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SMPD2  -  sphingomyelin phosphodiesterase 2, neutral...

Homo sapiens

Synonyms: ISC1, Lyso-PAF-PLC, Lyso-platelet-activating factor-phospholipase C, N-SMase, NSMASE, ...
 
 
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Disease relevance of SMPD2

 

Psychiatry related information on SMPD2

 

High impact information on SMPD2

 

Chemical compound and disease context of SMPD2

 

Biological context of SMPD2

 

Anatomical context of SMPD2

 

Associations of SMPD2 with chemical compounds

 

Regulatory relationships of SMPD2

 

Other interactions of SMPD2

 

Analytical, diagnostic and therapeutic context of SMPD2

  • Western immunoblot assays revealed that the monospecific polyclonal antibody against urinary N-SMase recognized both the urinary N-SMase and the membrane-bound N-SMase [19].
  • We believe that the molecular cloning and characterization of N-SMase cDNA will accelerate the process to define its role as a key regulator in apoptosis, lipid and lipoprotein metabolism, and other cell regulatory pathways [15].
  • In enzyme-linked immunosorbent assays, the purified N-SMase used as an antigen was as effective as crude protein antigens in detecting human antibodies to H. pylori [28].
  • By cell fractionation, we demonstrate that, in addition to a previously reported minute amount of acidic sphingomyelinase activity, a substantial amount of neutral sphingomyelinase activity resides in caveolae of human skin fibroblasts [24].
  • Despite considerable research into N-SMase activity in cell culture and various tissues, the lack, until recently, of molecular identification of specific N-SMase enzymes had precluded specific insights into the regulation, physiological, and pathological roles of these proteins [29].

