Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Est1 - alpha-esterase like protein E2

Tribolium castaneum

Ishaaya, I., Delroisse, J.M. et al., Walker, C.H. et al., Hirashima, A. et al., Haubruge, E. et al.

Hirashima, Suetsugu, Hirokado, Kuwano, Taniguchi, Eto,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of est1

This is the first report of an insect esterase efficiently expressed in the methylotrophic yeast Pichia pastoris (so far insect esterases have been produced only in the baculovirus system) [1].
Monocrotophos, profenofos, acephate, and methidathion inhibited pyrethroid esterase activity in B. tabaci and synergized considerably the toxicity of cypermethrin [2].

High impact information on est1

Malathion-specific resistance is due to the presence of a qualitatively different esterase in the resistant strain [3].
Effect of octopamine on the activity of juvenile-hormone esterase in the silkworm Bombyx mori and the red flour beetle Tribolium freemani [4].
The remarkable tolerance of the predator Chrysopa carnea to pyrethroids is attributed to the presence of a high level of pyrethroid esterase activity with a unique specificity for hydrolyzing the cis-isomer [2].
Using paraoxon and pirimiphos-methyl oxon as substrates, high "A" esterase activity is found in the liver and plasma or serum of a range of mammalian species [5].

References

Expression of a synthetic gene encoding a Tribolium castaneum carboxylesterase in Pichia pastoris. Delroisse, J.M., Dannau, M., Gilsoul, J.J., El Mejdoub, T., Destain, J., Portetelle, D., Thonart, P., Haubruge, E., Vandenbol, M. Protein Expr. Purif. (2005) [Pubmed]
Insect detoxifying enzymes: their importance in pesticide synergism and resistance. Ishaaya, I. Arch. Insect Biochem. Physiol. (1993) [Pubmed]
Purification and characterization of a carboxylesterase involved in malathion-specific resistance from Tribolium castaneum (Coleoptera: Tenebrionidae). Haubruge, E., Amichot, M., Cuany, A., Berge, J.B., Arnaud, L. Insect Biochem. Mol. Biol. (2002) [Pubmed]
Effect of octopamine on the activity of juvenile-hormone esterase in the silkworm Bombyx mori and the red flour beetle Tribolium freemani. Hirashima, A., Suetsugu, E., Hirokado, S., Kuwano, E., Taniguchi, E., Eto, M. Gen. Comp. Endocrinol. (1999) [Pubmed]
"A" esterases and their role in regulating the toxicity of organophosphates. Walker, C.H., Mackness, M.I. Arch. Toxicol. (1987) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.