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Chemical Compound Review

Nuvacron     (E)-3-dimethoxyphosphoryloxy- N-methyl-but...

Synonyms: Aimocron, Biloborn, Bilobran, Corophos, Hazodrin, ...
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Disease relevance of Nuvacron


High impact information on Nuvacron


Chemical compound and disease context of Nuvacron


Biological context of Nuvacron

  • In cells incubated with 20 micrograms/ml of the various chemicals, the number of M1 metaphases ranged from 6% (R-1303) to 18% (Azodrin) compared to no M1 metaphases in control cultures [14].
  • The genotoxic effects of five pesticides (benomyl, 2,4-D, dimecron, monocrotophos, and vitavax) were evaluated in the rat bone marrow cytogenetic assay [15].
  • The degradation of monocrotophos at both concentrations in black vertisol and red alfinsol soils was rapid accounting for 96-98% of the applied quantity and followed the first-order kinetics with rate constants (k) of 0.0753 and 0.0606 day(-1) and half-lives (t1/2) of 9.2 and 11.4 days, respectively [16].
  • METABOLISM: The biotransformation of monocrotophos is well understood [17].
  • A significant increase in mean comet tail-length (5.21-7.46 microM), indicating DNA damage, was observed at all the doses with monocrotophos when compared to controls (3.36 microM) [18].

