Disease relevance of SLC6A20

• Finally, the mutants were tested for virulence in a murine model of cryptococcosis, and it was found that SIT1 was not required for virulence [1].

High impact information on SLC6A20

• A phylogenetically related transporter known as XT3 in human (SLC6A20) and XT3s1 in mouse was shown to function as an imino acid transporter, to localize also to kidney and small intestine and renamed SIT1 or Imino(B) [2].
• Among the 13 genes whose CGI were completely methylated in one or more cell lines, FOXA2 and XT3 were expressed in normal human mammary epithelial cells (HMEC) and were not expressed in cancer cell lines with complete methylation [3].
• This was subsequently confirmed by the identification of SLC6A20 as the long-sought IMINO system, a proline transporter found in kidney, intestine and brain [4].
• The iron- and cAMP-regulated gene SIT1 influences ferrioxamine B utilization, melanization and cell wall structure in Cryptococcus neoformans [1].
• However, two transporters, the proton amino acid transporter PAT1 (SLC36A1) and the IMINO transporter (SLC6A20) appear to play key roles in the resorption of glycine and proline [5].

Biological context of SLC6A20

• RESULTS: ANP increased ongoing from the sitting to the supine position (SIT-1: 13.2 +/- 4.7; SUP: 27.9 +/- 21.9 pg x ml(-1); p < 0.01) during protocol 1 and decreased after the onset of CPAP in seated subjects (SIT-2: 16.9 +/- 7.9; SIT-CPAP: 13.9 +/- 6.5 pg x ml(-1); p < 0.05) during protocol 2 [6].

Anatomical context of SLC6A20

• This review summarises evidence for expression of SLC36A1 and SLC6A20 in human small intestine, highlights the differences in functional characteristics of the imino acid carrier and IMINO transporter, and explains the confusion surrounding these two distinct transport systems [7].

Associations of SLC6A20 with chemical compounds

• However, it is the sodium/imino and amino acid cotransporter SLC6A20 which corresponds to the betaine carrier (identified in hamster, 1960s) and IMINO transporter (identified in rabbit and guinea pig, 1980s) [7].

References