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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TMEM132A  -  transmembrane protein 132A

Homo sapiens

Synonyms: FLJ20539, GBP, HSPA5-binding protein 1, HSPA5BP1, KIAA1583, ...
 
 
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Disease relevance of TMEM132A

 

High impact information on TMEM132A

  • Because the sequence of GBP offered few clues to the possible function, we performed a GST-tagged GBP pull-down assay in PC12 lysates and identified GRP78, one of the heat shock proteins, as a counterpart [2].
  • Overexpression of GBP did not affect cell growth or morphological features but attenuated the time-dependent decrease in cell viability caused by serum deprivation compared with control cells [2].
  • After 48 h of serum starvation, Neuro2a cells overexpressing GBP were resistant to the cell death induced by serum withdrawal [2].
  • Observation of COS7 cells expressing green fluorescent protein- or Myc-tagged GBP showed that GBP was localized in the endoplasmic reticulum-Golgi domain where BODIPY 558/568 (4,4-difluro-5-(2-thienyl)-4-bora-3alpha,4alpha-diaza-S-indacene)-labeled brefeldin A accumulated [2].
  • It was shown that GAP possessed greater binding specificity than distamycin A, netropsin, Apy and GBP [3].
 

Associations of TMEM132A with chemical compounds

  • A pyrrolepolyamide-deoxyguanosine hybrid using the 3-aminopropyl linker (GAP) was designed and synthesized on the basis of previously reported results of a pyrrolepolyamide-adenosine hybrid (Apy) and a pyrrolepolyamide-deoxyguanoside hybrid using the 3-aminopropionyl linker (GBP) [3].
 

Analytical, diagnostic and therapeutic context of TMEM132A

  • Gastric bypass (RY-GBP) has a very small gastric pouch with a 1-cm diameter Roux-Y gastrojejunostomy [1].

References

  1. Gastric bypass for treating severe obesity. Sugerman, H.J., Kellum, J.M., Engle, K.M., Wolfe, L., Starkey, J.V., Birkenhauer, R., Fletcher, P., Sawyer, M.J. Am. J. Clin. Nutr. (1992) [Pubmed]
  2. Cloning and characterization of a novel GRP78-binding protein in the rat brain. Oh-hashi, K., Naruse, Y., Amaya, F., Shimosato, G., Tanaka, M. J. Biol. Chem. (2003) [Pubmed]
  3. Design, synthesis and analysis of a pyrrolepolyamide-nucleoside hybrid. Ohba, Y., Terui, Y., Kamaike, K., Oshima, T., Kawashima, E. Nucleic acids symposium series (2004) (2004) [Pubmed]
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