The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SMPD3  -  sphingomyelin phosphodiesterase 3, neutral...

Homo sapiens

Synonyms: NSMASE2, Neutral sphingomyelinase 2, Neutral sphingomyelinase II, Sphingomyelin phosphodiesterase 3, nSMase-2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on SMPD3

  • Our knowledge of SMPD3 function is consistent with the pathology observed in mutant mice and provides new insight into human pathologies [1].
  • Our studies suggest that SMPD3 is segregated into detergent-resistant subdomains of Golgi membranes of hypothalamic neurosecretory neurons, where its transient activation modifies the lipid bilayer, an essential step in the Golgi secretory pathway [2].
  • In this study, nSMase2 was found to translocate acutely to the plasma membrane of A549 epithelial cells in response to tumor necrosis factor alpha (TNF-alpha) in a time- and dose-dependent manner [3].
  • However, there is little information on the physiological regulation and roles of the cloned N-SMase enzyme, nSMase2 [3].
  • The neutral sphingomyelinases (nSMases) are considered major candidates for mediating the stress-induced production of ceramide. nSMase2, which has two hydrophobic segments near the NH(2)-terminal region, has been reported to be located at the plasma membrane and play important roles in ceramide-mediated signaling [4].

Biological context of SMPD3


Anatomical context of SMPD3


Associations of SMPD3 with chemical compounds


  1. A deletion in the gene encoding sphingomyelin phosphodiesterase 3 (Smpd3) results in osteogenesis and dentinogenesis imperfecta in the mouse. Aubin, I., Adams, C.P., Opsahl, S., Septier, D., Bishop, C.E., Auge, N., Salvayre, R., Negre-Salvayre, A., Goldberg, M., Guénet, J.L., Poirier, C. Nat. Genet. (2005) [Pubmed]
  2. Neutral sphingomyelinase 2 (smpd3) in the control of postnatal growth and development. Stoffel, W., Jenke, B., Blöck, B., Zumbansen, M., Koebke, J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Role for Neutral Sphingomyelinase-2 in Tumor Necrosis Factor {alpha}-Stimulated Expression of Vascular Cell Adhesion Molecule-1 (VCAM) and Intercellular Adhesion Molecule-1 (ICAM) in Lung Epithelial Cells: p38 MAPK IS AN UPSTREAM REGULATOR OF nSMase2. Clarke, C.J., Truong, T.G., Hannun, Y.A. J. Biol. Chem. (2007) [Pubmed]
  4. Neutral Sphingomyelinase 2 Is Palmitoylated on Multiple Cysteine Residues: ROLE OF PALMITOYLATION IN SUBCELLULAR LOCALIZATION. Tani, M., Hannun, Y.A. J. Biol. Chem. (2007) [Pubmed]
  5. nSMase2 activation and trafficking are modulated by oxidative stress to induce apoptosis. Levy, M., Castillo, S.S., Goldkorn, T. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  6. Endothelial nitric oxide synthase activation by tumor necrosis factor alpha through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors: a novel pathway relevant to the pathophysiology of endothelium. De Palma, C., Meacci, E., Perrotta, C., Bruni, P., Clementi, E. Arterioscler. Thromb. Vasc. Biol. (2006) [Pubmed]
  7. Analysis of membrane topology of neutral sphingomyelinase 2. Tani, M., Hannun, Y.A. FEBS Lett. (2007) [Pubmed]
WikiGenes - Universities