS1

  • The recombinant hCLS1 enzyme expressed in COS-7 cells catalysed efficiently the synthesis of cardiolipin in vitro using CDP-DAG and PG as substrates [5].
  • Identification and functional characterization of hCLS1, a human cardiolipin synthase localized in mitochondria [5].
  • RESULTS: Of all solutions investigated, partially purified collagenase type 1 (T1C; Lot M0M4322, Code CLS-1, Worthington Biochemical Corporation, Lakewood, N.J., USA) at 37 degrees C was the most successful in grossly altering the consistency and appearance of adipose tissue [6].
  • Four isolated inner cell masses developed into putative ES cell lines, CLS1, CLS2, CLS3, CLS4, which have now been continuously cultured for eight months, corresponding to 30 passages [7].
  • High levels of hCLS1 expression were also detected in liver, pancreas, kidney and small intestine, implying a functional role of hCLS1 in these tissues [5].

Analytical, diagnostic and therapeutic context of CRLS1

  • SETTINGS AND PARTICIPANTS: Data were collected from 515 CLS/MT ITF participants who were part of an ongoing longitudinal study [8].


  1. Cloning and characterization of a cDNA encoding human cardiolipin synthase (hCLS1). Lu, B., Xu, F.Y., Jiang, Y.J., Choy, P.C., Hatch, G.M., Grunfeld, C., Feingold, K.R. J. Lipid Res. (2006) [Pubmed]
  2. Diversity of polyketide synthase genes from bacteria associated with the marine sponge Pseudoceratina clavata: culture-dependent and culture-independent approaches. Kim, T.K., Fuerst, J.A. Environ. Microbiol. (2006) [Pubmed]
  3. Regulation of cardiolipin biosynthesis in the heart. Hatch, G.M. Mol. Cell. Biochem. (1996) [Pubmed]
  4. A new member of the MCM protein family encoded by the human MCM8 gene, located contrapodal to GCD10 at chromosome band 20p12.3-13. Johnson, E.M., Kinoshita, Y., Daniel, D.C. Nucleic Acids Res. (2003) [Pubmed]
  5. Identification and functional characterization of hCLS1, a human cardiolipin synthase localized in mitochondria. Chen, D., Zhang, X.Y., Shi, Y. Biochem. J. (2006) [Pubmed]
  6. Discernment of adipose versus nervous tissue: a novel adjunct solution in lipomyelomeningocele surgery. Patwardhan, R.V., Tubbs, R.S., Leonard, R.J., Kelly, D., Killingsworth, C.R., Rollins, D.L., Smith, W.M., Ideker, R.E., Oakes, W.J. Pediatric neurosurgery. (2002) [Pubmed]
  7. Derivation and characterization of four new human embryonic stem cell lines: the Danish experience. Lysdahl, H., Gabrielsen, A., Minger, S.L., Patel, M.J., Fink, T., Petersen, K., Ebbesen, P., Zachar, V. Reprod. Biomed. Online (2006) [Pubmed]
  8. Learning and utilization of generic skills by practitioners in the field of clinical laboratory science/medical technology. Guiles, H.J., Ward-Cook, K. Clinical laboratory science : journal of the American Society for Medical Technology. (2006) [Pubmed]
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