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Gene Review

Est1  -  alpha-esterase like protein E2

Tribolium castaneum

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Disease relevance of est1


High impact information on est1

  • Malathion-specific resistance is due to the presence of a qualitatively different esterase in the resistant strain [3].
  • Effect of octopamine on the activity of juvenile-hormone esterase in the silkworm Bombyx mori and the red flour beetle Tribolium freemani [4].
  • The remarkable tolerance of the predator Chrysopa carnea to pyrethroids is attributed to the presence of a high level of pyrethroid esterase activity with a unique specificity for hydrolyzing the cis-isomer [2].
  • Using paraoxon and pirimiphos-methyl oxon as substrates, high "A" esterase activity is found in the liver and plasma or serum of a range of mammalian species [5].


  1. Expression of a synthetic gene encoding a Tribolium castaneum carboxylesterase in Pichia pastoris. Delroisse, J.M., Dannau, M., Gilsoul, J.J., El Mejdoub, T., Destain, J., Portetelle, D., Thonart, P., Haubruge, E., Vandenbol, M. Protein Expr. Purif. (2005) [Pubmed]
  2. Insect detoxifying enzymes: their importance in pesticide synergism and resistance. Ishaaya, I. Arch. Insect Biochem. Physiol. (1993) [Pubmed]
  3. Purification and characterization of a carboxylesterase involved in malathion-specific resistance from Tribolium castaneum (Coleoptera: Tenebrionidae). Haubruge, E., Amichot, M., Cuany, A., Berge, J.B., Arnaud, L. Insect Biochem. Mol. Biol. (2002) [Pubmed]
  4. Effect of octopamine on the activity of juvenile-hormone esterase in the silkworm Bombyx mori and the red flour beetle Tribolium freemani. Hirashima, A., Suetsugu, E., Hirokado, S., Kuwano, E., Taniguchi, E., Eto, M. Gen. Comp. Endocrinol. (1999) [Pubmed]
  5. "A" esterases and their role in regulating the toxicity of organophosphates. Walker, C.H., Mackness, M.I. Arch. Toxicol. (1987) [Pubmed]
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