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Gene Review

SOCS5  -  suppressor of cytokine signaling 5

Homo sapiens

Synonyms: CIS-6, CIS6, CISH5, CISH6, Cish5, ...
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Disease relevance of SOCS5


High impact information on SOCS5

  • In contrast, constitutive expression of SOCS5, a specific inhibitor of IL-4 signaling, resulted in reduced eosinophil infiltration [2].
  • SOCS3 and SOCS5 are predominantly expressed in Th2 and Th1 cells, respectively, and they reciprocally inhibit the Th1 and Th2 differentiation processes [4].
  • Our data also suggest that SOCS5 may serve as a new therapeutic target for uveitis and other autoimmune diseases [1].
  • SOCS5 and SOCS3 are preferentially expressed in Th1 and Th2 cells, respectively, and are thought to be lineage markers for T-helper cells [1].
  • CIS6 is structurally related to other members of the CIS family and therefore could act as a negative regulator of signal transduction [5].

Biological context of SOCS5


Anatomical context of SOCS5

  • In this study, we have investigated whether SOCS3 or SOCS5 expression can serve as surrogate markers of T-cell levels in the eye [1].
  • Northern blot analysis revealed CIS6 mRNA expression in various tissues such as heart, muscle, spleen, and thymus and in all myeloma cell lines examined [5].

Other interactions of SOCS5

  • Compared to healthy volunteers, SOCS5 mRNA is significantly elevated in PBMC of uveitis patients while SOCS3 is decreased [1].


  1. SOCS5 mRNA levels in peripheral blood mononuclear cells (PBMC): a potential bio-marker for monitoring response of uveitis patients to Daclizumab therapy. Egwuagu, C.E., Yu, C.R., Li, Z., Nussenblatt, R.B. J. Autoimmun. (2005) [Pubmed]
  2. The control of allergic conjunctivitis by suppressor of cytokine signaling (SOCS)3 and SOCS5 in a murine model. Ozaki, A., Seki, Y., Fukushima, A., Kubo, M. J. Immunol. (2005) [Pubmed]
  3. Overexpression of Suppressor of Cytokine Signaling-5 in T Cells Augments Innate Immunity during Septic Peritonitis. Watanabe, H., Kubo, M., Numata, K., Takagi, K., Mizuta, H., Okada, S., Ito, T., Matsukawa, A. J. Immunol. (2006) [Pubmed]
  4. Role of endogenous inhibitors of cytokine signaling in allergic asthma. Inoue, H., Fukuyama, S., Matsumoto, K., Kubo, M., Yoshimura, A. Current medicinal chemistry (2007) [Pubmed]
  5. Cloning and expression of CIS6, chromosome assignment to 3p22 and 2p21 by in situ hybridization. Magrangeas, F., Apiou, F., Denis, S., Weidle, U., Jacques, Y., Minvielle, S. Cytogenet. Cell Genet. (2000) [Pubmed]
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