Disease relevance of LANCL1

• We describe the construction of an adeno-associated virus (AAV) vector in which the coding sequence of the procaryotic gene neo is expressed under the control of the major AAV promoter p40 [1].
• In addition to these species, B-capsids contain a 36,000-molecular-weight (36K) protein which has been designated as the HCMV "assembly protein," based on its similarities to counterparts in strain Colburn CMV (i.e., 37K protein) and herpes simplex virus (i.e., VP22a/p40/NC-3/ICP35e) [2].

High impact information on LANCL1

• In particular, the high expression of LANCL1 in testis and brain, organs separated by blood-tissue barriers, may hint at a role in the immune surveillance of these organs [3].
• LANCL1, an erythrocyte protein recruited to the Maurer's clefts during Plasmodium falciparum development [4].
• Expression studies of tagged LANCL2 revealed the major localization to the plasma membrane, juxta-nuclear vesicles, and the nucleus, in contrast to the homologue LANCL1 that was mainly found in the cytosol and nucleus [5].
• IL-12B gene, which encodes the p40 subunit of IL-12, is located at chromosome 5q31-33 [6].
• We isolated a 40 kDa integral membrane protein (p40) from human erythrocyte ghosts by affinity chromatography, using a C-terminal peptide of stomatin, and obtained partial sequences which enabled us to isolate two full-length cDNAs from human bone marrow and fetal brain cDNA libraries [7].

Biological context of LANCL1

• Methylation and consequent crosslinking of p40 and p48 to the cytoskeleton or to the plasma membrane seem to be regulated by phosphorylation [8].

Anatomical context of LANCL1

• PfSBP1 is an integral membrane protein of the clefts, interacting with an erythrocyte cytosolic protein, identified here as the human Lantibiotic synthetase component C-like protein LANCL1 [4].

Associations of LANCL1 with chemical compounds

• Characterization of rat LANCL1, a novel member of the lanthionine synthetase C-like protein family, highly expressed in testis and brain [3].

Analytical, diagnostic and therapeutic context of LANCL1

• The high level of expression of rat LANCL1 in these tissues was confirmed by Western blotting [3].
• Molecular cloning, characterization, and tissue-specific expression of human LANCL2, a novel member of the LanC-like protein family [9].

References