The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

LANCL1  -  LanC lantibiotic synthetase component C...

Homo sapiens

Synonyms: 40 kDa erythrocyte membrane protein, GPR69A, LanC-like protein 1, p40
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of LANCL1

  • We describe the construction of an adeno-associated virus (AAV) vector in which the coding sequence of the procaryotic gene neo is expressed under the control of the major AAV promoter p40 [1].
  • In addition to these species, B-capsids contain a 36,000-molecular-weight (36K) protein which has been designated as the HCMV "assembly protein," based on its similarities to counterparts in strain Colburn CMV (i.e., 37K protein) and herpes simplex virus (i.e., VP22a/p40/NC-3/ICP35e) [2].

High impact information on LANCL1

  • In particular, the high expression of LANCL1 in testis and brain, organs separated by blood-tissue barriers, may hint at a role in the immune surveillance of these organs [3].
  • LANCL1, an erythrocyte protein recruited to the Maurer's clefts during Plasmodium falciparum development [4].
  • Expression studies of tagged LANCL2 revealed the major localization to the plasma membrane, juxta-nuclear vesicles, and the nucleus, in contrast to the homologue LANCL1 that was mainly found in the cytosol and nucleus [5].
  • IL-12B gene, which encodes the p40 subunit of IL-12, is located at chromosome 5q31-33 [6].
  • We isolated a 40 kDa integral membrane protein (p40) from human erythrocyte ghosts by affinity chromatography, using a C-terminal peptide of stomatin, and obtained partial sequences which enabled us to isolate two full-length cDNAs from human bone marrow and fetal brain cDNA libraries [7].

Biological context of LANCL1


Anatomical context of LANCL1

  • PfSBP1 is an integral membrane protein of the clefts, interacting with an erythrocyte cytosolic protein, identified here as the human Lantibiotic synthetase component C-like protein LANCL1 [4].

Associations of LANCL1 with chemical compounds

  • Characterization of rat LANCL1, a novel member of the lanthionine synthetase C-like protein family, highly expressed in testis and brain [3].

Analytical, diagnostic and therapeutic context of LANCL1


  1. Adeno-associated virus vector for high-frequency integration, expression, and rescue of genes in mammalian cells. Tratschin, J.D., Miller, I.L., Smith, M.G., Carter, B.J. Mol. Cell. Biol. (1985) [Pubmed]
  2. Isolation of human cytomegalovirus intranuclear capsids, characterization of their protein constituents, and demonstration that the B-capsid assembly protein is also abundant in noninfectious enveloped particles. Irmiere, A., Gibson, W. J. Virol. (1985) [Pubmed]
  3. Characterization of rat LANCL1, a novel member of the lanthionine synthetase C-like protein family, highly expressed in testis and brain. Mayer, H., Bauer, H., Breuss, J., Ziegler, S., Prohaska, R. Gene (2001) [Pubmed]
  4. LANCL1, an erythrocyte protein recruited to the Maurer's clefts during Plasmodium falciparum development. Blisnick, T., Vincensini, L., Barale, J.C., Namane, A., Braun Breton, C. Mol. Biochem. Parasitol. (2005) [Pubmed]
  5. Myristoylation of human LanC-like Protein 2 (LANCL2) is essential for the interaction with the plasma membrane and the increase in cellular sensitivity to adriamycin. Landlinger, C., Salzer, U., Prohaska, R. Biochim. Biophys. Acta (2006) [Pubmed]
  6. Interleukin-12B Gene Polymorphism does not Confer Susceptibility to Graves' Ophthalmopathy in Japanese Population. Hiromatsu, Y., Fukutani, T., Ichimura, M., Mukai, T., Kaku, H., Miyake, I., Yamada, K. Endocr. J. (2006) [Pubmed]
  7. Isolation, molecular characterization, and tissue-specific expression of a novel putative G protein-coupled receptor. Mayer, H., Salzer, U., Breuss, J., Ziegler, S., Marchler-Bauer, A., Prohaska, R. Biochim. Biophys. Acta (1998) [Pubmed]
  8. Annexins as regulators of invertebrate phototransduction. Hecker, C., Nuske, J.H., Stieve, H. Acta Histochem. Suppl. (1991) [Pubmed]
  9. Molecular cloning, characterization, and tissue-specific expression of human LANCL2, a novel member of the LanC-like protein family. Mayer, H., Pongratz, M., Prohaska, R. DNA Seq. (2001) [Pubmed]
WikiGenes - Universities