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Chemical Compound Review

Compound 504     [(2R,3R,4R,5R,6R)-6- [[(3R,4R,5R,6S)-3,6...

Synonyms: TLC 3, LS-186831, LS-187494, LA 15PH, AC1L45OX, ...
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Disease relevance of Monophosphoryl lipid A


High impact information on Monophosphoryl lipid A


Chemical compound and disease context of Monophosphoryl lipid A


Biological context of Monophosphoryl lipid A


Anatomical context of Monophosphoryl lipid A


Associations of Monophosphoryl lipid A with other chemical compounds


Gene context of Monophosphoryl lipid A


Analytical, diagnostic and therapeutic context of Monophosphoryl lipid A


  1. Lipid IVA inhibits synthesis and release of tumor necrosis factor induced by lipopolysaccharide in human whole blood ex vivo. Kovach, N.L., Yee, E., Munford, R.S., Raetz, C.R., Harlan, J.M. J. Exp. Med. (1990) [Pubmed]
  2. Effect of cell wall skeleton and monophosphoryl lipid A adjuvant on the immunogenicity of a murine B16 melanoma vaccine. Johnston, D., Bystryn, J.C. J. Natl. Cancer Inst. (1991) [Pubmed]
  3. Liposomal malaria vaccine in humans: a safe and potent adjuvant strategy. Fries, L.F., Gordon, D.M., Richards, R.L., Egan, J.E., Hollingdale, M.R., Gross, M., Silverman, C., Alving, C.R. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  4. Monophosphoryl lipid A and QS21 increase CD8 T lymphocyte cytotoxicity to herpes simplex virus-2 infected cell proteins 4 and 27 through IFN-gamma and IL-12 production. Mikloska, Z., Rückholdt, M., Ghadiminejad, I., Dunckley, H., Denis, M., Cunningham, A.L. J. Immunol. (2000) [Pubmed]
  5. Adjuvant-dependent immune response to malarial transmission-blocking vaccine candidate antigens. Rawlings, D.J., Kaslow, D.C. J. Exp. Med. (1992) [Pubmed]
  6. A potent adjuvant monophosphoryl lipid A triggers various immune responses, but not secretion of IL-1beta or activation of caspase-1. Okemoto, K., Kawasaki, K., Hanada, K., Miura, M., Nishijima, M. J. Immunol. (2006) [Pubmed]
  7. Mucosal Administration of Ag85B-ESAT-6 Protects against Infection with Mycobacterium tuberculosis and Boosts Prior Bacillus Calmette-Guerin Immunity. Dietrich, J., Andersen, C., Rappuoli, R., Doherty, T.M., Jensen, C.G., Andersen, P. J. Immunol. (2006) [Pubmed]
  8. Monophosphoryl lipid A activates both human dendritic cells and T cells. Ismaili, J., Rennesson, J., Aksoy, E., Vekemans, J., Vincart, B., Amraoui, Z., Van Laethem, F., Goldman, M., Dubois, P.M. J. Immunol. (2002) [Pubmed]
  9. Structure of the monophosphoryl lipid A moiety obtained from the lipopolysaccharide of Chlamydia trachomatis. Qureshi, N., Kaltashov, I., Walker, K., Doroshenko, V., Cotter, R.J., Takayama, K., Sievert, T.R., Rice, P.A., Lin, J.S., Golenbock, D.T. J. Biol. Chem. (1997) [Pubmed]
  10. Purification and structural determination of nontoxic lipid A obtained from the lipopolysaccharide of Salmonella typhimurium. Qureshi, N., Takayama, K., Ribi, E. J. Biol. Chem. (1982) [Pubmed]
  11. Expression of Neisseria meningitidis class 1 porin as a fusion protein in Escherichia coli: the influence of liposomes and adjuvants on the production of a bactericidal immune response. Ward, S.J., Scopes, D., Christodoulides, M., Clarke, I.N., Heckels, J.E. Microb. Pathog. (1996) [Pubmed]
  12. Radioprotective properties of detoxified lipid A from Salmonella minnesota R595. Snyder, S.L., Walden, T.L., Patchen, M.L., MacVittie, T.J., Fuchs, P. Radiat. Res. (1986) [Pubmed]
  13. Increased immunogenicity of HIV envelope subunit complexed with alpha2-macroglobulin when combined with monophosphoryl lipid A and GM-CSF. Liao, H.X., Cianciolo, G.J., Staats, H.F., Scearce, R.M., Lapple, D.M., Stauffer, S.H., Thomasch, J.R., Pizzo, S.V., Montefiori, D.C., Hagen, M., Eldridge, J., Haynes, B.F. Vaccine (2002) [Pubmed]
  14. Bacterial endotoxin selectively prevents the expression of scavenger-receptor activity on human monocyte-macrophages. Van Lenten, B.J., Fogelman, A.M., Seager, J., Ribi, E., Haberland, M.E., Edwards, P.A. J. Immunol. (1985) [Pubmed]
  15. Endotoxic lipid A interaction with human platelets. Structure-function analysis of lipid A homologs obtained from Salmonella minnesota Re595 lipopolysaccharide. Grabarek, J., Her, G.R., Reinhold, V.N., Hawiger, J. J. Biol. Chem. (1990) [Pubmed]
  16. Regulation of antibody specificity to Plasmodium falciparum merozoite surface protein-1 by adjuvant and MHC haplotype. Chang, S.P., Nikaido, C.M., Hashimoto, A.C., Hashiro, C.Q., Yokota, B.T., Hui, G.S. J. Immunol. (1994) [Pubmed]
