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Gene Review

Gata-5  -  GATA-binding protein 5

Rattus norvegicus

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High impact information on GATA-5


Biological context of GATA-5

  • However, at saturated levels of GATA-4, additional transgene activation was achieved by adding GATA-5 expression construct, and vice versa [4].

Anatomical context of GATA-5

  • Although inactive in most non-cardiac cell lines, its activity can be rescued by cotransfection with GATA-4 and -6, but not GATA-5 transcription factors [5].
  • One family member, GATA-5, is restricted to the endocardium while the other two, GATA-4 and -6, are present in the myocardium where they apparently fulfil distinct functions [6].

Other interactions of GATA-5

  • Pressure overload within 15 to 60 minutes produced an increase in left ventricular BNP GATA4 but not GATA5 and GATA6 binding activity, and at 30 minutes a 2.2-fold increase (P:<0.001) in GATA4 binding was noted [7].

Analytical, diagnostic and therapeutic context of GATA-5

  • Northern blot analysis showed that rat GATA-5 is expressed in a dynamic pattern during embryonic and postnatal development [8].


  1. GATA-5 is involved in leukemia inhibitory factor-responsive transcription of the beta-myosin heavy chain gene in cardiac myocytes. Morimoto, T., Hasegawa, K., Kaburagi, S., Kakita, T., Masutani, H., Kitsis, R.N., Matsumori, A., Sasayama, S. J. Biol. Chem. (1999) [Pubmed]
  2. p300 protein as a coactivator of GATA-5 in the transcription of cardiac-restricted atrial natriuretic factor gene. Kakita, T., Hasegawa, K., Morimoto, T., Kaburagi, S., Wada, H., Sasayama, S. J. Biol. Chem. (1999) [Pubmed]
  3. GATA-6 activates transcription of thyroid transcription factor-1. Shaw-White, J.R., Bruno, M.D., Whitsett, J.A. J. Biol. Chem. (1999) [Pubmed]
  4. Cooperative interactions among intestinal GATA factors in activating the rat liver fatty acid binding protein gene. Divine, J.K., Staloch, L.J., Haveri, H., Rowley, C.W., Heikinheimo, M., Simon, T.C. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  5. A distant upstream region of the rat multipartite Na(+)-Ca(2+) exchanger NCX1 gene promoter is sufficient to confer cardiac-specific expression. Koban, M.U., Brugh, S.A., Riordon, D.R., Dellow, K.A., Yang, H.T., Tweedie, D., Boheler, K.R. Mech. Dev. (2001) [Pubmed]
  6. GATA transcription factors and cardiac development. Charron, F., Nemer, M. Semin. Cell Dev. Biol. (1999) [Pubmed]
  7. Pressure overload increases GATA4 binding activity via endothelin-1. Hautala, N., Tokola, H., Luodonpää, M., Puhakka, J., Romppanen, H., Vuolteenaho, O., Ruskoaho, H. Circulation (2001) [Pubmed]
  8. Functional analysis and chromosomal mapping of Gata5, a gene encoding a zinc finger DNA-binding protein. Nemer, G., Qureshi, S.T., Malo, D., Nemer, M. Mamm. Genome (1999) [Pubmed]
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