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Gene Review

PDGFB  -  platelet-derived growth factor beta...

Homo sapiens

Synonyms: IBGC5, PDGF subunit B, PDGF-2, PDGF2, Platelet-derived growth factor B chain, ...
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Disease relevance of PDGFB


Psychiatry related information on PDGFB

  • We studied the relationships between structure and schizotypal features (assessed using RISC and SIS) and verbal learning and memory (measured using RAVLT) in relatives at high risk of developing schizophrenia and normal controls [6].
  • CONCLUSIONS: The SIS 2.0 and SIS-16 had good psychometric properties with support for the internal consistency and validity of both measures [7].

High impact information on PDGFB


Chemical compound and disease context of PDGFB


Biological context of PDGFB

  • DFSP and GCF tumors are genetically characterized by chromosomal rearrangements fusing the collagen type Ialpha1 (COLIA1) gene to the platelet-derived growth factor B-chain (PDGFB) gene [16].
  • The PDGFA and PDGFB mRNA expression in the hybrid cells was markedly suppressed, indicating that the melanoma PDGF genes are controlled in the hybrid cells by negative factors/mechanisms contributed by the fibroblast genome [11].
  • The two other members of this gene family, the PDGFB receptor and the colony stimulating factor-1 (CSF1) receptor, are closely linked on the distal half of the long arm of chromosome 5 [17].
  • It is characterized by the presence of ring chromosomes or chromosomal translocations fusing the promoter of the collagen gene COL1A1 to the platelet-derived growth factor beta-chain gene PDGFB, increasing the production of PDGF locally and promoting autocrine or paracrine tumor growth [18].
  • We speculate that the biological consequences of the mutant PDGFB allele contributed to the unique disease phenotype of the translocation patient [19].

Anatomical context of PDGFB

  • Identification and characterization of an essential, activating regulatory element of the human SIS/PDGFB promoter in human megakaryocytes [20].
  • The PDGFB, PDGFA, and stem cell factor cognate ligands were investigated by reverse transcription-PCR, and gene status was assessed by fluorescence in situ hybridization [21].
  • In total RNA isolated from lymphocytes of the translocation patient, we identified four different fusion transcripts consisting of PDGFB exons and parts of chromosome 1q24 [19].
  • Detection of COL1A1-PDGFB fusion transcripts and platelet-derived growth factor alpha and beta receptors in giant cell fibroblastoma of the postsacrococcygeal region [22].
  • A human clone, c-sis clone 8, which contains all of the v-sis-related sequences present in human DNA, was transcriptionally inactive when transfected into NIH/3T3 cells [4].

Associations of PDGFB with chemical compounds

  • PURPOSE: We have previously shown the presence of an activated platelet-derived growth factor (PDGF) receptor (PDGFR) B and its ligand PDGFB in a limited number of patients with clinical and radiological responses to imatinib mesylate treatment [21].
  • Immunocytochemical studies using markers specific to endothelium (Ulex europaeus I lectin, Factor VIII related antigen), and smooth muscle (alpha-smooth muscle actin), indicate that the PDGF B-chain and PDGFR beta are both expressed primarily by mesangial cells [23].
  • To test this hypothesis, a reverse transcription-polymerase chain reaction (RT-PCR) assay was conducted to determine whether COL1A1-PDGFB fusion transcripts could be detected in six cases of SAF, using archival formalin-fixed, paraffin-embedded tissues [24].
  • The degree of inhibition of both basal and lipopolysaccharide-induced PDGF-B-chain expression increased with the extent of LDL oxidation [25].
  • Previous work in our laboratory has demonstrated that PDGF B chain mRNA expression is stimulated in microvascular endothelial cells by phorbol esters (PMA), thrombin, and transforming growth factor-beta (TGF-beta) and blocked by agents that elevate cyclic AMP (cAMP) [26].

