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Gene Review

Casp8  -  caspase 8

Rattus norvegicus

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Disease relevance of Casp8


Psychiatry related information on Casp8


High impact information on Casp8


Chemical compound and disease context of Casp8


Biological context of Casp8


Anatomical context of Casp8


Associations of Casp8 with chemical compounds


Regulatory relationships of Casp8

  • These data suggest that C5b-9 through PI3K signaling can rescue OLG from Fas-mediated apoptosis by regulating caspase-8 processing [13].
  • Finally, we show that the caspase 8 inhibitor Ac-IETD-CHO was more effective at blocking seizure-induced cell death than the caspase 9 inhibitor Ac-LEHD-CHO [24].
  • Although caspase-8 is known to be involved in death-receptor-dependent apoptosis, measurable caspase-8 activity or even RGC death could be induced by neither tumor necrosis factor-alpha nor Fas ligand injections into unlesioned eyes [17].
  • Therefore, these results suggest that TNF-alpha-induced increase in apoptosis in ARVM results from caspase-8-dependent impairment of mitochondrial integrity [16].
  • This death was shown to be caspase dependent in primary neuronal cultures and was blocked by the selective caspase 8 inhibitor IETD [25].

Other interactions of Casp8

  • Under this condition, we found that caspase-8 processing was increased in association with Bid cleavage and markedly reduced expression of cellular FLIP long isoform protein [13].
  • In the present study, we examined the possible involvement of the caspase-8 and Fas pathway in OLG apoptosis and the role of C5b-9 in this process [13].
  • Supramaximal secretory stimulation of acini with CCK leads to a rapid redistribution and activation of caspase 8, followed by degradation of plectin that in turn precedes the F-actin breakdown [1].
  • Moreover, GCDCA-induced apoptosis was increased by ECDP, as revealed by enhanced Bax-alpha/Bcl-2 ratio (both in AHs and FHs) and the activity of caspase-8 (only in AHs) and caspase-3 [26].
  • BLM exposure had no marked effect on AM expression of TNF-R1 or caspase-8 activation, but significantly increased the expression of TNF-R2 that was accompanied by a rise in c-IAP1 and a decrease in TRAF2 [27].

