Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Tacstd2 - tumor-associated calcium signal transducer 2

Mus musculus

Synonyms: C80403, Cell surface glycoprotein Trop-2, EGP-1, GA733-1, Ly97, ...

Kirman, I. et al., Kirman, I. et al., Staib, L. et al., Maruyama, H. et al., El Sewedy, T. et al.

Kirman, Maydelman, Asi, Whelan, Kirman, Poltoratskaia, Herlyn, Whelan,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tacstd2

Following 18 years of single-epitope targeting of the GA733 antigen, immunization of patients against multiple epitopes of the antigen frequently induces an immune response in the absence of significant toxicity, despite relatively widespread expression of this antigen on normal epithelial cells [1].
Ab2-immunized mice showed antigen-specific delayed-type hypersensitivity (DTH) reaction, and cultured splenocytes from the immune mice demonstrated specific proliferation and cytokine (interferon-gamma and interleukin-4) secretion upon stimulation with GA733 antigen [2].
Our goal was to study the effect of surgical intervention on the development of the immune response to epithelial cell adhesion molecule (EpCAM [GA-733]), a tumor-associated protein used for vaccination in colon cancer [3].

High impact information on Tacstd2

Cloning of the murine TROP2 gene: conservation of a PIP2-binding sequence in the cytoplasmic domain of TROP-2 [4].
Effect of surgical trauma on epithelial cell adhesion molecule (GA-733) vaccine-induced tumor resistance [3].
Open surgery leads to a decreased antibody response to the GA-733 tumor vaccine [3].
METHODS: Recombinant GA-733 and monophosphoryl-lipid A (MPLA) were incorporated into biodegradable beads and implanted in the following groups of mice: control, insufflation, and laparotomy [3].

Analytical, diagnostic and therapeutic context of Tacstd2

RESULTS: Tumors were significantly (p < 0.05) smaller in both the insufflation and open groups that received combined GA733 and IL-12 than in their respective control subjects [5].
BACKGROUND: We have previously shown that preoperative vaccination with the GA733 protein does not inhibit tumor growth in mice undergoing open surgery or carbon dioxide insufflation [5].
After 5 weeks, the mice were sacrificed, their tumors measured, GA733-specific antibodies determined by enzyme-linked immunoassay, and GA-733-specific cytotoxicity tested by flow cytometry using labeled C26-GA733 cells [5].

References

Immunogenicity of recombinant GA733-2E antigen (CO17-1A, EGP, KS1-4, KSA, Ep-CAM) in gastro-intestinal carcinoma patients. Staib, L., Birebent, B., Somasundaram, R., Purev, E., Braumüller, H., Leeser, C., Küttner, N., Li, W., Zhu, D., Diao, J., Wunner, W., Speicher, D., Beger, H.G., Song, H., Herlyn, D. Int. J. Cancer (2001) [Pubmed]
Monoclonal anti-idiotypic antibody functionally mimics the human gastrointestinal carcinoma epitope GA733. Maruyama, H., Benden, A., Li, W., Zaloudik, J., Koido, T., Taupin, J.L., Acres, B., Somasundaram, R., Prewett, M., Herlyn, D. Int. J. Cancer (1996) [Pubmed]
Effect of surgical trauma on epithelial cell adhesion molecule (GA-733) vaccine-induced tumor resistance. Kirman, I., Maydelman, A., Asi, Z., Whelan, R.L. Surgical endoscopy. (2003) [Pubmed]
Cloning of the murine TROP2 gene: conservation of a PIP2-binding sequence in the cytoplasmic domain of TROP-2. El Sewedy, T., Fornaro, M., Alberti, S. Int. J. Cancer (1998) [Pubmed]
Addition of interleukin-12 to GA733 tumor protein vaccine leads to development of tumor protective immunity despite surgical stress. Kirman, I., Poltoratskaia, N., Herlyn, D., Whelan, R.L. Surgical endoscopy. (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

TACSTD2	Bos taurus
TACSTD2	Canis lupus familiaris
TACSTD2	Gallus gallus
TACSTD2	Homo sapiens
LOC716334	Macaca mulatta
TACSTD2	Pan troglodytes
Tacstd2	Rattus norvegicus

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.