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Gene Review

PNPLA2  -  patatin-like phospholipase domain...

Homo sapiens

Synonyms: 1110001C14Rik, ATGL, Adipose triglyceride lipase, Calcium-independent phospholipase A2, Desnutrin, ...
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Disease relevance of PNPLA2


High impact information on PNPLA2


Biological context of PNPLA2


Anatomical context of PNPLA2

  • HSL and ATGL cDNAs were transfected into Cos-7 cells and the relative tri- and diglyceride hydrolase activities were measured [1].
  • Adiponutrin and a related protein, adipocyte triglyceride lipase (ATGL; also known as Desnutrin), were recently described as adipocyte-specific proteins with lipid hydrolase activity [3].

Associations of PNPLA2 with chemical compounds

  • Recently, PEDF-R (TTS-2.2/independent phospholipase A(2) (PLA(2))zeta and mouse desnutrin/ATGL) has been described in adipose cells as a member of the new calcium-independent PLA(2)/nutrin/patatin-like phospholipase domain-containing 2 (PNPLA2) family that possesses triglyceride lipase and acylglycerol transacylase activities [4].
  • Both mRNA and protein levels of ATGL and HSL were reduced in insulin-resistant compared with insulin-sensitive subjects (P < 0.05) [5].

Other interactions of PNPLA2


  1. Human adipose triglyceride lipase (PNPLA2) is not regulated by obesity and exhibits low in vitro triglyceride hydrolase activity. Mairal, A., Langin, D., Arner, P., Hoffstedt, J. Diabetologia (2006) [Pubmed]
  2. The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy. Fischer, J., Lef??vre, C., Morava, E., Mussini, J.M., Lafor??t, P., Negre-Salvayre, A., Lathrop, M., Salvayre, R. Nat. Genet. (2007) [Pubmed]
  3. Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family members. Lake, A.C., Sun, Y., Li, J.L., Kim, J.E., Johnson, J.W., Li, D., Revett, T., Shih, H.H., Liu, W., Paulsen, J.E., Gimeno, R.E. J. Lipid Res. (2005) [Pubmed]
  4. Identification of a Lipase-linked Cell Membrane Receptor for Pigment Epithelium-derived Factor. Notari, L., Baladron, V., Aroca-Aguilar, J.D., Balko, N., Heredia, R., Meyer, C., Notario, P.M., Saravanamuthu, S., Nueda, M.L., Sanchez-Sanchez, F., Escribano, J., Laborda, J., Becerra, S.P. J. Biol. Chem. (2006) [Pubmed]
  5. Adipose triglyceride lipase and hormone-sensitive lipase protein expression is decreased in the obese insulin-resistant state. Jocken, J.W., Langin, D., Smit, E., Saris, W.H., Valle, C., Hul, G.B., Holm, C., Arner, P., Blaak, E.E. J. Clin. Endocrinol. Metab. (2007) [Pubmed]
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