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Gene Review

RAD51C  -  RAD51 paralog C

Homo sapiens

Synonyms: BROVCA3, DNA repair protein RAD51 homolog 3, FANCO, R51H3, RAD51 homolog C, ...
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High impact information on RAD51C

  • In addition to being critical for RAD51 focus formation, RAD51C localizes to DNA damage sites [1].
  • Inhibition of RAD51C results in a decrease in cellular proliferation consistent with a role in repairing double-strand breaks (DSBs) that occur naturally [1].
  • Complex formation by the human RAD51C and XRCC3 recombination repair proteins [2].
  • Expression analysis in 12 primary tumors showed that RAD51C and S6K were consistently expressed in all cases in which they were amplified and also in some tumors without amplification [3].
  • Here, we show that, like MLH1, RAD51C localized to mouse meiotic chromosomes at pachytene/diplotene [4].

Biological context of RAD51C


Anatomical context of RAD51C

  • The RAD51C transcript is expressed in various human tissues, with highest level of expression in testis, followed by heart muscle, spleen and prostate [5].
  • Here, we confirm that the frequency of DNA double-strand break (DSB)-induced HR is reduced in the RAD51C deficient cell line CL-V4B, in agreement with a role for RAD51C in HR [7].

Physical interactions of RAD51C

  • We extended these observations to examine the interaction between the RAD51B/RAD51C complex and the other RAD51 paralogs [8].
  • RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51 [8].

Other interactions of RAD51C

  • The RAD51B/RAD51C heterocomplex was isolated and purified by immunoaffinity chromatography from insect cells co-expressing the recombinant proteins [8].
  • Six SNPs have been detected in the DNA repair genes RAD51C and RAD51D, not previously characterized [9].

Analytical, diagnostic and therapeutic context of RAD51C


  1. Interplay between human DNA repair proteins at a unique double-strand break in vivo. Rodrigue, A., Lafrance, M., Gauthier, M.C., McDonald, D., Hendzel, M., West, S.C., Jasin, M., Masson, J.Y. EMBO J. (2006) [Pubmed]
  2. Complex formation by the human RAD51C and XRCC3 recombination repair proteins. Masson, J.Y., Stasiak, A.Z., Stasiak, A., Benson, F.E., West, S.C. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  3. Multiple genes at 17q23 undergo amplification and overexpression in breast cancer. Bärlund, M., Monni, O., Kononen, J., Cornelison, R., Torhorst, J., Sauter, G., Kallioniemi OLLI-P, n.u.l.l., Kallioniemi, A. Cancer Res. (2000) [Pubmed]
  4. Role of RAD51C and XRCC3 in genetic recombination and DNA repair. Liu, Y., Tarsounas, M., O'regan, P., West, S.C. J. Biol. Chem. (2007) [Pubmed]
  5. Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes. Dosanjh, M.K., Collins, D.W., Fan, W., Lennon, G.G., Albala, J.S., Shen, Z., Schild, D. Nucleic Acids Res. (1998) [Pubmed]
  6. Identification of functional domains in the RAD51L2 (RAD51C) protein and its requirement for gene conversion. French, C.A., Tambini, C.E., Thacker, J. J. Biol. Chem. (2003) [Pubmed]
  7. RAD51C (RAD51L2) is involved in maintaining centrosome number in mitosis. Renglin Lindh, A., Schultz, N., Saleh-Gohari, N., Helleday, T. Cytogenet. Genome Res. (2007) [Pubmed]
  8. RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51. Miller, K.A., Yoshikawa, D.M., McConnell, I.R., Clark, R., Schild, D., Albala, J.S. J. Biol. Chem. (2002) [Pubmed]
  9. The variant E233G of the RAD51D gene could be a low-penetrance allele in high-risk breast cancer families without BRCA1/2 mutations. Rodríguez-López, R., Osorio, A., Ribas, G., Pollán, M., Sánchez-Pulido, L., de la Hoya, M., Ruibal, A., Zamora, P., Arias, J.I., Salazar, R., Vega, A., Martínez, J.I., Esteban-Cardeñosa, E., Alonso, C., Letón, R., Urioste Azcorra, M., Miner, C., Armengod, M.E., Carracedo, A., González-Sarmiento, R., Caldés, T., Díez, O., Benítez, J. Int. J. Cancer (2004) [Pubmed]
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