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Gene Review

RAB25  -  RAB25, member RAS oncogene family

Homo sapiens

Synonyms: CATX-8, CATX8, RAB11C, Ras-related protein Rab-25
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Disease relevance of RAB25

  • RAB25 mRNA levels were selectively increased in stage III and IV serous epithelial ovarian cancers compared to other genes within the amplified region, implicating RAB25 as a driving event in the development of the amplicon [1].
  • We have recently shown that RAB25, located at chromosome 1q22, is amplified at the DNA level and overexpressed at the RNA level in ovarian and breast cancer [2].

High impact information on RAB25

  • High-density array comparative genomic hybridization (CGH) showed amplification of chromosome 1q22 centered on the RAB25 small GTPase, which is implicated in apical vesicle trafficking, in approximately half of ovarian and breast cancers [1].
  • Forced expression of RAB25 markedly increased anchorage-dependent and anchorage-independent cell proliferation, prevented apoptosis and anoikis, including that induced by chemotherapy, and increased aggressiveness of cancer cells in vivo [1].
  • Overall, these studies implicate RAB25, and thus the RAB family of small G proteins, in aggressiveness of epithelial cancers [1].
  • A major 1.2 kilobase Rab25 message was detected throughout the gastrointestinal mucosa and in lung and kidney tissue [3].
  • Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung [3].

Biological context of RAB25


Associations of RAB25 with chemical compounds


Analytical, diagnostic and therapeutic context of RAB25

  • Increased DNA copy number or RNA level of RAB25 was associated with markedly decreased disease-free survival or overall survival in ovarian and breast cancers, respectively [1].


  1. The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers. Cheng, K.W., Lahad, J.P., Kuo, W.L., Lapuk, A., Yamada, K., Auersperg, N., Liu, J., Smith-McCune, K., Lu, K.H., Fishman, D., Gray, J.W., Mills, G.B. Nat. Med. (2004) [Pubmed]
  2. Emerging role of RAB GTPases in cancer and human disease. Cheng, K.W., Lahad, J.P., Gray, J.W., Mills, G.B. Cancer Res. (2005) [Pubmed]
  3. Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung. Goldenring, J.R., Shen, K.R., Vaughan, H.D., Modlin, I.M. J. Biol. Chem. (1993) [Pubmed]
  4. Interactions of myosin vb with rab11 family members and cargoes traversing the plasma membrane recycling system. Lapierre, L.A., Goldenring, J.R. Meth. Enzymol. (2005) [Pubmed]
  5. The crystal structure of the small GTPase Rab11b reveals critical differences relative to the Rab11a isoform. Scapin, S.M., Carneiro, F.R., Alves, A.C., Medrano, F.J., Guimarães, B.G., Zanchin, N.I. J. Struct. Biol. (2006) [Pubmed]
  6. Increased immunoreactivity for Rab11, a small GTP-binding protein, in low-grade dysplastic Barrett's epithelia. Ray, G.S., Lee, J.R., Nwokeji, K., Mills, L.R., Goldenring, J.R. Lab. Invest. (1997) [Pubmed]
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