High impact information on GATA-5

• Thus, GATA-5 may be involved in gp130 signaling in cardiac myocytes [1].
• Here we show that E1A represses the GATA-5-dependent transactivation of a promoter derived from the cardiac-restricted atrial natriuretic factor gene [2].
• This transactivation was dependent on sequence-specific binding of GATA-5 to the beta-myosin heavy chain GATA element [1].
• A small fragment of p300 containing the carboxyl-terminal cysteine/histidine-rich domain, sufficient to interact with GATA-5, prevents transcriptional activation by GATA-5 as a dominant-negative mutant [2].
• GATA-5 and -6, members of the zinc finger family of transcription factors, are also expressed in various cell types within in the developing lung [3].

Biological context of GATA-5

• However, at saturated levels of GATA-4, additional transgene activation was achieved by adding GATA-5 expression construct, and vice versa [4].

Anatomical context of GATA-5

• Although inactive in most non-cardiac cell lines, its activity can be rescued by cotransfection with GATA-4 and -6, but not GATA-5 transcription factors [5].
• One family member, GATA-5, is restricted to the endocardium while the other two, GATA-4 and -6, are present in the myocardium where they apparently fulfil distinct functions [6].

Other interactions of GATA-5

• Pressure overload within 15 to 60 minutes produced an increase in left ventricular BNP GATA4 but not GATA5 and GATA6 binding activity, and at 30 minutes a 2.2-fold increase (P:<0.001) in GATA4 binding was noted [7].

Analytical, diagnostic and therapeutic context of GATA-5

• Northern blot analysis showed that rat GATA-5 is expressed in a dynamic pattern during embryonic and postnatal development [8].

References