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Gene Review

FZD3  -  frizzled class receptor 3

Homo sapiens

Synonyms: Frizzled-3, Fz-3, hFz3
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Disease relevance of FZD3


Psychiatry related information on FZD3


High impact information on FZD3


Biological context of FZD3


Anatomical context of FZD3

  • 0-kb FZD3 mRNA was the major transcript in fetal brain and adult cerebellum, while the 1.8-kb FZD3 mRNA was the major transcript in adult pancreas, and many cancer cell lines examined [8].
  • Of the frizzled proteins, frizzled-3 (FZD3) is required for formation of the neural crest and for development of major fiber tracts in the CNS [7].
  • We now report that Frizzled-3 expression in skin is restricted to the epidermis and to the developing hair follicle [1].
  • In 17 d embryos and 1 d old newborn mice Frizzled-3 expression is limited to suprabasal keratinocytes and is not seen in pelage follicles until 3 d postpartum [1].
  • In the inner ear, Fz3 and Fz6 proteins are localized to the lateral faces of sensory and supporting cells in all sensory epithelia in a pattern that correlates with the axis of planar polarity [11].

Associations of FZD3 with chemical compounds

  • Human Frizzled-3 (FZD3) gene, encoding seven-transmembrane receptor with the N-terminal cysteine-rich domain, has been cloned and characterized [8].

Other interactions of FZD3

  • The minimum vertical force (Fz2), the second vertical peak force (Fz3), and the duration of stride and stance were significantly higher in groups 2 and 3 [12].

Analytical, diagnostic and therapeutic context of FZD3


  1. Characterization of mouse Frizzled-3 expression in hair follicle development and identification of the human homolog in keratinocytes. Hung, B.S., Wang, X.Q., Cam, G.R., Rothnagel, J.A. J. Invest. Dermatol. (2001) [Pubmed]
  2. Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders. Hashimoto, R., Suzuki, T., Iwata, N., Yamanouchi, Y., Kitajima, T., Kosuga, A., Tatsumi, M., Ozaki, N., Kamijima, K., Kunugi, H. Journal of neural transmission (Vienna, Austria : 1996) (2005) [Pubmed]
  3. Metastasis-associated kinase modulates Wnt signaling to regulate brain patterning and morphogenesis. Kibardin, A., Ossipova, O., Sokol, S.Y. Development (2006) [Pubmed]
  4. Phosphorylation of frizzled-3. Yanfeng, W.A., Tan, C., Fagan, R.J., Klein, P.S. J. Biol. Chem. (2006) [Pubmed]
  5. Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10. Cheng, J., Wang, H., Guggino, W.B. J. Biol. Chem. (2005) [Pubmed]
  6. Genetic and expression analyses of FZD3 in schizophrenia. Ide, M., Muratake, T., Yamada, K., Iwayama-Shigeno, Y., Iwamoto, K., Takao, H., Toyota, T., Kaneko, N., Minabe, Y., Nakamura, K., Kato, T., Mori, N., Asada, T., Someya, T., Yoshikawa, T. Biol. Psychiatry (2004) [Pubmed]
  7. The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia. Katsu, T., Ujike, H., Nakano, T., Tanaka, Y., Nomura, A., Nakata, K., Takaki, M., Sakai, A., Uchida, N., Imamura, T., Kuroda, S. Neurosci. Lett. (2003) [Pubmed]
  8. Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21. Kirikoshi, H., Koike, J., Sagara, N., Saitoh, T., Tokuhara, M., Tanaka, K., Sekihara, H., Hirai, M., Katoh, M. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  9. Identification, gene structure, and expression of human frizzled-3 (FZD3). Sala, C.F., Formenti, E., Terstappen, G.C., Caricasole, A. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  10. Investigation of genetic association between human Frizzled homolog 3 gene (FZD3) and schizophrenia: results in a Korean population and evidence from meta-analysis. Jeong, S.H., Joo, E.J., Ahn, Y.M., Lee, K.Y., Kim, Y.S. Psychiatry research. (2006) [Pubmed]
  11. The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells. Wang, Y., Guo, N., Nathans, J. J. Neurosci. (2006) [Pubmed]
  12. Influence of speed variation and age on ground reaction forces and stride parameters of children's normal gait. Diop, M., Rahmani, A., Belli, A., Gautheron, V., Geyssant, A., Cottalorda, J. International journal of sports medicine. (2005) [Pubmed]
  13. Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population. Zhang, Y., Yu, X., Yuan, Y., Ling, Y., Ruan, Y., Si, T., Lu, T., Wu, S., Gong, X., Zhu, Z., Yang, J., Wang, F., Zhang, D. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2004) [Pubmed]
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