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Gene Review

Hpgds  -  hematopoietic prostaglandin D synthase

Mus musculus

Synonyms: GST class-sigma, Glutathione S-transferase, Glutathione-dependent PGD synthase, Glutathione-requiring prostaglandin D synthase, Gsts, ...
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Disease relevance of Ptgds2

  • Orally administered HQL-79 (30 mg/kg body weight) inhibited antigen-induced production of PGD2, without affecting the production of PGE2 and PGF2alpha, and ameliorated airway inflammation in wild-type and human H-PGDS-overexpressing mice [1].

High impact information on Ptgds2

  • HQL-79 inhibited human H-PGDS competitively against the substrate PGH2 and non-competitively against GSH with Ki of 5 and 3 microm, respectively [1].
  • We determined the crystal structure of human hematopoietic prostaglandin (PG) D synthase (H-PGDS) as the quaternary complex with glutathione (GSH), Mg2+, and an inhibitor, HQL-79, having anti-inflammatory activities in vivo, at a 1.45-A resolution [1].
  • CONCLUSION: In this murine air-pouch model of MSU crystal-induced inflammation, retrovirally transfected H-PGDS cDNA could reduce cellular infiltration, at least partly by inhibiting MIP-2 and IL-1beta [2].
  • We evaluated the antiinflammatory effect of retrovirally transfected H-PGDS in order to investigate the role of H-PGDS in monosodium urate monohydrate (MSU) crystal-induced acute inflammation [2].
  • OBJECTIVE: Hematopoietic prostaglandin D synthase (H-PGDS) is a key enzyme in the production of prostaglandin D and its J series metabolites [2].

Anatomical context of Ptgds2


Analytical, diagnostic and therapeutic context of Ptgds2


  1. Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. Aritake, K., Kado, Y., Inoue, T., Miyano, M., Urade, Y. J. Biol. Chem. (2006) [Pubmed]
  2. Inhibition of monosodium urate monohydrate crystal-induced acute inflammation by retrovirally transfected prostaglandin D synthase. Murakami, Y., Akahoshi, T., Hayashi, I., Endo, H., Hashimoto, A., Kono, S., Kondo, H., Kawai, S., Inoue, M., Kitasato, H. Arthritis Rheum. (2003) [Pubmed]
  3. Hematopoietic prostaglandin D synthase is expressed in microglia in the developing postnatal mouse brain. Mohri, I., Eguchi, N., Suzuki, K., Urade, Y., Taniike, M. Glia (2003) [Pubmed]
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