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SULF2  -  sulfatase 2

Homo sapiens

Synonyms: Extracellular sulfatase Sulf-2, HSULF-2, KIAA1247, SULF-2, UNQ559/PRO1120, ...
 
 
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Disease relevance of SULF2

 

High impact information on SULF2

 

Chemical compound and disease context of SULF2

 

Biological context of SULF2

 

Anatomical context of SULF2

  • To directly test the role of Sulfs in tumor growth control in vivo, a human myeloma cell line was transfected with cDNAs encoding either of the two known human endosulfatases, HSulf-1 or HSulf-2 [2].
  • In two mouse models of mammary carcinoma, Sulf-2 mRNA was upregulated in comparison to its expression in normal mammary gland [1].
  • In support of the possible mechanistic relevance of Sulf-2 upregulation in tumors, purified recombinant Sulf-2 promoted angiogenesis in the chick chorioallantoic membrane assay [1].
 

Associations of SULF2 with chemical compounds

  • Sulf-1 and Sulf-2 have been cloned and identified as sulfatases that release sulfate groups on the C-6 position of GlcNAc residue from an internal subdomain in intact heparin [7].
  • A new class of sulfatases, SulfFP1/sulf-1 and SulfFP2/sulf-2, has been implicated in the modulation of extracellular signaling by remodeling heparan sulfate through 6-O-endosulfatase activity [8].
  • We previously cloned a cDNA encoding a novel human endosulfatase, HSulf-2, which removes 6-O-sulfate groups on glucosamine from subregions of intact heparin [9].
 

Analytical, diagnostic and therapeutic context of SULF2

  • Degenerate primers designed from the motifs and the N-terminal amino acid sequence obtained were used to generate PCR fragments and to isolate both a full-length and a 3'-truncated cDNA encoding H. pomatia sulfatases, designated SULF1 and SULF2 [6].
  • To determine whether HSulf-2 modulates the interactions between heparin-binding factors and heparin, we developed an ELISA, in which soluble factors were allowed to bind to immobilized heparin [9].

References

  1. Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer. Morimoto-Tomita, M., Uchimura, K., Bistrup, A., Lum, D.H., Egeblad, M., Boudreau, N., Werb, Z., Rosen, S.D. Neoplasia (2005) [Pubmed]
  2. HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo. Dai, Y., Yang, Y., MacLeod, V., Yue, X., Rapraeger, A.C., Shriver, Z., Venkataraman, G., Sasisekharan, R., Sanderson, R.D. J. Biol. Chem. (2005) [Pubmed]
  3. Endosome-to-Golgi transport is regulated by protein kinase A type II alpha. Birkeli, K.A., Llorente, A., Torgersen, M.L., Keryer, G., Taskén, K., Sandvig, K. J. Biol. Chem. (2003) [Pubmed]
  4. Insulin modulates the secretion of proteins from mature 3T3-L1 adipocytes: a role for transcriptional regulation of processing. Wang, P., Keijer, J., Bunschoten, A., Bouwman, F., Renes, J., Mariman, E. Diabetologia (2006) [Pubmed]
  5. Compositional profiling of heparin/heparan sulfate using mass spectrometry: assay for specificity of a novel extracellular human endosulfatase. Saad, O.M., Ebel, H., Uchimura, K., Rosen, S.D., Bertozzi, C.R., Leary, J.A. Glycobiology (2005) [Pubmed]
  6. Cloning and characterization of two cDNAs encoding sulfatases in the Roman snail, Helix pomatia. Wittstock, U., Fischer, M., Svendsen, I., Halkier, B.A. IUBMB Life (2000) [Pubmed]
  7. Measuring the activities of the sulfs: two novel heparin/heparan sulfate endosulfatases. Uchimura, K., Morimoto-Tomita, M., Rosen, S.D. Meth. Enzymol. (2006) [Pubmed]
  8. Expression of a heparan sulfate remodeling enzyme, heparan sulfate 6-O-endosulfatase sulfatase FP2, in the rat nervous system. Nagamine, S., Koike, S., Keino-Masu, K., Masu, M. Brain Res. Dev. Brain Res. (2005) [Pubmed]
  9. HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1. Uchimura, K., Morimoto-Tomita, M., Bistrup, A., Li, J., Lyon, M., Gallagher, J., Werb, Z., Rosen, S.D. BMC Biochem. (2006) [Pubmed]
 
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