Disease relevance of SOCS5

• SOCS5 mRNA levels in peripheral blood mononuclear cells (PBMC): a potential bio-marker for monitoring response of uveitis patients to Daclizumab therapy [1].
• The control of allergic conjunctivitis by suppressor of cytokine signaling (SOCS)3 and SOCS5 in a murine model [2].
• In the present study, we demonstrate that overexpression of SOCS5 in T cells augments innate immunity during septic peritonitis induced by cecal ligation and puncture (CLP) [3].
• These findings provide evidence that intervention of SOCS5 expression in T cells affects innate immunity, which highlight a novel role of T cells during sepsis [3].

High impact information on SOCS5

• In contrast, constitutive expression of SOCS5, a specific inhibitor of IL-4 signaling, resulted in reduced eosinophil infiltration [2].
• SOCS3 and SOCS5 are predominantly expressed in Th2 and Th1 cells, respectively, and they reciprocally inhibit the Th1 and Th2 differentiation processes [4].
• Our data also suggest that SOCS5 may serve as a new therapeutic target for uveitis and other autoimmune diseases [1].
• SOCS5 and SOCS3 are preferentially expressed in Th1 and Th2 cells, respectively, and are thought to be lineage markers for T-helper cells [1].
• CIS6 is structurally related to other members of the CIS family and therefore could act as a negative regulator of signal transduction [5].

Biological context of SOCS5

• Cloning and expression of CIS6, chromosome assignment to 3p22 and 2p21 by in situ hybridization [5].

Anatomical context of SOCS5

• In this study, we have investigated whether SOCS3 or SOCS5 expression can serve as surrogate markers of T-cell levels in the eye [1].
• Northern blot analysis revealed CIS6 mRNA expression in various tissues such as heart, muscle, spleen, and thymus and in all myeloma cell lines examined [5].

Other interactions of SOCS5

• Compared to healthy volunteers, SOCS5 mRNA is significantly elevated in PBMC of uveitis patients while SOCS3 is decreased [1].

References