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Gene Review

casp8  -  caspase 8, apoptosis-related cysteine...

Danio rerio

Synonyms: SO:0000704, caspase-8, zgc:92075
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Disease relevance of casp8

  • Taken together, these findings suggest that successful virus replication occurs at the low temperature (18 degrees C) compared with the non-permissive temperature of 28 degrees C. Thus, IPNV replication is capable of activating caspase-8 and -3 and inducing host apoptosis [1].

High impact information on casp8


Anatomical context of casp8

  • Finally, the observed activation of caspase 8 in the morphants is in accord with the ability of Yaf2 to inhibit caspase 8-mediated apoptosis in cultured cells [3].


  1. Aquatic birnavirus induces apoptosis through activated caspase-8 and -3 in a zebrafish cell line. Hong, J.R., Huang, L.J., Wu, J.L. J. Fish Dis. (2005) [Pubmed]
  2. Delineation of the cell-extrinsic apoptosis pathway in the zebrafish. Eimon, P.M., Kratz, E., Varfolomeev, E., Hymowitz, S.G., Stern, H., Zha, J., Ashkenazi, A. Cell Death Differ. (2006) [Pubmed]
  3. Yaf2 Inhibits Caspase 8-mediated Apoptosis and Regulates Cell Survival during Zebrafish Embryogenesis. Stanton, S.E., McReynolds, L.J., Evans, T., Schreiber-Agus, N. J. Biol. Chem. (2006) [Pubmed]
  4. Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds. Studies using human acute lymphoblastic leukemia cells and the zebrafish model. Benyumov, A.O., Venkatachalam, T.K., Grigoriants, O.O., Vassilev, A.O., Tibbles, H.E., Downs, S., Dumezb, D., Uckun, F.M. Arzneimittel-Forschung. (2005) [Pubmed]
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