The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

LANCL2  -  LanC lantibiotic synthetase component C...

Homo sapiens

Synonyms: GPR69B, LanC-like protein 2, TASP, Testis-specific adriamycin sensitivity protein
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of LANCL2

  • LANCL2 (LANC-like 2) is a bystander gene that is coamplified and overexpressed with epidermal growth factor receptor in approximately 20% of all glioblastomas [1].
  • The TASP approach to mammary augmentation offers distinct, clinically confirmed advantages of locating the scar off the breast, minimizing loss of nipple sensation, and reducing risks of hematoma and infection [2].

High impact information on LANCL2

  • The TASP conformation and its orientation in self-assembled monolayers (SAMs) play a central role for the accessibility of these serine residues [3].
  • Unlike in methanol, the melittin-TASP self-aggregates in water [4].
  • These states are likely to be formed by aggregated TASP structures as inferred from a strongly voltage-dependent channel activity on membranes of large area [4].
  • A comparison of the retention times of these side-products and the results of pre-column denaturation experiments indicated that the tertiary structure of the TASP molecule is maintained on binding to biphenyl and C4 columns [5].
  • The orientation of the lysine side chains within preferential geometries of the individual templates is analyzed and a tentative evaluation for their potential to stabilize TASP molecules of 4-helix bundle topology is given [6].

Anatomical context of LANCL2

  • Interestingly, the non-myristoylated protein was confined to the nucleus indicating that the myristoylation targets LANCL2 to the plasma membrane [7].
  • We found that overexpressed LANCL2 interacts with the cortical actin cytoskeleton and therefore may play a role in cytoskeleton reorganization and in consequence to cell detachment [7].
  • Expression studies of tagged LANCL2 revealed the major localization to the plasma membrane, juxta-nuclear vesicles, and the nucleus, in contrast to the homologue LANCL1 that was mainly found in the cytosol and nucleus [7].

Associations of LANCL2 with chemical compounds

  • Moreover, we confirmed previous data that LANCL2 overexpression enhances the cellular sensitivity to the anticancer drug adriamycin and found that this sensitivity is dependent on the myristoylation and membrane association of LANCL2 [7].
  • Cholesterol depletion by methyl-beta-cyclodextrin caused the partial dissociation of overexpressed LANCL2 from the plasma membrane in vitro, whereas in vivo we observed an enhanced cell detachment from the matrix [7].
  • Versatile synthesis of Boc protected hydrazinoacetic acid and its application to the chemoselective ligation of TASP molecules [8].
  • This paper describes a convenient synthesis of protected hydrazine derivatives, i.e. 1,2-bis-Boc-hydrazinoacetic acid, and its application for hydrazone ligation techniques in convergent template assembled synthetic protein (TASP) synthesis [8].

Other interactions of LANCL2


Analytical, diagnostic and therapeutic context of LANCL2

  • The quantitative analysis of the individual TASP molecules by high performance liquid chromatography (HPLC) and electrospray mass spectrometry (ES-MS) allows the delineation of the role of complementary packing in helix bundle formation [10].


  1. Lanthionine synthetase components C-like 2 increases cellular sensitivity to adriamycin by decreasing the expression of P-glycoprotein through a transcription-mediated mechanism. Park, S., James, C.D. Cancer Res. (2003) [Pubmed]
  2. Transaxillary subpectoral augmentation mammaplasty: a 9-year experience. Tebbetts, J.B. Clinics in plastic surgery. (1988) [Pubmed]
  3. Orientation modulation of a synthetic polypeptide in self-assembled monolayers: a TOF-SIMS study. Leufgen, K., Mutter, M., Vogel, H., Szymczak, W. J. Am. Chem. Soc. (2003) [Pubmed]
  4. Template-assembled melittin: structural and functional characterization of a designed, synthetic channel-forming protein. Pawlak, M., Meseth, U., Dhanapal, B., Mutter, M., Vogel, H. Protein Sci. (1994) [Pubmed]
  5. Retention behaviour of a template-assembled synthetic protein and its amphiphilic building blocks on reversed-phase columns. Steiner, V., Schär, M., Börnsen, K.O., Mutter, M. J. Chromatogr. (1991) [Pubmed]
  6. Molecular dynamics conformational search of six cyclic peptides used in the template assembled synthetic protein approach for protein de novo design. Floegel, R., Mutter, M. Biopolymers (1992) [Pubmed]
  7. Myristoylation of human LanC-like Protein 2 (LANCL2) is essential for the interaction with the plasma membrane and the increase in cellular sensitivity to adriamycin. Landlinger, C., Salzer, U., Prohaska, R. Biochim. Biophys. Acta (2006) [Pubmed]
  8. Versatile synthesis of Boc protected hydrazinoacetic acid and its application to the chemoselective ligation of TASP molecules. Banfi, D., Mutter, M., Patiny, L. Protein Pept. Lett. (2004) [Pubmed]
  9. Molecular cloning, characterization, and tissue-specific expression of human LANCL2, a novel member of the LanC-like protein family. Mayer, H., Pongratz, M., Prohaska, R. DNA Seq. (2001) [Pubmed]
  10. Protein design and folding: template trapping of self-assembled helical bundles. Grell, D., Richardson, J.S., Mutter, M. J. Pept. Sci. (2001) [Pubmed]
WikiGenes - Universities