Disease relevance of S100A14

• By analyzing a human lung cancer cell line subtraction cDNA library, we have identified and characterized a new member of the human S100 family that we named S100A14 (GenBank acc. no. NM_020672) [1].
• Although its biological function is unclear, the association of the 11.2 kDa S100A15 with psoriasis suggests that it contributes to the pathogenesis of the disease and could provide a molecular target for therapy [2].

High impact information on S100A14

• Mapping of D4S98/S114/S113 confines the Huntington's defect to a reduced physical region at the telomere of chromosome 4 [3].
• Molecular cloning and characterization of the human S100A14 gene encoding a novel member of the S100 family [1].
• We examined the intracellular distribution of the epitope-tagged S100A14 protein in two human lung carcinoma cell lines and one immortalized monkey cell line [1].
• The deduced amino acid sequence of the human S100A14 and its mouse homolog (identified as GenBank entry) contains two EF-hand Ca2+-binding domains, a myristoylation motif, a glycosylation site, and several potential protein kinase phosphorylation sites [1].
• We also provide evidence for heterogenic expression of S100A14 in tumors, demonstrating its overexpression in ovary, breast, and uterus tumors and underexpression in kidney, rectum, and colon tumors, a pattern suggesting distinct regulation with potentially important functions in malignant transformation [1].

Biological context of S100A14

• Human S100A15 is a novel member of the S100 family of EF-hand calcium-binding proteins and was recently identified in psoriasis, where it is significantly upregulated in lesional skin [2].

Associations of S100A14 with chemical compounds

• The baseline HR was higher with sevoflurane (S 114 +/- 13 bpm, H 101 +/- 15 bpm, P = 0.002) [4].
• The pentanol-enzyme interaction yielded the following: delta H 46 Kcal mol-1 and delta S 114 cal mol-1 deg-1 [5].

Analytical, diagnostic and therapeutic context of S100A14

• Purification, crystallization and preliminary X-ray diffraction of human S100A15 [2].

References