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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Arhgap17  -  Rho GTPase activating protein 17

Rattus norvegicus

Synonyms: Nadrin, Neuron-associated developmentally-regulated protein, Rho GTPase-activating protein 17, Rho-type GTPase-activating protein 17
 
 
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High impact information on Arhgap17

  • We have previously demonstrated that adenovirus-expressed, olfactory cyclic nucleotide-gated channels provide real-time sensors for cAMP produced in subcellular compartments of restricted diffusion near the plasma membrane (Rich, T.C., K.A. Fagan, H. Nakata, J. Schaack, D.M.F. Cooper, and J.W. Karpen. 2000. J. Gen. Physiol. 116:147-161) [1].
  • In addition, transcript levels for the vascular morphogenesis and remodeling-related protein SPARC (Secreted Protein, Acidic and Rich in Cysteine) was also elevated in the B animals [2].
  • Effect of methanolic leaf extract of Cissampelos mucronata A. Rich against indomethacin induced ulcer in rats [3].
  • This study was undertaken to evaluate the hypoglycemic effect of Sclerocarya birrea [(A. Rich.) Hochst.] subspecies caffra (Sond.) Kokwaro [family: Anacardiaceae] stem-bark aqueous extract in normal (normoglycemic) and in streptozotocin (STZ)-treated, diabetic Wistar rats [4].
  • Regulation of systemic blood pressure during small changes in blood volume is partially achieved by blood volume shifts from microcirculation to macrocirculation that cause a decrease in systemic hematocrit [LaForte, A., L. Lee, G. Rich, T. Skalak, and J. Lee. Am. J. Physiol. 262 (Heart Circ. Physiol. 31): H190-H199, 1992] [5].

References

  1. In vivo assessment of local phosphodiesterase activity using tailored cyclic nucleotide-gated channels as cAMP sensors. Rich, T.C., Tse, T.E., Rohan, J.G., Schaack, J., Karpen, J.W. J. Gen. Physiol. (2001) [Pubmed]
  2. Immediate postnatal rat heart development modified by abdominal aortic banding: analysis of gene expression. Engelmann, G.L., Campbell, S.E., Rakusan, K. Mol. Cell. Biochem. (1996) [Pubmed]
  3. Effect of methanolic leaf extract of Cissampelos mucronata A. Rich against indomethacin induced ulcer in rats. Nwafor, S.V., Akah, P.A. Indian J. Exp. Biol. (2003) [Pubmed]
  4. Hypoglycemic effect of Sclerocarya birrea [(A. Rich.) Hochst.] [Anacardiaceae] stem-bark aqueous extract in rats. Ojewole, J.A. Phytomedicine (2003) [Pubmed]
  5. Microvascular volume contribution to hemorrhage compensation. Price, R.J., Lee, J.S., Skalak, T.C. Am. J. Physiol. (1993) [Pubmed]
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