Disease relevance of ALPK3

• CONCLUSION: Concentrations of organic solvents not exceeding their MAK values can cause subclinical rhinitis [1].

High impact information on ALPK3

• EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome [2].
• Furthermore, MAK was recruited to the cell membrane by Frizzled 3, formed a complex with Dishevelled and phosphorylated Dsh in vitro [3].
• Confirming the inhibitory role for this kinase in Wnt/beta-catenin signaling, the midbrain patterning defects in embryos depleted of MAK were rescued by the simultaneous depletion of beta-catenin [3].
• Outer arm dynein was purified from sperm flagella of a sea anemone, Anthopleura midori, and its biochemical and biophysical properties were characterized [4].
• From the findings obtained in plasma and urine and from a toxicokinetic analysis of these data, it is highly unlikely that workplace EG exposure according to the German exposure limit (MAK-value 10 ppm EG, 8 h) could lead to adverse effects from the metabolically formed GA and OA [5].

Biological context of ALPK3

• The intrinsic stochastic effects in chemical reactions, and particularly in biochemical networks, may result in behaviors significantly different from those predicted by deterministic mass action kinetics (MAK) [6].
• The full set of scenarios shows for which historical situations the workplace concentrations were near the MAK value and that the transition to newer dry-cleaning machines reduced the occupational exposure by more than one order of magnitude [7].
• The authors have been involved in routine well-child medical examinations at 18 months of age, at the Midori Public Health Center in Nagoya. A statistical survey of diagnoses was made from April 1979 to March 1984 for the purpose of conducting an epidemiological study of autism [8].

References