Regulatory relationships of PDGFB


Other interactions of PDGFB


Analytical, diagnostic and therapeutic context of PDGFB


  1. Induction of growth factor RNA expression in human malignant melanoma: markers of transformation. Albino, A.P., Davis, B.M., Nanus, D.M. Cancer Res. (1991) [Pubmed]
  2. Shear stress magnitude and directionality modulate growth factor gene expression in preconditioned vascular endothelial cells. Passerini, A.G., Milsted, A., Rittgers, S.E. J. Vasc. Surg. (2003) [Pubmed]
  3. Dermatofibrosarcoma protuberans with COL1A1 (exon 18) -PDGFB (exon 2) fusion transcript. Saeki, H., Ohmatsu, H., Hoashi, T., Asano, N., Idezuki, T., Kawabata, Y., Asahina, A., Kikuchi, K., Tamaki, K. Br. J. Dermatol. (2003) [Pubmed]
  4. Expression of the normal human sis/PDGF-2 coding sequence induces cellular transformation. Gazit, A., Igarashi, H., Chiu, I.M., Srinivasan, A., Yaniv, A., Tronick, S.R., Robbins, K.C., Aaronson, S.A. Cell (1984) [Pubmed]
  5. Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis. Collins, T., Ginsburg, D., Boss, J.M., Orkin, S.H., Pober, J.S. Nature (1985) [Pubmed]
  6. Brain-behaviour relationships in people at high genetic risk of schizophrenia. Lymer, G.K., Job, D.E., William, T., Moorhead, J., McIntosh, A.M., Owens, D.G., Johnstone, E.C., Lawrie, S.M. Neuroimage (2006) [Pubmed]
  7. Internal consistency and validity of the Stroke Impact Scale 2.0 (SIS 2.0) and SIS-16 in an Australian sample. Edwards, B., O'Connell, B. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. (2003) [Pubmed]
  8. Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma. Simon, M.P., Pedeutour, F., Sirvent, N., Grosgeorge, J., Minoletti, F., Coindre, J.M., Terrier-Lacombe, M.J., Mandahl, N., Craver, R.D., Blin, N., Sozzi, G., Turc-Carel, C., O'Brien, K.P., Kedra, D., Fransson, I., Guilbaud, C., Dumanski, J.P. Nat. Genet. (1997) [Pubmed]
  9. PDGF B-chain in neurons of the central nervous system, posterior pituitary, and in a transgenic model. Sasahara, M., Fries, J.W., Raines, E.W., Gown, A.M., Westrum, L.E., Frosch, M.P., Bonthron, D.T., Ross, R., Collins, T. Cell (1991) [Pubmed]
  10. Production of platelet-derived growth factor-like mitogen by smooth-muscle cells from human atheroma. Libby, P., Warner, S.J., Salomon, R.N., Birinyi, L.K. N. Engl. J. Med. (1988) [Pubmed]
  11. Negative trans-acting mechanisms controlling expression of platelet-derived growth factor A and B MRNA in somatic cell hybrids. Levéen, P., Betsholtz, C., Westermark, B. Exp. Cell Res. (1993) [Pubmed]
  12. Detection of COL1A1-PDGFB fusion transcripts in dermatofibrosarcoma protuberans by reverse transcription-polymerase chain reaction using archival formalin-fixed, paraffin-embedded tissues. Wang, J., Hisaoka, M., Shimajiri, S., Morimitsu, Y., Hashimoto, H. Diagn. Mol. Pathol. (1999) [Pubmed]
  13. Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans. Rubin, B.P., Schuetze, S.M., Eary, J.F., Norwood, T.H., Mirza, S., Conrad, E.U., Bruckner, J.D. J. Clin. Oncol. (2002) [Pubmed]
  14. Sustained complete remission of metastatic dermatofibrosarcoma protuberans with imatinib mesylate. Labropoulos, S.V., Fletcher, J.A., Oliveira, A.M., Papadopoulos, S., Razis, E.D. Anticancer Drugs (2005) [Pubmed]
  15. The cell cycle dependence of c-sis gene expression: artifactual conclusions in cells prepared by chemical but not physical techniques. Press, R.D., Jacobberger, J.W., Samols, D., Goldthwait, D. Cell and tissue kinetics. (1990) [Pubmed]
  16. Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis. Sjöblom, T., Shimizu, A., O'Brien, K.P., Pietras, K., Dal Cin, P., Buchdunger, E., Dumanski, J.P., Ostman, A., Heldin, C.H. Cancer Res. (2001) [Pubmed]
  17. Human PDGFA receptor gene maps to the same region on chromosome 4 as the KIT oncogene. Stenman, G., Eriksson, A., Claesson-Welsh, L. Genes Chromosomes Cancer (1989) [Pubmed]
  18. Differential sensitivity to imatinib of 2 patients with metastatic sarcoma arising from dermatofibrosarcoma protuberans. Maki, R.G., Awan, R.A., Dixon, R.H., Jhanwar, S., Antonescu, C.R. Int. J. Cancer (2002) [Pubmed]
  19. Disruption of the PDGFB gene in a 1;22 translocation patient does not cause Costello syndrome. Sutajová, M., Neukirchen, U., Meinecke, P., Czeizel, A.E., Tímár, L., Sólyom, E., Gal, A., Kutsche, K. Genomics (2004) [Pubmed]
