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Gene Review

gst-27  -  Protein GST-27

Caenorhabditis elegans

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Disease relevance of gst-27

  • This stress-responsive GST (Ov-GST-3) possesses only 14 and 21% sequence identity with the other O. volvulus GSTs (Ov-GST-1 and Ov-GST-2, respectively) [1].
  • Glutathione S-transferase (GST) fusion proteins of individual subclones were produced in Escherichia coli, purified by affinity chromatography and evaluated in ELISA using sera from dogs with infections of E. granulosus, Taenia spp. or nematodes, and helminth-free dog sera [2].

High impact information on gst-27


Biological context of gst-27


Associations of gst-27 with chemical compounds

  • GST and P450 genes were affected by estrogen (10(-5) M) and progesterone (10(-5) and 10(-7) M) treatments [6].
  • Cunninghamella elegans grown on Sabouraud dextrose broth had glutathione S-transferase (GST) activity [5].
  • Most of the GSTs identified were of the nematode specific class, however, three Alpha class GSTs, a Pi and a Sigma class GST were also isolated [8].

Analytical, diagnostic and therapeutic context of gst-27

  • The GST fusion protein 10P1 showed a specificity of 100% in ELISA for diagnosis of E. granulosus infection in dogs despite its relatively low sensitivity [2].
  • Comparison by Western blot analysis implied that this fungal GST had no relationship with mammalian alpha-, mu-, and pi-class GSTs, although it showed a small degree of cross-reactivity with a theta-class GST [5].
  • Four subunits of the cytosolic glutathione S-transferase (GST) in Orthosia gothica fed on willow leaves and a semisynthetic bean diet were purified as separate peaks (subunits 1-4) by a two-step gradient elution from a reverse-phase HPLC column after an initial purification by glutathione-Sepharose 1-chloro-2,4-dinitro-benzene (CDNB) [9].


  1. Identification of a stress-responsive Onchocerca volvulus glutathione S-transferase (Ov-GST-3) by RT-PCR differential display. Liebau, E., Eschbach, M.L., Tawe, W., Sommer, A., Fischer, P., Walter, R.D., Henkle-Dührsen, K. Mol. Biochem. Parasitol. (2000) [Pubmed]
  2. A recombinant antigen with potential for serodiagnosis of Echinococcus granulosus infection in dogs. Gasser, R.B., Lightowlers, M.W., Rickard, M.D. Int. J. Parasitol. (1990) [Pubmed]
  3. Tyrosine-phosphorylated Cbl binds to Crk after T cell activation. Sawasdikosol, S., Chang, J.H., Pratt, J.C., Wolf, G., Shoelson, S.E., Burakoff, S.J. J. Immunol. (1996) [Pubmed]
  4. Structural and functional analysis of a glutathione S-transferase from Ascaris suum. Liebau, E., Eckelt, V.H., Wildenburg, G., Teesdale-Spittle, P., Brophy, P.M., Walter, R.D., Henkle-Dührsen, K. Biochem. J. (1997) [Pubmed]
  5. Purification and characterization of a glutathione S-transferase from the fungus Cunninghamella elegans. Cha, C.J., Coles, B.F., Cerniglia, C.E. FEMS Microbiol. Lett. (2001) [Pubmed]
  6. Caenorhabditis elegans as an environmental monitor using DNA microarray analysis. Custodia, N., Won, S.J., Novillo, A., Wieland, M., Li, C., Callard, I.P. Ann. N. Y. Acad. Sci. (2001) [Pubmed]
  7. Molecular phylogeny of glutathione-S-transferases. Snyder, M.J., Maddison, D.R. DNA Cell Biol. (1997) [Pubmed]
  8. Proteomic identification of glutathione S-transferases from the model nematode Caenorhabditis elegans. van Rossum, A.J., Brophy, P.M., Tait, A., Barrett, J., Jefferies, J.R. Proteomics (2001) [Pubmed]
  9. The separation and identification of glutathione S-transferase subunits from Orthosia gothica. Egaas, E., Sandvik, M., Svendsen, N.O., Skaare, J.U. Insect Biochem. Mol. Biol. (1995) [Pubmed]
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