Disease relevance of APM1

• Prospective longitudinal studies revealed that the plasma levels of adiponectin declined at an early phase of obesity and remained decreased after the development of type 2 diabetes [1].

High impact information on APM1

• Longitudinally, the plasma adiponectin decreased in parallel to the progression of insulin resistance [1].
• Hyperinsulinemic-euglycemic clamp studies revealed that the obese monkeys with lower plasma adiponectin showed significantly lower insulin-stimulated peripheral glucose uptake (M rate) [1].
• Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys [1].
• No clear association was found between the plasma levels of adiponectin and its mRNA levels in adipose tissue [1].
• Is microvascular flow rate related to ghrelin, leptin and adiponectin levels [2]?

Anatomical context of APM1

• Adiponectin, apart from its insulin-sensitizing action, appears to modulate inflammation by inhibiting monocyte adhesion to endothelial cells [2].

Analytical, diagnostic and therapeutic context of APM1

• Using univariate analysis, it appears that increased perfusion is significantly correlated with adiponectin, followed by leptin [2].

References