References

  1. Acid sphingomyelinase activation requires caspase-8 but not p53 nor reactive oxygen species during Fas-induced apoptosis in human glioma cells. Sawada, M., Nakashima, S., Kiyono, T., Yamada, J., Hara, S., Nakagawa, M., Shinoda, J., Sakai, N. Exp. Cell Res. (2002) [Pubmed]
  2. Familial adenomatous polyposis is associated with a marked decrease in alkaline sphingomyelinase activity: a key factor to the unrestrained cell proliferation? Hertervig, E., Nilsson, A., Björk, J., Hultkrantz, R., Duan, R.D. Br. J. Cancer (1999) [Pubmed]
  3. Enzyme activities and phospholipid storage patterns in brain and spleen samples from Niemann-Pick disease variants: a comparison of neuropathic and non-neuropathic forms. Besley, G.T., Elleder, M. J. Inherit. Metab. Dis. (1986) [Pubmed]
  4. Positive feedback control of neutral sphingomyelinase activity by ceramide. Jaffrézou, J.P., Maestre, N., de Mas-Mansat, V., Bezombes, C., Levade, T., Laurent, G. FASEB J. (1998) [Pubmed]
  5. Crystal structure of SmcL, a bacterial neutral sphingomyelinase C from Listeria. Openshaw, A.E., Race, P.R., Monzó, H.J., Vázquez-Boland, J.A., Banfield, M.J. J. Biol. Chem. (2005) [Pubmed]
  6. Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease. Jana, A., Pahan, K. J. Biol. Chem. (2004) [Pubmed]
  7. A role for neutral sphingomyelinase-mediated ceramide production in T cell receptor-induced apoptosis and mitogen-activated protein kinase-mediated signal transduction. Tonnetti, L., Verí, M.C., Bonvini, E., D'Adamio, L. J. Exp. Med. (1999) [Pubmed]
  8. Protein kinase Cdelta amplifies ceramide formation via mitochondrial signaling in prostate cancer cells. Sumitomo, M., Ohba, M., Asakuma, J., Asano, T., Kuroki, T., Asano, T., Hayakawa, M. J. Clin. Invest. (2002) [Pubmed]
  9. Endothelial apoptosis induced by inhibition of integrins alphavbeta3 and alphavbeta5 involves ceramide metabolic pathways. Erdreich-Epstein, A., Tran, L.B., Cox, O.T., Huang, E.Y., Laug, W.E., Shimada, H., Millard, M. Blood (2005) [Pubmed]
  10. Penta-acetyl geniposide induce apoptosis in C6 glioma cells by modulating the activation of neutral sphingomyelinase-induced p75 nerve growth factor receptor and protein kinase Cdelta pathway. Peng, C.H., Huang, C.N., Hsu, S.P., Wang, C.J. Mol. Pharmacol. (2006) [Pubmed]
  11. The phosphoinositide 3-kinase/Akt pathway is activated by daunorubicin in human acute myeloid leukemia cell lines. Plo, I., Bettaïeb, A., Payrastre, B., Mansat-De Mas, V., Bordier, C., Rousse, A., Kowalski-Chauvel, A., Laurent, G., Lautier, D. FEBS Lett. (1999) [Pubmed]
  12. Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis. Jensen, J.M., Fölster-Holst, R., Baranowsky, A., Schunck, M., Winoto-Morbach, S., Neumann, C., Schütze, S., Proksch, E. J. Invest. Dermatol. (2004) [Pubmed]
  13. Effects of ceramide inhibition on radiation-induced apoptosis in human leukemia MOLT-4 cells. Takahashi, E., Inanami, O., Asanuma, T., Kuwabara, M. J. Radiat. Res. (2006) [Pubmed]
  14. Activation of a plasma membrane-associated neutral sphingomyelinase and concomitant ceramide accumulation during IgG-dependent phagocytosis in human polymorphonuclear leukocytes. Hinkovska-Galcheva, V., Kjeldsen, L., Mansfield, P.J., Boxer, L.A., Shayman, J.A., Suchard, S.J. Blood (1998) [Pubmed]
  15. Molecular cloning, characterization, and expression of a novel human neutral sphingomyelinase. Chatterjee, S., Han, H., Rollins, S., Cleveland, T. J. Biol. Chem. (1999) [Pubmed]
  16. Neutral and acid sphingomyelinases: somatotopographical distribution in human brain and distribution in rat organs. A possible relationship with the dopamine system. Spence, M.W., Burgess, J.K., Sperker, E.R. Brain Res. (1979) [Pubmed]
  17. Characterization of acidic and neutral sphingomyelinase activities in crude extracts of HL-60 cells. Samet, D., Barenholz, Y. Chem. Phys. Lipids (1999) [Pubmed]
  18. Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism. Marchesini, N., Luberto, C., Hannun, Y.A. J. Biol. Chem. (2003) [Pubmed]
  19. Neutral sphingomyelinase from human urine. Purification and preparation of monospecific antibodies. Chatterjee, S., Ghosh, N. J. Biol. Chem. (1989) [Pubmed]
  20. Effects of gentamicin on sphingomyelinase activity in cultured human renal proximal tubular cells. Ghosh, P., Chatterjee, S. J. Biol. Chem. (1987) [Pubmed]
  21. Thalidomide-induced antiangiogenic action is mediated by ceramide through depletion of VEGF receptors, and is antagonized by sphingosine-1-phosphate. Yabu, T., Tomimoto, H., Taguchi, Y., Yamaoka, S., Igarashi, Y., Okazaki, T. Blood (2005) [Pubmed]
  22. Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis. Puglielli, L., Ellis, B.C., Saunders, A.J., Kovacs, D.M. J. Biol. Chem. (2003) [Pubmed]
  23. Lactosylceramide is required in apoptosis induced by N-Smase. Martin, S.F., Williams, N., Chatterjee, S. Glycoconj. J. (2006) [Pubmed]
  24. A neutral sphingomyelinase resides in sphingolipid-enriched microdomains and is inhibited by the caveolin-scaffolding domain: potential implications in tumour necrosis factor signalling. Veldman, R.J., Maestre, N., Aduib, O.M., Medin, J.A., Salvayre, R., Levade, T. Biochem. J. (2001) [Pubmed]
  25. p53-Independent ceramide formation in human glioma cells during gamma-radiation-induced apoptosis. Hara, S., Nakashima, S., Kiyono, T., Sawada, M., Yoshimura, S., Iwama, T., Banno, Y., Shinoda, J., Sakai, N. Cell Death Differ. (2004) [Pubmed]
  26. Activation of acid sphingomyelinase by interleukin-1 (IL-1) requires the IL-1 receptor accessory protein. Hofmeister, R., Wiegmann, K., Korherr, C., Bernardo, K., Krönke, M., Falk, W. J. Biol. Chem. (1997) [Pubmed]
  27. Caenorhabditis elegans contains two distinct acid sphingomyelinases. Lin, X., Hengartner, M.O., Kolesnick, R. J. Biol. Chem. (1998) [Pubmed]
  28. Purification and characterization of neutral sphingomyelinase from Helicobacter pylori. Chan, E.C., Chang, C.C., Li, Y.S., Chang, C.A., Chiou, C.C., Wu, T.Z. Biochemistry (2000) [Pubmed]
  29. The extended family of neutral sphingomyelinases. Clarke, C.J., Snook, C.F., Tani, M., Matmati, N., Marchesini, N., Hannun, Y.A. Biochemistry (2006) [Pubmed]
 
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