Disease relevance of LANCL2

• LANCL2 (LANC-like 2) is a bystander gene that is coamplified and overexpressed with epidermal growth factor receptor in approximately 20% of all glioblastomas [1].
• The TASP approach to mammary augmentation offers distinct, clinically confirmed advantages of locating the scar off the breast, minimizing loss of nipple sensation, and reducing risks of hematoma and infection [2].

High impact information on LANCL2

• The TASP conformation and its orientation in self-assembled monolayers (SAMs) play a central role for the accessibility of these serine residues [3].
• Unlike in methanol, the melittin-TASP self-aggregates in water [4].
• These states are likely to be formed by aggregated TASP structures as inferred from a strongly voltage-dependent channel activity on membranes of large area [4].
• A comparison of the retention times of these side-products and the results of pre-column denaturation experiments indicated that the tertiary structure of the TASP molecule is maintained on binding to biphenyl and C4 columns [5].
• The orientation of the lysine side chains within preferential geometries of the individual templates is analyzed and a tentative evaluation for their potential to stabilize TASP molecules of 4-helix bundle topology is given [6].

Anatomical context of LANCL2

• Interestingly, the non-myristoylated protein was confined to the nucleus indicating that the myristoylation targets LANCL2 to the plasma membrane [7].
• We found that overexpressed LANCL2 interacts with the cortical actin cytoskeleton and therefore may play a role in cytoskeleton reorganization and in consequence to cell detachment [7].
• Expression studies of tagged LANCL2 revealed the major localization to the plasma membrane, juxta-nuclear vesicles, and the nucleus, in contrast to the homologue LANCL1 that was mainly found in the cytosol and nucleus [7].

Associations of LANCL2 with chemical compounds

• Moreover, we confirmed previous data that LANCL2 overexpression enhances the cellular sensitivity to the anticancer drug adriamycin and found that this sensitivity is dependent on the myristoylation and membrane association of LANCL2 [7].
• Cholesterol depletion by methyl-beta-cyclodextrin caused the partial dissociation of overexpressed LANCL2 from the plasma membrane in vitro, whereas in vivo we observed an enhanced cell detachment from the matrix [7].
• Versatile synthesis of Boc protected hydrazinoacetic acid and its application to the chemoselective ligation of TASP molecules [8].
• This paper describes a convenient synthesis of protected hydrazine derivatives, i.e. 1,2-bis-Boc-hydrazinoacetic acid, and its application for hydrazone ligation techniques in convergent template assembled synthetic protein (TASP) synthesis [8].

Other interactions of LANCL2

• Molecular cloning, characterization, and tissue-specific expression of human LANCL2, a novel member of the LanC-like protein family [9].

Analytical, diagnostic and therapeutic context of LANCL2

• The quantitative analysis of the individual TASP molecules by high performance liquid chromatography (HPLC) and electrospray mass spectrometry (ES-MS) allows the delineation of the role of complementary packing in helix bundle formation [10].

References