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Chemical Compound Review

Actellic     4- dimethoxyphosphinothioyloxy- N,N-diethyl...

Synonyms: Aktellik, Actelic, Aktelik, Silosan, Actellifog, ...
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Disease relevance of Pyrimiphos methyl


Psychiatry related information on Pyrimiphos methyl


High impact information on Pyrimiphos methyl


Chemical compound and disease context of Pyrimiphos methyl


Biological context of Pyrimiphos methyl


Anatomical context of Pyrimiphos methyl

  • When the hepatocytes were exposed to the two pesticides together at increasing doses, an enhancement in micronucleus frequency similar to that of benomyl alone was found, indicating that at this ratio and non-cytotoxic doses (up to 25 micrograms/ml benomyl + 4.2 micrograms/ml pirimiphos-methyl) no interaction occurs [7].
  • NTE activities in the brain and spinal cord of pirimiphos-methyl-treated hens were identical to those in the controls, while they were profoundly inhibited (greater than 80%) in the TOCP-treated hens [1].

Associations of Pyrimiphos methyl with other chemical compounds

  • Survival of chironomids within the in situ systems commenced on day +16 after treatment with 31.6% and 53.3% survival in the lindane and PM treated ponds, respectively [9].
  • The susceptibilities of field strains (Fl) of Aedes aegypti and Ae. albopictus adult females to pirimiphos-methyl and permethrin were investigated and compared with a susceptible laboratory strain (S) by using a filter paper (12 x 15 cm) impregnation method [19].
  • Malathion and pyrethroid resistance in Culex quinquefasciatus from Cuba: efficacy of pirimiphos-methyl in the presence of at least three resistance mechanisms [20].
  • Densities of Anopheles annularis Van der Wulp, An. culicifacies Giles, An. fluviatilis Theobald and other potential malaria vectors were reduced in the pirimiphos-methyl trial area 2-35-fold more than in the area sprayed with DDT [21].
  • Deliberately holed bednets freshly treated with pirimiphos-methyl or carbosulfan caused over 90% kill of A. gambiae s.s. and Culex spp [13].

Gene context of Pyrimiphos methyl

  • Hens dosed with pirimiphos-methyl had very low AChE activities (less than 20% of control) in both the brain and spinal cord, 24 and 48 h after dosing [1].
  • Using paraoxon and pirimiphos-methyl oxon as substrates, high "A" esterase activity is found in the liver and plasma or serum of a range of mammalian species [22].
  • A comparison, on a village scale, of the effect of pirimiphos-methyl and DDT on Anopheles balabacensis - vectored malaria [23].
  • Observations made for a period of four years from 1985 to 1988 on post-spray impact of pirimiphos-methyl (25 per cent Wp) on malaria vectors in Tirap district of Arunachal Pradesh showed that a low density (0.0 to 0.02 PMH) of Anopheles dirus was maintained in the areas sprayed with the insecticide at the dosages of 1 and 2 g/m2 from 1981 to 1984 [24].
  • Activities of all enzymes (excepting Brain AChE) returned to normal levels following a 7-day maintenance on the insecticide-free diet implicating that pirimiphos-methyl induced little or no permanent tissue damage [25].

Analytical, diagnostic and therapeutic context of Pyrimiphos methyl

  • Clarias albopunctatus fingerlings were subjected to sublethal concentrations (0, 0.3, 0. 5, 0.8, and 1.0microg/L) of actellic for 18 days in a static bioassay system [2].
  • To detect the organophosphorus (OP) pesticide pirimiphos-methyl in grain samples, a monoclonal antibody-based indirect competitive enzyme-linked immunosorbent assay (IC-ELISA) was developed and optimized [26].


