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Gene Review

SLC6A20  -  solute carrier family 6 (proline IMINO...

Homo sapiens

Synonyms: SIT1, Sodium-and chloride-dependent transporter XTRP3, Sodium/imino-acid transporter 1, Solute carrier family 6 member 20, Transporter rB21A homolog, ...
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Disease relevance of SLC6A20


High impact information on SLC6A20


Biological context of SLC6A20

  • RESULTS: ANP increased ongoing from the sitting to the supine position (SIT-1: 13.2 +/- 4.7; SUP: 27.9 +/- 21.9 pg x ml(-1); p < 0.01) during protocol 1 and decreased after the onset of CPAP in seated subjects (SIT-2: 16.9 +/- 7.9; SIT-CPAP: 13.9 +/- 6.5 pg x ml(-1); p < 0.05) during protocol 2 [6].

Anatomical context of SLC6A20

  • This review summarises evidence for expression of SLC36A1 and SLC6A20 in human small intestine, highlights the differences in functional characteristics of the imino acid carrier and IMINO transporter, and explains the confusion surrounding these two distinct transport systems [7].

Associations of SLC6A20 with chemical compounds

  • However, it is the sodium/imino and amino acid cotransporter SLC6A20 which corresponds to the betaine carrier (identified in hamster, 1960s) and IMINO transporter (identified in rabbit and guinea pig, 1980s) [7].


  1. The iron- and cAMP-regulated gene SIT1 influences ferrioxamine B utilization, melanization and cell wall structure in Cryptococcus neoformans. Tangen, K.L., Jung, W.H., Sham, A.P., Lian, T., Kronstad, J.W. Microbiology (Reading, Engl.) (2007) [Pubmed]
  2. Luminal kidney and intestine SLC6 amino acid transporters of B0AT-cluster and their tissue distribution in Mus musculus. Romeo, E., Dave, M.H., Bacic, D., Ristic, Z., Camargo, S.M., Loffing, J., Wagner, C.A., Verrey, F. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
  3. Identification of 20 genes aberrantly methylated in human breast cancers. Miyamoto, K., Fukutomi, T., Akashi-Tanaka, S., Hasegawa, T., Asahara, T., Sugimura, T., Ushijima, T. Int. J. Cancer (2005) [Pubmed]
  4. The SLC6 orphans are forming a family of amino acid transporters. Bröer, S. Neurochem. Int. (2006) [Pubmed]
  5. The molecular basis of neutral aminoacidurias. Bröer, A., Cavanaugh, J.A., Rasko, J.E., Bröer, S. Pflugers Arch. (2006) [Pubmed]
  6. Effects of posture and positive airway pressure on plasma atrial natriuretic peptide and renal urodilatin excretion. Heringlake, M., Klaus, S., Bahlmann, L., Sehested, J., Pagel, H., Schmucker, P. Clin. Nephrol. (2001) [Pubmed]
  7. Deciphering the mechanisms of intestinal imino (and amino) acid transport: The redemption of SLC36A1. Thwaites, D.T., Anderson, C.M. Biochim. Biophys. Acta (2007) [Pubmed]
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