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Gene Review

CASP8  -  caspase 8, apoptosis-related cysteine...

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Disease relevance of CASP8


High impact information on CASP8

  • LPA increased phosphatidylinositol 3-kinase (PI3K)-dependent Akt activation, cellular FLICE-inhibitory protein (cFLIP) expression, and Bad phosphorylation, resulting in inhibition of caspase-8 activation and Bad translocation to mitochondria [4].
  • Moreover, in Rho0-EC we identified activation of caspase-8 as part of the mitochondrial-independent pathway of apoptosis [5].
  • We found that anti-apoptotic proteins such as cellular (c)-FLIP, which functions as a catalytically inactive form of caspase-8, and X-chromosome-linked inhibitor of apoptosis protein (IAP) as well as c-IAP, which can block downstream executioner caspases, are constitutively expressed in T. parva-transformed T cells [6].
  • Incubation of BL-3 cells with a low concentration of LKT results in the activation of caspase-3 and caspase-9 but not caspase-8 [7].
  • The P2X antagonist oATP significantly blocked caspase-8 but not caspase-9 activation in LOS-treated endothelial cells [8].

Anatomical context of CASP8


Associations of CASP8 with chemical compounds


Other interactions of CASP8

  • Given that HSV2-R1, a specific inhibitor of the caspase-8 activation pathway, efficiently suppressed apoptosis and also prevented caspase-9 activation, the overall results indicate that the BVDV NS3/NS3Delta50 induces apoptosis initiated by caspase-8 activation and subsequent cytochrome c release-dependent caspase-9 activation [16].

Analytical, diagnostic and therapeutic context of CASP8


  1. A novel family of viral death effector domain-containing molecules that inhibit both CD-95- and tumor necrosis factor receptor-1-induced apoptosis. Hu, S., Vincenz, C., Buller, M., Dixit, V.M. J. Biol. Chem. (1997) [Pubmed]
  2. A method for functional evaluation of caspase activation pathways in intact lymphoid cells using electroporation-mediated protein delivery and flow cytometric analysis. Eksioglu-Demiralp, E., Kitada, S., Carson, D., Garland, J., Andreef, M., Reed, J.C. J. Immunol. Methods (2003) [Pubmed]
  3. Tumor necrosis factor-alpha enhances Haemophilus somnus lipooligosaccharide-induced apoptosis of bovine endothelial cells. Sylte, M.J., Kuckleburg, C.J., Leite, F.P., Inzana, T.J., Czuprynski, C.J. Vet. Immunol. Immunopathol. (2006) [Pubmed]
  4. Serum bioactive lysophospholipids prevent TRAIL-induced apoptosis via PI3K/Akt-dependent cFLIP expression and Bad phosphorylation. Kang, Y.C., Kim, K.M., Lee, K.S., Namkoong, S., Lee, S.J., Han, J.A., Jeoung, D., Ha, K.S., Kwon, Y.G., Kim, Y.M. Cell Death Differ. (2004) [Pubmed]
  5. Hypoxia potentiates nitric oxide-mediated apoptosis in endothelial cells via peroxynitrite-induced activation of mitochondria-dependent and -independent pathways. Walford, G.A., Moussignac, R.L., Scribner, A.W., Loscalzo, J., Leopold, J.A. J. Biol. Chem. (2004) [Pubmed]
  6. Theileria parva-transformed T cells show enhanced resistance to Fas/Fas ligand-induced apoptosis. Küenzi, P., Schneider, P., Dobbelaere, D.A. J. Immunol. (2003) [Pubmed]
  7. Mannheimia haemolytica leukotoxin induces apoptosis of bovine lymphoblastoid cells (BL-3) via a caspase-9-dependent mitochondrial pathway. Atapattu, D.N., Czuprynski, C.J. Infect. Immun. (2005) [Pubmed]
  8. Stimulation of P2X receptors enhances lipooligosaccharide-mediated apoptosis of endothelial cells. Sylte, M.J., Kuckleburg, C.J., Inzana, T.J., Bertics, P.J., Czuprynski, C.J. J. Leukoc. Biol. (2005) [Pubmed]
  9. Involvement of glutathione as a mechanism of indirect protection against spontaneous ex vivo apoptosis associated with bovine leukemia virus. Sanchez Alcaraz, T., Kerkhofs, P., Reichert, M., Kettmann, R., Willems, L. J. Virol. (2004) [Pubmed]
  10. Effects of glucocorticoids on Fas gene expression in bovine blood neutrophils. Chang, L.C., Madsen, S.A., Toelboell, T., Weber, P.S., Burton, J.L. J. Endocrinol. (2004) [Pubmed]
  11. Involvement of caspase-10 in advanced glycation end-product-induced apoptosis of bovine retinal pericytes in culture. Lecomte, M., Denis, U., Ruggiero, D., Lagarde, M., Wiernsperger, N. Biochim. Biophys. Acta (2004) [Pubmed]
  12. Regulation of apoptosis in the atresia of dominant bovine follicles of the first follicular wave following ovulation. Valdez, K.E., Cuneo, S.P., Turzillo, A.M. Reproduction (2005) [Pubmed]
  13. Molecular mechanism of bovine trabecular meshwork cells apoptosis induced by dexamethasone and protection by pilocarpine. Gu, Y., Zeng, S., Qiu, P., Wu, Y., Peng, D., Yan, G. Yan ke xue bao = Eye science / "Yan ke xue bao" bian ji bu (2005) [Pubmed]
  14. Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets. Maedler, K., Spinas, G.A., Lehmann, R., Sergeev, P., Weber, M., Fontana, A., Kaiser, N., Donath, M.Y. Diabetes (2001) [Pubmed]
  15. Ceramide alters endothelial cell permeability by a nonapoptotic mechanism. Lindner, K., Uhlig, U., Uhlig, S. Br. J. Pharmacol. (2005) [Pubmed]
  16. The bovine viral diarrhea virus (BVDV) NS3 protein, when expressed alone in mammalian cells, induces apoptosis which correlates with caspase-8 and caspase-9 activation. St-Louis, M.C., Massie, B., Archambault, D. Vet. Res. (2005) [Pubmed]
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