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Gene Review

Tacstd2  -  tumor-associated calcium signal transducer 2

Mus musculus

Synonyms: C80403, Cell surface glycoprotein Trop-2, EGP-1, GA733-1, Ly97, ...
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Disease relevance of Tacstd2

  • Following 18 years of single-epitope targeting of the GA733 antigen, immunization of patients against multiple epitopes of the antigen frequently induces an immune response in the absence of significant toxicity, despite relatively widespread expression of this antigen on normal epithelial cells [1].
  • Ab2-immunized mice showed antigen-specific delayed-type hypersensitivity (DTH) reaction, and cultured splenocytes from the immune mice demonstrated specific proliferation and cytokine (interferon-gamma and interleukin-4) secretion upon stimulation with GA733 antigen [2].
  • Our goal was to study the effect of surgical intervention on the development of the immune response to epithelial cell adhesion molecule (EpCAM [GA-733]), a tumor-associated protein used for vaccination in colon cancer [3].

High impact information on Tacstd2


Analytical, diagnostic and therapeutic context of Tacstd2

  • RESULTS: Tumors were significantly (p < 0.05) smaller in both the insufflation and open groups that received combined GA733 and IL-12 than in their respective control subjects [5].
  • BACKGROUND: We have previously shown that preoperative vaccination with the GA733 protein does not inhibit tumor growth in mice undergoing open surgery or carbon dioxide insufflation [5].
  • After 5 weeks, the mice were sacrificed, their tumors measured, GA733-specific antibodies determined by enzyme-linked immunoassay, and GA-733-specific cytotoxicity tested by flow cytometry using labeled C26-GA733 cells [5].


  1. Immunogenicity of recombinant GA733-2E antigen (CO17-1A, EGP, KS1-4, KSA, Ep-CAM) in gastro-intestinal carcinoma patients. Staib, L., Birebent, B., Somasundaram, R., Purev, E., Braumüller, H., Leeser, C., Küttner, N., Li, W., Zhu, D., Diao, J., Wunner, W., Speicher, D., Beger, H.G., Song, H., Herlyn, D. Int. J. Cancer (2001) [Pubmed]
  2. Monoclonal anti-idiotypic antibody functionally mimics the human gastrointestinal carcinoma epitope GA733. Maruyama, H., Benden, A., Li, W., Zaloudik, J., Koido, T., Taupin, J.L., Acres, B., Somasundaram, R., Prewett, M., Herlyn, D. Int. J. Cancer (1996) [Pubmed]
  3. Effect of surgical trauma on epithelial cell adhesion molecule (GA-733) vaccine-induced tumor resistance. Kirman, I., Maydelman, A., Asi, Z., Whelan, R.L. Surgical endoscopy. (2003) [Pubmed]
  4. Cloning of the murine TROP2 gene: conservation of a PIP2-binding sequence in the cytoplasmic domain of TROP-2. El Sewedy, T., Fornaro, M., Alberti, S. Int. J. Cancer (1998) [Pubmed]
  5. Addition of interleukin-12 to GA733 tumor protein vaccine leads to development of tumor protective immunity despite surgical stress. Kirman, I., Poltoratskaia, N., Herlyn, D., Whelan, R.L. Surgical endoscopy. (2003) [Pubmed]
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