  20. Identification and characterization of an essential, activating regulatory element of the human SIS/PDGFB promoter in human megakaryocytes. Jin, H.M., Brady, M.L., Fahl, W.E. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  21. Molecular and Biochemical Analyses of Platelet-Derived Growth Factor Receptor (PDGFR) B, PDGFRA, and KIT Receptors in Chordomas. Tamborini, E., Miselli, F., Negri, T., Lagonigro, M.S., Staurengo, S., Dagrada, G.P., Stacchiotti, S., Pastore, E., Gronchi, A., Perrone, F., Carbone, A., Pierotti, M.A., Casali, P.G., Pilotti, S. Clin. Cancer Res. (2006) [Pubmed]
  22. Detection of COL1A1-PDGFB fusion transcripts and platelet-derived growth factor alpha and beta receptors in giant cell fibroblastoma of the postsacrococcygeal region. Kashima, A., Yamashita, A., Moriguchi, S., Marutsuka, K., Tsumori, S., Yoshizato, K., Ishihara, A., Setoyama, M., Asada, Y. Br. J. Dermatol. (2006) [Pubmed]
  23. Developmental patterns of PDGF B-chain, PDGF-receptor, and alpha-actin expression in human glomerulogenesis. Alpers, C.E., Seifert, R.A., Hudkins, K.L., Johnson, R.J., Bowen-Pope, D.F. Kidney Int. (1992) [Pubmed]
  24. Expression of COL1A1-PDGFB fusion transcripts in superficial adult fibrosarcoma suggests a close relationship to dermatofibrosarcoma protuberans. Sheng, W.Q., Hashimoto, H., Okamoto, S., Ishida, T., Meis-Kindblom, J.M., Kindblom, L.G., Hisaoka, M. J. Pathol. (2001) [Pubmed]
  25. The influence of oxidatively modified low density lipoproteins on expression of platelet-derived growth factor by human monocyte-derived macrophages. Malden, L.T., Chait, A., Raines, E.W., Ross, R. J. Biol. Chem. (1991) [Pubmed]
  26. Regulated expression of the platelet-derived growth factor A chain gene in microvascular endothelial cells. Starksen, N.F., Harsh, G.R., Gibbs, V.C., Williams, L.T. J. Biol. Chem. (1987) [Pubmed]
  27. Regulation of platelet-derived growth factor gene expression by transforming growth factor beta and phorbol ester in human leukemia cell lines. Mäkelä, T.P., Alitalo, R., Paulsson, Y., Westermark, B., Heldin, C.H., Alitalo, K. Mol. Cell. Biol. (1987) [Pubmed]
  28. Differential binding and regulation of platelet-derived growth factor A and B chain isoforms by alpha 2-macroglobulin. Bonner, J.C., Osornio-Vargas, A.R. J. Biol. Chem. (1995) [Pubmed]
  29. Expression of PDGF and PDGF receptor mRNA in glomeruli in IgA nephropathy. Terada, Y., Yamada, T., Nakashima, O., Sasaki, S., Nonoguchi, H., Tomita, K., Marumo, F. J. Am. Soc. Nephrol. (1997) [Pubmed]
  30. Control of the expression of c-sis mRNA in human glioblastoma cells by phorbol ester and transforming growth factor beta 1. Press, R.D., Misra, A., Gillaspy, G., Samols, D., Goldthwait, D.A. Cancer Res. (1989) [Pubmed]
  31. Cytokine production in cerebrospinal fluid after subarachnoid haemorrhage. Kikuchi, T., Okuda, Y., Kaito, N., Abe, T. Neurol. Res. (1995) [Pubmed]
  32. Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance. Maxwell, M., Naber, S.P., Wolfe, H.J., Galanopoulos, T., Hedley-Whyte, E.T., Black, P.M., Antoniades, H.N. J. Clin. Invest. (1990) [Pubmed]
  33. Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation. Hermansson, M., Nistér, M., Betsholtz, C., Heldin, C.H., Westermark, B., Funa, K. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  34. Association of markers for TGFbeta3, TGFbeta2 and TIMP1 with systemic sclerosis. Susol, E., Rands, A.L., Herrick, A., McHugh, N., Barrett, J.H., Ollier, W.E., Worthington, J. Rheumatology (Oxford, England) (2000) [Pubmed]
  35. Analysis of gene mutations in three cases of dermatofibrosarcoma protuberans (DFSP): ordinary DFSP, DFSP with fibrosarcomatous lesion (DFSP-FS) and lung metastasis of DFSP-FS. Saeki, H., Hoashi, T., Tada, Y., Ashida, R., Kuwano, Y., Le Pavoux, A., Tsunemi, Y., Shikada, J., Torii, H., Kawabata, Y., Kikuchi, K., Tamada, Y., Matsumoto, Y., Tamaki, K. J. Dermatol. Sci. (2003) [Pubmed]
  36. Transforming activity of the chimeric sequence formed by the fusion of collagen gene COL1A1 and the platelet derived growth factor b-chain gene in dermatofibrosarcoma protuberans. Greco, A., Fusetti, L., Villa, R., Sozzi, G., Minoletti, F., Mauri, P., Pierotti, M.A. Oncogene (1998) [Pubmed]
  37. COL1A1-PDGFB fusion in a ring chromosome 4 found in a dermatofibrosarcoma protuberans. Navarro, M., Simon, M.P., Migeon, C., Turc-Carel, C., Pedeutour, F. Genes Chromosomes Cancer (1998) [Pubmed]
  38. Expression of recombinant platelet-derived growth factor A- and B-chain homodimers in rat-1 cells and human fibroblasts reveals differences in protein processing and autocrine effects. Bywater, M., Rorsman, F., Bongcam-Rudloff, E., Mark, G., Hammacher, A., Heldin, C.H., Westermark, B., Betsholtz, C. Mol. Cell. Biol. (1988) [Pubmed]
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