  1. Delayed neuropathy and acute toxicity studies with pirimiphos-methyl in the hen. Lock, E.A., Johnson, M.K. Journal of applied toxicology : JAT. (1990) [Pubmed]
  2. Erythropoietic response and hematological parameters in the catfish Clarias albopunctatus exposed to sublethal concentrations of actellic. Mgbenka, B.O., Oluah, N.S., Arungwa, A.A. Ecotoxicol. Environ. Saf. (2005) [Pubmed]
  3. Efficacy of diethylcarbamazine and pirimiphos-methyl residual spraying in controlling brugian filariasis. Chang, M.S., Ho, B.C., Chan, K.L. Trop. Med. Parasitol. (1991) [Pubmed]
  4. Evaluation of biological and chemical insecticide mixture against Aedes aegypti larvae and adults by thermal fogging in Singapore. Chung, Y.K., Lam-Phua, S.G., Chua, Y.T., Yatiman, R. Med. Vet. Entomol. (2001) [Pubmed]
  5. Bioavailability to rats of bound [14C] pirimiphos-methyl in stored wheat. Khan, S.U., Kacew, S., Matthews, W. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. (1992) [Pubmed]
  6. Side-effects of three pesticides on the predatory mite, Phytoseiulus persimilis (Acari: Phytoseiidae). Kavousi, A., Talebi, K. Exp. Appl. Acarol. (2003) [Pubmed]
  7. Increase of micronucleus frequency in cultured rat hepatocytes treated in vitro with benomyl and pirimiphos-methyl separately and in mixture. Piatti, E., Marabini, L., Chiesara, E. Mutat. Res. (1994) [Pubmed]
  8. Genotoxicity assay of five pesticides and their mixtures in Saccharomyces cerevisiae D7. Bianchi, L., Zannoli, A., Pizzala, R., Stivala, L.A., Chiesara, E. Mutat. Res. (1994) [Pubmed]
  9. Incorporation of in situ and biomarker assays in higher-tier assessment of the aquatic toxicity of insecticides. Maycock, D.S., Prenner, M.M., Kheir, R., Morris, S., Callaghan, A., Whitehouse, P., Morritt, D., Crane, M. Water Res. (2003) [Pubmed]
  10. Pesticide content of infant formulae and weaning foods available in New Zealand. Cressey, P.J., Vannoort, R.W. Food additives and contaminants. (2003) [Pubmed]
  11. Effect of L-ascorbic acid supplementation on the toxicity of pirimiphos-methyl to albino rats. Rajini, P.S., Krishnakumari, M.K. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition. (1985) [Pubmed]
  12. Botanical biocides. 4. Mosquitocidal activity of certain Thymus capitatus constituents. Mansour, S.A., Messeha, S.S., el-Gengaihi, S.E. Journal of natural toxins. (2000) [Pubmed]
  13. Experimental and molecular genetic analysis of the impact of pyrethroid and non-pyrethroid insecticide impregnated bednets for mosquito control in an area of pyrethroid resistance. Kolaczinski, J.H., Fanello, C., Hervé, J.P., Conway, D.J., Carnevale, P., Curtis, C.F. Bull. Entomol. Res. (2000) [Pubmed]
  14. Dermal toxicity of hexachlorocyclohexane and pirimiphos-methyl in female rats. Raizada, R.B., Srivastava, M.K., Kaushal, R.A., Singh, R.P., Gupta, K.P., Dikshith, T.S. Veterinary and human toxicology. (1994) [Pubmed]
  15. Sublethal effects of mosquito larvicides on swimming performance of larvivorous fish Melanotaenia duboulayi (Atheriniformes: Melanotaeniidae). Hurst, T.P., Kay, B.H., Ryan, P.A., Brown, M.D. J. Econ. Entomol. (2007) [Pubmed]
  16. Bioavailability and toxicological potential of wheat-bound pirimiphos-methyl residues in rats. Akay, M.T., Yilmazoğlu, G., Yaşacan, S., Turk, H., Kolanyaka, D. Xenobiotica (1992) [Pubmed]
  17. Susceptibility of laboratory-reared northern fowl mites, Ornithonyssus sylviarum (Acari: Macronyssidae), to selected acaricides. Crystal, M.M., DeMilo, A.B. Exp. Appl. Acarol. (1988) [Pubmed]
  18. Persistence and residual activity of an organophosphate, pirimiphos-methyl, and three IGRs, hexaflumuron, teflubenzuron and pyriproxyfen, against the cowpea weevil, Callosobruchus maculatus (Coleoptera: Bruchidae). Abo-Elghar, G.E., El-Sheikh, A.E., El-Sayed, F.M., El-Maghraby, H.M., El-Zun, H.M. Pest Manag. Sci. (2004) [Pubmed]
  19. Susceptibility of adult field strains of Aedes aegypti and Aedes albopictus in Singapore to pirimiphos-methyl and permethrin. Ping, L.T., Yatiman, R., Gek, L.P. J. Am. Mosq. Control Assoc. (2001) [Pubmed]
  20. Malathion and pyrethroid resistance in Culex quinquefasciatus from Cuba: efficacy of pirimiphos-methyl in the presence of at least three resistance mechanisms. Bisset, J.A., Rodriguez, M.M., Hemingway, J., Diaz, C., Small, G.J., Ortiz, E. Med. Vet. Entomol. (1991) [Pubmed]
  21. Field trial of the effectiveness of indoor-spraying with pirimiphos-methyl emulsion for malaria control in a tribal area of Phulbani district, Orissa State, India. Das, M., Srivastava, B.N., Rao, C.K., Thapar, B.R., Sharma, G.K. Med. Vet. Entomol. (1987) [Pubmed]
  22. "A" esterases and their role in regulating the toxicity of organophosphates. Walker, C.H., Mackness, M.I. Arch. Toxicol. (1987) [Pubmed]
  23. A comparison, on a village scale, of the effect of pirimiphos-methyl and DDT on Anopheles balabacensis - vectored malaria. Pattanayak, S., Samnotra, K.G., Seni, A. The Journal of tropical medicine and hygiene. (1980) [Pubmed]
  24. Malaria transmission during post-spray period of pirimiphos-methyl in Arunachal Pradesh. Biswas, H., Yadava, R.L., Rao, C.K., Thapar, B.R., Narasimham, M.V. The Journal of communicable diseases. (1992) [Pubmed]
  25. Inhibitory pattern of tissue esterases in rats fed dietary pirimiphos-methyl. Rajini, P.S., Muralidhara, n.u.l.l., Krishnakumari, M.K. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. (1989) [Pubmed]
  26. Development of monoclonal antibodies against pirimiphos-methyl and their application to IC-ELISA. Yang, Z.Y., Kolosova, A.Y., Shim, W.B., Chung, D.H. J. Agric. Food Chem. (2006) [Pubmed]
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