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Gene Review

SULF1  -  sulfatase 1

Homo sapiens

Synonyms: Extracellular sulfatase Sulf-1, HSULF-1, KIAA1077, SULF-1, hSulf-1
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Disease relevance of SULF1


Psychiatry related information on SULF1

  • Besides these disorders, deficiencies of arylsulfatases A, B, C, and other sulfatases have been shown in a distinct condition called "multiple sulfatase deficiency." All of these disorders are fatal and are characterized by marked demyelination and severe mental retardation [5].

High impact information on SULF1


Chemical compound and disease context of SULF1


Biological context of SULF1


Anatomical context of SULF1


Associations of SULF1 with chemical compounds


Regulatory relationships of SULF1


Other interactions of SULF1


Analytical, diagnostic and therapeutic context of SULF1


  1. HSulf-1 modulates HGF-mediated tumor cell invasion and signaling in head and neck squamous carcinoma. Lai, J.P., Chien, J., Strome, S.E., Staub, J., Montoya, D.P., Greene, E.L., Smith, D.I., Roberts, L.R., Shridhar, V. Oncogene (2004) [Pubmed]
  2. HSulf-1 inhibits angiogenesis and tumorigenesis in vivo. Narita, K., Staub, J., Chien, J., Meyer, K., Bauer, M., Friedl, A., Ramakrishnan, S., Shridhar, V. Cancer Res. (2006) [Pubmed]
  3. Enhanced levels of Hsulf-1 interfere with heparin-binding growth factor signaling in pancreatic cancer. Li, J., Kleeff, J., Abiatari, I., Kayed, H., Giese, N.A., Felix, K., Giese, T., Büchler, M.W., Friess, H. Mol. Cancer (2005) [Pubmed]
  4. A cluster of sulfatase genes on Xp22.3: mutations in chondrodysplasia punctata (CDPX) and implications for warfarin embryopathy. Franco, B., Meroni, G., Parenti, G., Levilliers, J., Bernard, L., Gebbia, M., Cox, L., Maroteaux, P., Sheffield, L., Rappold, G.A. Cell (1995) [Pubmed]
  5. Biochemical aspects of globoid and metachromatic leukodystrophies. Farooqui, A.A., Horrocks, L.A. Neurochemical pathology. (1984) [Pubmed]
  6. Molecular basis for multiple sulfatase deficiency and mechanism for formylglycine generation of the human formylglycine-generating enzyme. Dierks, T., Dickmanns, A., Preusser-Kunze, A., Schmidt, B., Mariappan, M., von Figura, K., Ficner, R., Rudolph, M.G. Cell (2005) [Pubmed]
  7. Mucopolysaccharidosis type IVA. N-acetylgalactosamine-6-sulfate sulfatase exonic point mutations in classical Morquio and mild cases. Fukuda, S., Tomatsu, S., Masue, M., Sukegawa, K., Iwata, H., Ogawa, T., Nakashima, Y., Hori, T., Yamagishi, A., Hanyu, Y. J. Clin. Invest. (1992) [Pubmed]
  8. Enzyme replacement therapy by fibroblast transplantation: long-term biochemical study in three cases of Hunter's syndrome. Dean, M.F., Stevens, R.L., Muir, H., Benson, P.F., Button, L.R., Anderson, R.L., Boylston, A., Mowbray, J. J. Clin. Invest. (1979) [Pubmed]
  9. Concentrations of estrone, estradiol, and estrone sulfate and evaluation of sulfatase and aromatase activities in pre- and postmenopausal breast cancer patients. Pasqualini, J.R., Chetrite, G., Blacker, C., Feinstein, M.C., Delalonde, L., Talbi, M., Maloche, C. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  10. High expression of steroid sulfatase mRNA predicts poor prognosis in patients with estrogen receptor-positive breast cancer. Miyoshi, Y., Ando, A., Hasegawa, S., Ishitobi, M., Taguchi, T., Tamaki, Y., Noguchi, S. Clin. Cancer Res. (2003) [Pubmed]
  11. In situ estrogen production via the estrone sulfatase pathway in breast tumors: relative importance versus the aromatase pathway. Santner, S.J., Feil, P.D., Santen, R.J. J. Clin. Endocrinol. Metab. (1984) [Pubmed]