  17. Monophosphoryl lipid A stimulated up-regulation of reactive oxygen intermediates in human monocytes in vitro. Saha, D.C., Barua, R.S., Astiz, M.E., Rackow, E.C., Eales-Reynolds, L.J. J. Leukoc. Biol. (2001) [Pubmed]
  18. Pulmonary and hepatic gene expression following cecal ligation and puncture: monophosphoryl lipid A prophylaxis attenuates sepsis-induced cytokine and chemokine expression and neutrophil infiltration. Salkowski, C.A., Detore, G., Franks, A., Falk, M.C., Vogel, S.N. Infect. Immun. (1998) [Pubmed]
  19. Dissociation of lipopolysaccharide (LPS)-inducible gene expression in murine macrophages pretreated with smooth LPS versus monophosphoryl lipid A. Henricson, B.E., Manthey, C.L., Perera, P.Y., Hamilton, T.A., Vogel, S.N. Infect. Immun. (1993) [Pubmed]
  20. Differential sensitivity of CD8+ suppressor and cytotoxic T lymphocyte activity to bacterial monophosphoryl lipid A. Esquivel, F., Taylor, C.E., Baker, P.J. Infect. Immun. (1991) [Pubmed]
  21. Activation of macrophages from aging mice by detoxified lipid A. Chen, Y.F., Solem, L., Johnson, A.G. J. Leukoc. Biol. (1991) [Pubmed]
  22. Influence of adjuvants on the antibody specificity to the Plasmodium falciparum major merozoite surface protein, gp195. Hui, G.S., Chang, S.P., Gibson, H., Hashimoto, A., Hashiro, C., Barr, P.J., Kotani, S. J. Immunol. (1991) [Pubmed]
  23. Evaluation of monophosphoryl lipid A (MPL) as an adjuvant. Enhancement of the serum antibody response in mice to polysaccharide-protein conjugates by concurrent injection with MPL. Schneerson, R., Fattom, A., Szu, S.C., Bryla, D., Ulrich, J.T., Rudbach, J.A., Schiffman, G., Robbins, J.B. J. Immunol. (1991) [Pubmed]
  24. Induction of experimental autoimmune sialoadenitis by immunization of PL/J mice with carbonic anhydrase II. Nishimori, I., Bratanova, T., Toshkov, I., Caffrey, T., Mogaki, M., Shibata, Y., Hollingsworth, M.A. J. Immunol. (1995) [Pubmed]
  25. Interaction of anti-cholesterol antibodies with human lipoproteins. Dijkstra, J., Swartz, G.M., Raney, J.J., Aniagolu, J., Toro, L., Nacy, C.A., Green, S.J. J. Immunol. (1996) [Pubmed]
  26. Immunization with the recombinant PorB outer membrane protein induces a bactericidal immune response against Neisseria meningitidis. Wright, J.C., Williams, J.N., Christodoulides, M., Heckels, J.E. Infect. Immun. (2002) [Pubmed]
  27. Lipopolysaccharide and monophosphoryl lipid A differentially regulate interleukin-12, gamma interferon, and interleukin-10 mRNA production in murine macrophages. Salkowski, C.A., Detore, G.R., Vogel, S.N. Infect. Immun. (1997) [Pubmed]
  28. Pretreatment of normal humans with monophosphoryl lipid A induces tolerance to endotoxin: a prospective, double-blind, randomized, controlled trial. Astiz, M.E., Rackow, E.C., Still, J.G., Howell, S.T., Cato, A., Von Eschen, K.B., Ulrich, J.T., Rudbach, J.A., McMahon, G., Vargas, R. Crit. Care Med. (1995) [Pubmed]
  29. Biodegradable nanoparticle mediated antigen delivery to human cord blood derived dendritic cells for induction of primary T cell responses. Diwan, M., Elamanchili, P., Lane, H., Gainer, A., Samuel, J. Journal of drug targeting. (2003) [Pubmed]
  30. Stimulation of splenocytes in C3H/HeJ mice with Porphyromonas gingivalis lipid A in comparison with enterobacterial lipid A. Ogawa, T., Shimauchi, H., Uchida, H., Mori, Y. Immunobiology (1996) [Pubmed]
  31. Regulation of macrophage TNF alpha, IL-1 beta, and Ia (I-A alpha) mRNA expression during peritonitis is site dependent. McMasters, K.M., Cheadle, W.G. J. Surg. Res. (1993) [Pubmed]
  32. The serologic response to Meth A sarcoma vaccines after cyclophosphamide treatment is additionally increased by various adjuvants. Livingston, P.O., Jones, M., Deleo, A.B., Oettgen, H.F., Old, L.J. J. Immunol. (1985) [Pubmed]
  33. Mechanisms of immunotherapy. Till, S.J., Francis, J.N., Nouri-Aria, K., Durham, S.R. J. Allergy Clin. Immunol. (2004) [Pubmed]
  34. Myocardial ischemia/reperfusion protection using monophosphoryl lipid A is abrogated by the ATP-sensitive potassium channel blocker, glibenclamide. Elliott, G.T., Comerford, M.L., Smith, J.R., Zhao, L. Cardiovasc. Res. (1996) [Pubmed]
  35. Safety, immunogenicity, and efficacy of Plasmodium falciparum repeatless circumsporozoite protein vaccine encapsulated in liposomes. Heppner, D.G., Gordon, D.M., Gross, M., Wellde, B., Leitner, W., Krzych, U., Schneider, I., Wirtz, R.A., Richards, R.L., Trofa, A., Hall, T., Sadoff, J.C., Boerger, P., Alving, C.R., Sylvester, D.R., Porter, T.G., Ballou, W.R. J. Infect. Dis. (1996) [Pubmed]
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