Disease relevance of Socs5

• In the present study, we demonstrate that overexpression of SOCS5 in T cells augments innate immunity during septic peritonitis induced by cecal ligation and puncture (CLP) [1].
• These findings provide evidence that intervention of SOCS5 expression in T cells affects innate immunity, which highlight a novel role of T cells during sepsis [1].
• Moreover, negative regulation of the Th2-mediated response by dominant-negative SOCS3 and SOCS5 reduced the incidence of allergic conjunctivitis in a mouse model [2].

High impact information on Socs5

• SOCS5 protein was preferentially expressed in committed Th1 cells and interacted with the cytoplasmic region of the IL-4Ralpha chain irrespective of receptor tyrosine phosphorylation [3].
• T cells from transgenic mice constitutively expressing SOCS5 exhibited a significant reduction of IL-4-mediated Th2 development [3].
• We show here that during Th1 differentiation a reduction in the association of Janus kinase 1 with the IL-4 receptor (IL-4R) correlated with the appearance of the suppressor of cytokine signaling-5 (SOCS5) [3].
• However, no abnormalities in the lymphocyte compartment were seen in SOCS5-deficient mice [4].
• Because SOCS5 has been implicated in Th1 differentiation, we also investigated the importance of SOCS5 in T helper cell responses [4].

Anatomical context of Socs5

• We examined antigen- and cytokine-induced proliferative responses in B and T cells in the absence of SOCS5 and found no deviations from the responses seen in wild-type cells [4].
• On the other hand, constitutive expression of SOCS5, a specific inhibitor of IL-4 signaling, results in reduced eosinophil infiltration [2].

Regulatory relationships of Socs5

• Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation [3].

Other interactions of Socs5

• No differential expression of suppressor of cytokine signaling 1 (SOCS1), SOCS3, or SOCS5 was observed in the two cell types [5].

Analytical, diagnostic and therapeutic context of Socs5

• This unconventional interaction of SOCS5 protein with the IL-4R resulted in the inhibition of IL-4-mediated signal transducer and activator of transcription-6 activation [3].

References