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Gene Review

NPFFR1  -  neuropeptide FF receptor 1

Homo sapiens

Synonyms: G-protein coupled receptor 147, GPR147, NPFF1, NPFF1R1, Neuropeptide FF receptor 1, ...
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Disease relevance of NPFFR1


High impact information on NPFFR1


Anatomical context of NPFFR1


Associations of NPFFR1 with chemical compounds


Other interactions of NPFFR1

  • The FP HTS system provides a specific, sensitive and reproducible methodology for studying and screening NPFF receptor ligands [9].

Analytical, diagnostic and therapeutic context of NPFFR1

  • The seemingly promiscuous binding of the RFamide peptides to the NPFF receptor was further confirmed by receptor autoradiography [5].
  • In contrast, two high anti-peptide ELISA titer but celTRF-negative antibodies failed to recognize the NPFF1 receptor in IHC [10].


  1. RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. Simonin, F., Schmitt, M., Laulin, J.P., Laboureyras, E., Jhamandas, J.H., MacTavish, D., Matifas, A., Mollereau, C., Laurent, P., Parmentier, M., Kieffer, B.L., Bourguignon, J.J., Simonnet, G. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. Neuropeptide FF, a mammalian neuropeptide with multiple functions. Panula, P., Aarnisalo, A.A., Wasowicz, K. Prog. Neurobiol. (1996) [Pubmed]
  3. Neuropeptide AF and FF modulation of adipocyte metabolism. Primary insights from functional genomics and effects on beta-adrenergic responsiveness. Lefrere, I., De Coppet, P., Camelin, J.C., Le Lay, S., Mercier, N., Elshourbagy, N., Bril, A., Berrebi-Bertrand, I., Feve, B., Krief, S. J. Biol. Chem. (2002) [Pubmed]
  4. Regulation of endogenous human NPFF2 receptor by neuropeptide FF in SK-N-MC neuroblastoma cell line. Ankö, M.L., Panula, P. J. Neurochem. (2006) [Pubmed]
  5. Prolactin releasing peptide has high affinity and efficacy at neuropeptide FF2 receptors. Engström, M., Brandt, A., Wurster, S., Savola, J.M., Panula, P. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  6. Functional characterization of a human receptor for neuropeptide FF and related peptides. Kotani, M., Mollereau, C., Detheux, M., Le Poul, E., Brézillon, S., Vakili, J., Mazarguil, H., Vassart, G., Zajac, J.M., Parmentier, M. Br. J. Pharmacol. (2001) [Pubmed]
  7. Modulatory roles of the NPFF system in pain mechanisms at the spinal level. Yang, H.Y., Iadarola, M.J. Peptides (2006) [Pubmed]
  8. Functional properties of Pfr(Tic)amide and BIBP3226 at human neuropeptide FF2 receptors. Engström, M., Wurster, S., Savola, J.M., Panula, P. Peptides (2003) [Pubmed]
  9. The high throughput screening of neuropeptide FF2 receptor ligands from Korean herbal plant extracts. Do, E.U., Piao, L.Z., Choi, G., Choi, Y.B., Kang, T.M., Shin, J., Chang, Y.J., Nam, H.Y., Kim, H.J., Kim, S.I. Peptides (2006) [Pubmed]
  10. A cell-based time-resolved fluorescence assay for selection of antibody reagents for G protein-coupled receptor immunohistochemistry. Su, J.L., Fornwald, J., Rivers, P., Goldsworthy, S., Looney, N.A., Hanvey, J., Plumpton, C., Parham, J., Romanos, M., Kost, T.A., Kull, F.C. J. Immunol. Methods (2004) [Pubmed]
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