  12. Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor. Stanway, S.J., Purohit, A., Woo, L.W., Sufi, S., Vigushin, D., Ward, R., Wilson, R.H., Stanczyk, F.Z., Dobbs, N., Kulinskaya, E., Elliott, M., Potter, B.V., Reed, M.J., Coombes, R.C. Clin. Cancer Res. (2006) [Pubmed]
  13. The hydrolysis of estrone sulfate and dehydroepiandrosterone sulfate by MCF-7 human breast cancer cells. MacIndoe, J.H. Endocrinology (1988) [Pubmed]
  14. Cloning and characterization of two cDNAs encoding sulfatases in the Roman snail, Helix pomatia. Wittstock, U., Fischer, M., Svendsen, I., Halkier, B.A. IUBMB Life (2000) [Pubmed]
  15. hSulf1 Sulfatase promotes apoptosis of hepatocellular cancer cells by decreasing heparin-binding growth factor signaling. Lai, J.P., Chien, J.R., Moser, D.R., Staub, J.K., Aderca, I., Montoya, D.P., Matthews, T.A., Nagorney, D.M., Cunningham, J.M., Smith, D.I., Greene, E.L., Shridhar, V., Roberts, L.R. Gastroenterology (2004) [Pubmed]
  16. Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer. Lai, J., Chien, J., Staub, J., Avula, R., Greene, E.L., Matthews, T.A., Smith, D.I., Kaufmann, S.H., Roberts, L.R., Shridhar, V. J. Biol. Chem. (2003) [Pubmed]
  17. SULF1 inhibits tumor growth and potentiates the effects of histone deacetylase inhibitors in hepatocellular carcinoma. Lai, J.P., Yu, C., Moser, C.D., Aderca, I., Han, T., Garvey, T.D., Murphy, L.M., Garrity-Park, M.M., Shridhar, V., Adjei, A.A., Roberts, L.R. Gastroenterology (2006) [Pubmed]
  18. HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo. Dai, Y., Yang, Y., MacLeod, V., Yue, X., Rapraeger, A.C., Shriver, Z., Venkataraman, G., Sasisekharan, R., Sanderson, R.D. J. Biol. Chem. (2005) [Pubmed]
  19. Endosome-to-Golgi transport is regulated by protein kinase A type II alpha. Birkeli, K.A., Llorente, A., Torgersen, M.L., Keryer, G., Taskén, K., Sandvig, K. J. Biol. Chem. (2003) [Pubmed]
  20. Sequence determinants directing conversion of cysteine to formylglycine in eukaryotic sulfatases. Dierks, T., Lecca, M.R., Schlotterhose, P., Schmidt, B., von Figura, K. EMBO J. (1999) [Pubmed]
  21. Expression of a heparan sulfate remodeling enzyme, heparan sulfate 6-O-endosulfatase sulfatase FP2, in the rat nervous system. Nagamine, S., Koike, S., Keino-Masu, K., Masu, M. Brain Res. Dev. Brain Res. (2005) [Pubmed]
  22. Tissue-specific expression of human arylsulfatase-C isozymes and steroid sulfatase. Munroe, D.G., Chang, P.L. Am. J. Hum. Genet. (1987) [Pubmed]
  23. 2,3,7,8-Tetrachlorodibenzo-p-dioxin causes an extensive alteration of 17 beta-estradiol metabolism in MCF-7 breast tumor cells. Spink, D.C., Lincoln, D.W., Dickerman, H.W., Gierthy, J.F. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  24. Molecular and functional analysis of SUMF1 mutations in multiple sulfatase deficiency. Cosma, M.P., Pepe, S., Parenti, G., Settembre, C., Annunziata, I., Wade-Martins, R., Di Domenico, C., Di Natale, P., Mankad, A., Cox, B., Uziel, G., Mancini, G.M., Zammarchi, E., Donati, M.A., Kleijer, W.J., Filocamo, M., Carrozzo, R., Carella, M., Ballabio, A. Hum. Mutat. (2004) [Pubmed]
  25. Aromatase and sulfatase inhibitors from Lepiota americana. Kim, D.S., Jeong, H.J., Bhat, K.P., Park, S.Y., Kang, S.H., Yoo, E.H., Lee, M., Lee, H.W., Krueger, R.J., Kim, D.S. Planta Med. (2000) [Pubmed]
  26. Effect of Decapeptyl (a GnRH analogue) and of transforming growth factor-alpha (TGF-alpha), in the presence of heparin, on the sulfatase activity of human breast cancer cells. Chetrite, G., Blumberg-Tick, J., Pasqualini, J.R. J. Steroid Biochem. Mol. Biol. (1995) [Pubmed]
  27. Distinctive gene expression of prostatic stromal cells cultured from diseased versus normal tissues. Zhao, H., Ramos, C.F., Brooks, J.D., Peehl, D.M. J. Cell. Physiol. (2007) [Pubmed]
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