Analytical, diagnostic and therapeutic context of Casp8


  1. Caspase 8-mediated cleavage of plectin precedes F-actin breakdown in acinar cells during pancreatitis. Beil, M., Leser, J., Lutz, M.P., Gukovskaya, A., Seufferlein, T., Lynch, G., Pandol, S.J., Adler, G. Am. J. Physiol. Gastrointest. Liver Physiol. (2002) [Pubmed]
  2. Anandamide-induced cell death in primary neuronal cultures: role of calpain and caspase pathways. Movsesyan, V.A., Stoica, B.A., Yakovlev, A.G., Knoblach, S.M., Lea, P.M., Cernak, I., Vink, R., Faden, A.I. Cell Death Differ. (2004) [Pubmed]
  3. Importance of FADD signaling in serum deprivation- and hypoxia-induced cardiomyocyte apoptosis. Chao, W., Shen, Y., Li, L., Rosenzweig, A. J. Biol. Chem. (2002) [Pubmed]
  4. FAS-mediated apoptosis and its relation to intrinsic pathway activation in an experimental model of retinal detachment. Zacks, D.N., Zheng, Q.D., Han, Y., Bakhru, R., Miller, J.W. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  5. Apoptosis of skeletal muscle on steroid-induced myopathy in rats. Lee, M.C., Wee, G.R., Kim, J.H. J. Nutr. (2005) [Pubmed]
  6. Beta-amyloid of Alzheimer's disease activates an apoptotic pathway via caspase-8. Reilly, C.E. J. Neurol. (2000) [Pubmed]
  7. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nakagawa, T., Zhu, H., Morishima, N., Li, E., Xu, J., Yankner, B.A., Yuan, J. Nature (2000) [Pubmed]
  8. Phosphorylation by protein kinase CK2: a signaling switch for the caspase-inhibiting protein ARC. Li, P.F., Li, J., Müller, E.C., Otto, A., Dietz, R., von Harsdorf, R. Mol. Cell (2002) [Pubmed]
  9. Caspase-8 is required for cell death induced by expanded polyglutamine repeats. Sánchez, I., Xu, C.J., Juo, P., Kakizaka, A., Blenis, J., Yuan, J. Neuron (1999) [Pubmed]
  10. Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation. Reinehr, R., Graf, D., Häussinger, D. Gastroenterology (2003) [Pubmed]
  11. Purified photoproducts of merocyanine 540 trigger cytochrome C release and caspase 8-dependent apoptosis in human leukemia and melanoma cells. Pervaiz, S., Seyed, M.A., Hirpara, J.L., Clément, M.V., Loh, K.W. Blood (1999) [Pubmed]
  12. Loss of Rb-E2F repression results in caspase-8-mediated apoptosis through inactivation of focal adhesion kinase. Lieman, J.H., Worley, L.A., Harbour, J.W. J. Biol. Chem. (2005) [Pubmed]
  13. C5b-9 terminal complex protects oligodendrocytes from apoptotic cell death by inhibiting caspase-8 processing and up-regulating FLIP. Cudrici, C., Niculescu, F., Jensen, T., Zafranskaia, E., Fosbrink, M., Rus, V., Shin, M.L., Rus, H. J. Immunol. (2006) [Pubmed]
  14. Caspase-8 activation and oxidative stress are involved in the cytotoxic effect of beta-amyloid on rat brain microvascular endothelial cells. Folin, M., Baiguera, S., Fioravanzo, L., Conconi, M.T., Grandi, C., Nussdorfer, G.G., Parnigotto, P.P. Int. J. Mol. Med. (2006) [Pubmed]
  15. Sepsis: prognostic role of apoptosis regulators in gastrointestinal cells. Messaris, E., Kekis, P., Memos, N., Chatzigianni, E., Menenakos, E., Leandros, E., Konstadoulakis, M.M. World journal of surgery (2007) [Pubmed]
  16. TNF-alpha-induced impairment of mitochondrial integrity and apoptosis mediated by caspase-8 in adult ventricular myocytes. Zhu, J., Liu, M., Kennedy, R.H., Liu, S.J. Cytokine (2006) [Pubmed]
  17. Contribution of caspase-8 to apoptosis of axotomized rat retinal ganglion cells in vivo. Weishaupt, J.H., Diem, R., Kermer, P., Krajewski, S., Reed, J.C., Bähr, M. Neurobiol. Dis. (2003) [Pubmed]
  18. Pathways leading to apoptotic neurodegeneration following trauma to the developing rat brain. Felderhoff-Mueser, U., Sifringer, M., Pesditschek, S., Kuckuck, H., Moysich, A., Bittigau, P., Ikonomidou, C. Neurobiol. Dis. (2002) [Pubmed]
  19. Roles of insulin-like growth factor II in cardiomyoblast apoptosis and in hypertensive rat heart with abdominal aorta ligation. Lee, S.D., Chu, C.H., Huang, E.J., Lu, M.C., Liu, J.Y., Liu, C.J., Hsu, H.H., Lin, J.A., Kuo, W.W., Huang, C.Y. Am. J. Physiol. Endocrinol. Metab. (2006) [Pubmed]
  20. Tetramethylpyrazine Attenuates Adriamycin-Induced Apoptotic Injury in Rat Renal Tubular Cells NRK-52E. Cheng, C.Y., Sue, Y.M., Chen, C.H., Hou, C.C., Chan, P., Chu, Y.L., Chen, T.H., Hsu, Y.H. Planta Med. (2006) [Pubmed]
  21. A(1) adenosine receptor signal and AMPK involving caspase-9/-3 activation are responsible for adenosine-induced RCR-1 astrocytoma cell death. Sai, K., Yang, D., Yamamoto, H., Fujikawa, H., Yamamoto, S., Nagata, T., Saito, M., Yamamura, T., Nishizaki, T. Neurotoxicology (2006) [Pubmed]
  22. Thioredoxin inhibits NMDA-induced neurotoxicity in the rat retina. Inomata, Y., Nakamura, H., Tanito, M., Teratani, A., Kawaji, T., Kondo, N., Yodoi, J., Tanihara, H. J. Neurochem. (2006) [Pubmed]
  23. Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity. Smith, W.W., Jiang, H., Pei, Z., Tanaka, Y., Morita, H., Sawa, A., Dawson, V.L., Dawson, T.M., Ross, C.A. Hum. Mol. Genet. (2005) [Pubmed]
  24. Activation of the caspase 8 pathway mediates seizure-induced cell death in cultured hippocampal neurons. Meller, R., Clayton, C., Torrey, D.J., Schindler, C.K., Lan, J.Q., Cameron, J.A., Chu, X.P., Xiong, Z.G., Simon, R.P., Henshall, D.C. Epilepsy Res. (2006) [Pubmed]
  25. Fas/CD95/APO-1 can function as a death receptor for neuronal cells in vitro and in vivo and is upregulated following cerebral hypoxic-ischemic injury to the developing rat brain. Felderhoff-Mueser, U., Taylor, D.L., Greenwood, K., Kozma, M., Stibenz, D., Joashi, U.C., Edwards, A.D., Mehmet, H. Brain Pathol. (2000) [Pubmed]
  26. Maternal ethanol consumption during pregnancy enhances bile acid-induced oxidative stress and apoptosis in fetal rat liver. Perez, M.J., Velasco, E., Monte, M.J., Gonzalez-Buitrago, J.M., Marin, J.J. Toxicology (2006) [Pubmed]
  27. Time-dependent apoptosis of alveolar macrophages from rats exposed to bleomycin: involvement of tnf receptor 2. Zhao, H.W., Hu, S.Y., Barger, M.W., Ma, J.K., Castranova, V., Ma, J.Y. J. Toxicol. Environ. Health Part A (2004) [Pubmed]
  28. What doesn't kill you makes you stronger: how hepatocytes survive prolonged cholestasis. Maher, J.J. Hepatology (2004) [Pubmed]
  29. Pathways of caspase-mediated apoptosis in autosomal-dominant polycystic kidney disease (ADPKD). Tao, Y., Kim, J., Stanley, M., He, Z., Faubel, S., Schrier, R.W., Edelstein, C.L. Kidney Int. (2005) [Pubmed]
  30. Different signaling pathways induce apoptosis in endothelial cells and cardiac myocytes during ischemia/reperfusion injury. Scarabelli, T.M., Stephanou, A., Pasini, E., Comini, L., Raddino, R., Knight, R.A., Latchman, D.S. Circ. Res. (2002) [Pubmed]
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