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Gene Review

Slc6a20b  -  solute carrier family 6 (neurotransmitter...

Mus musculus

Synonyms: AA986306, IMINO-K, Sit1, Slc6a20, Sodium-and chloride-dependent transporter XTRP3B, ...
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High impact information on Slc6a20

  • It also shows that the structurally highly similar orphan transporters XT2 and XT3 have the same luminal but a slightly differing axial localization along the kidney proximal tubule [1].
  • We show here by immunofluorescence that all four mouse B degrees AT-cluster transporters localize, with differential axial gradients, to the brush-border membrane of proximal kidney tubule and, with the possible exception of XT3, also of intestine [1].
  • Screening experiments to identify the substrate(s) of these proteins failed to identify specific uptake with any of the tested compounds; however, immunofluorescent microscopy demonstrated that epitope-tagged variants of the protein products of the XT2 and XT3 cDNAs were present on the plasma membrane of transfected cells [2].
  • Expression of the second gene (XT3) was found to be conserved in human kidney, and partial sequence was obtained from a human cDNA library [2].
  • The expressions of both XT2 and XT3 RNAs were determined in mouse and human tissues, respectively, and the locations of the two genes within the mouse genome were identified [2].

Anatomical context of Slc6a20


  1. Luminal kidney and intestine SLC6 amino acid transporters of B0AT-cluster and their tissue distribution in Mus musculus. Romeo, E., Dave, M.H., Bacic, D., Ristic, Z., Camargo, S.M., Loffing, J., Wagner, C.A., Verrey, F. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
  2. Cloning, gene structure and genomic localization of an orphan transporter from mouse kidney with six alternatively-spliced isoforms. Nash, S.R., Giros, B., Kingsmore, S.F., Kim, K.M., el-Mestikawy, S., Dong, Q., Fumagalli, F., Seldin, M.F., Caron, M.G. Recept. Channels (1998) [Pubmed]
  3. Molecular cloning of the mouse IMINO system: an Na+- and Cl--dependent proline transporter. Kowalczuk, S., Bröer, A., Munzinger, M., Tietze, N., Klingel, K., Bröer, S. Biochem. J. (2005) [Pubmed]
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