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Gene Review

Hpgds  -  hematopoietic prostaglandin D synthase

Rattus norvegicus

Synonyms: GST class-sigma, Glutathione S-transferase, Glutathione-dependent PGD synthase, Glutathione-requiring prostaglandin D synthase, Gsts, ...
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Disease relevance of Ptgds2

  • Orally administered HQL-79 (30 mg/kg body weight) inhibited antigen-induced production of PGD2, without affecting the production of PGE2 and PGF2alpha, and ameliorated airway inflammation in wild-type and human H-PGDS-overexpressing mice [1].

High impact information on Ptgds2

  • Glutathione-independent prostaglandin D synthase [prostaglandin-H2 D-isomerase; (5Z,13E)-(15S)-9 alpha,11 alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase, EC] is an enzyme responsible for biosynthesis of prostaglandin D2 in the central nervous system [2].
  • Prostaglandin (PG) D2 has been postulated to be an endogenous sleep-promoting factor in rats, and SeCl4 and Na2SeO3 recently have been shown to inhibit the PGD synthase (prostaglandin-H2 D-isomerase, EC activity of rat brain [3].
  • We determined the crystal structure of human hematopoietic prostaglandin (PG) D synthase (H-PGDS) as the quaternary complex with glutathione (GSH), Mg2+, and an inhibitor, HQL-79, having anti-inflammatory activities in vivo, at a 1.45-A resolution [1].
  • HQL-79 inhibited human H-PGDS competitively against the substrate PGH2 and non-competitively against GSH with Ki of 5 and 3 microm, respectively [1].
  • Biosynthesis of PGD2 is catalyzed by PGD synthase (prostaglandin-H2 D-isomerase, EC, the activity of which is inhibited by inorganic selenium compounds such as SeCl4 and Na2SeO3 [4].

Analytical, diagnostic and therapeutic context of Ptgds2


  1. Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. Aritake, K., Kado, Y., Inoue, T., Miyano, M., Urade, Y. J. Biol. Chem. (2006) [Pubmed]
  2. Dominant expression of mRNA for prostaglandin D synthase in leptomeninges, choroid plexus, and oligodendrocytes of the adult rat brain. Urade, Y., Kitahama, K., Ohishi, H., Kaneko, T., Mizuno, N., Hayaishi, O. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  3. Inhibition of sleep in rats by inorganic selenium compounds, inhibitors of prostaglandin D synthase. Matsumura, H., Takahata, R., Hayaishi, O. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  4. Intravenous administration of inorganic selenium compounds, inhibitors of prostaglandin D synthase, inhibits sleep in freely moving rats. Takahata, R., Matsumura, H., Kantha, S.S., Kubo, E., Kawase, K., Sakai, T., Hayaishi, O. Brain Res. (1993) [Pubmed]
  5. Structural basis of hematopoietic prostaglandin D synthase activity elucidated by site-directed mutagenesis. Pinzar, E., Miyano, M., Kanaoka, Y., Urade, Y., Hayaishi, O. J. Biol. Chem. (2000) [Pubmed]
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