Anatomical context of Nuvacron


Associations of Nuvacron with other chemical compounds


Gene context of Nuvacron


Analytical, diagnostic and therapeutic context of Nuvacron


  1. Rapid X-ray diffraction analysis of HIV-1 protease-inhibitor complexes: inhibitor exchange in single crystals of the bound enzyme. Munshi, S., Chen, Z., Li, Y., Olsen, D.B., Fraley, M.E., Hungate, R.W., Kuo, L.C. Acta Crystallogr. D Biol. Crystallogr. (1998) [Pubmed]
  2. Reproductive toxicity of monocrotophos to bobwhite quail. Stromborg, K.L. Poult. Sci. (1986) [Pubmed]
  3. Isolation and characterization of a denitrifying monocrotophos-degrading Paracoccus sp. M-1. Jia, K.Z., Cui, Z.L., He, J., Guo, P., Li, S.P. FEMS Microbiol. Lett. (2006) [Pubmed]
  4. Utilization of monocrotophos as phosphorus source by Pseudomonas aeruginosa F10B and Clavibacter michiganense subsp. insidiosum SBL 11. Singh, S., Singh, D.K. Can. J. Microbiol. (2003) [Pubmed]
  5. Haemotoxicity to chicken (Gallus gallus domesticus) by technical and formulation grades of some phosphoric and synthetic pyrethroid esters. Qadri, S.S., Jabeen, K., Mahboob, M., Mustafa, M. Journal of applied toxicology : JAT. (1987) [Pubmed]
  6. Determination of cis and trans isomers of monocrotophos in technical products by reversed-phase column liquid chromatography. Ismail, N., Vairamani, M., Rao, R.N. Journal of chromatography. A. (2000) [Pubmed]
  7. Studies on the genotoxicity of monocrotophos, an organophosphate insecticide, in the chick in vivo test system. Bhunya, S.P., Jena, G.B. Mutat. Res. (1993) [Pubmed]
  8. Studies on the genotoxicity of monocrotophos in somatic and germ-like cells of Drosophila. Tripathy, N.K., Patnaik, K.K. Mutat. Res. (1992) [Pubmed]
  9. Frequencies of chromosomal aberrations in smokers exposed to pesticides in cotton fields. Rupa, D.S., Reddy, P.P., Reddi, O.S. Mutat. Res. (1989) [Pubmed]
  10. Partition distribution of insecticides as a critical factor affecting their rates of absorption from water and relative toxicities to fish. Yang, C.F., Sun, Y.P. Arch. Environ. Contam. Toxicol. (1977) [Pubmed]
  11. Effects of monocrotophos and its analogs in acetylcholinesterase activity's inhibition and its pattern of recovery on euryhaline fish, Oreochromis mossambicus. Rao, J.V. Ecotoxicol. Environ. Saf. (2004) [Pubmed]
  12. Effect of chlorpyrifos and monocrotophos on locomotor behaviour and acetylcholinesterase activity of subterranean termites, Odontotermes obesus. Venkateswara Rao, J., Parvathi, K., Kavitha, P., Jakka, N.M., Pallela, R. Pest Manag. Sci. (2005) [Pubmed]
  13. Effect of monocrotophos and quinalphos on soil population and nitrogen-fixing activity of Azospirillum sp. Rangaswamy, V., Charyulu, P.B., Venkateswarlu, K. Biomed. Environ. Sci. (1989) [Pubmed]
  14. Cytokinetic and cytogenetic effects of some agricultural chemicals on human lymphoid cells in vitro: organophosphates. Sobti, R.C., Krishan, A., Pfaffenberger, C.D. Mutat. Res. (1982) [Pubmed]
  15. Genotoxic effects of some systemic pesticides: in vivo chromosomal aberrations in bone marrow cells in rats. Adhikari, N., Grover, I.S. Environ. Mol. Mutagen. (1988) [Pubmed]
  16. Degradation of monocrotophos in soils. Gundi, V.A., Reddy, B.R. Chemosphere (2006) [Pubmed]
  17. Metabolism of monocrotophos in animals. Mücke, W. Reviews of environmental contamination and toxicology. (1994) [Pubmed]
  18. Genotoxic effect of monocrotophos to sentinel species using comet assay. Saleha Banu, B., Danadevi, K., Rahman, M.F., Ahuja, Y.R., Kaiser, J. Food Chem. Toxicol. (2001) [Pubmed]
  19. Induction of sister-chromatid exchanges by pesticides in primary rat tracheal epithelial cells and Chinese hamster ovary cells. Wang, T.C., Lee, T.C., Lin, M.F., Lin, S.Y. Mutat. Res. (1987) [Pubmed]
  20. Toxicological effects of aerial application of monocrotophos. Rao, R.R., Quadros, F., Mazmudar, R.M., Marathe, M.R., Gangoli, S.D. Arch. Environ. Contam. Toxicol. (1980) [Pubmed]
  21. Inhibition of interleukin 2 driven proliferation of mouse CTLL2 cells, by selected carbamate and organophosphate insecticides and congeners of carbaryl. Casale, G.P., Vennerstrom, J.L., Bavari, S., Wang, T.L. Immunopharmacology and immunotoxicology. (1993) [Pubmed]
  22. Monocrotophos induced dysfunction on estrous cycle and follicular development in mice. Rao, R.P., Kaliwal, B.B. Industrial health. (2002) [Pubmed]
  23. Influence of cypermethrin and fenvalerate on natural soil algal populations. Megharaj, M., Venkateswarlu, K., Rao, A.S. Ecotoxicol. Environ. Saf. (1986) [Pubmed]
  24. Establishment of reentry intervals for organophosphate-treated cotton fields based on human data: III. 12 To 72 hours post-treatment exposure to monocrotophos, ethyl- and methyl parathion. Ware, G.W., Morgan, D.P., Estesen, B.J., Cahill, W.P. Arch. Environ. Contam. Toxicol. (1975) [Pubmed]
  25. Decomposition of monocrotophos in aqueous solution by UV irradiation in the presence of titanium dioxide. Ku, Y., Jung, I.L. Chemosphere (1998) [Pubmed]
  26. Effects of plant species, age and part on the disappearance of sevin, nuvacron and malathion residues. Rawash, I.A., Gaaboub, I.A., El-Gayar, F.M., El-Shazli, A.Y. Toxicology (1975) [Pubmed]
  27. Treatment of monocrotophos-poisoned birds of prey with pralidoxime iodide. Shlosberg, A. J. Am. Vet. Med. Assoc. (1976) [Pubmed]
  28. Serotonin and benzylamine oxidation by type A and type B MAO of rat brain in presence of organophosphate pesticides. Nag, M., Nandy, N. Indian J. Exp. Biol. (2001) [Pubmed]
  29. Species differences in brain acetylcholinesterase response to monocrotophos in vitro. Qadri, Y.H., Swamy, A.N., Rao, J.V. Ecotoxicol. Environ. Saf. (1994) [Pubmed]
  30. Toxicity of azodrin on the morphology and acetylcholinesterase activity of the earthworm Eisenia foetida. Rao, J.V., Kavitha, P. Environmental research. (2004) [Pubmed]
  31. In vitro brain acetylcholinesterase response among three inbred strains of mice to monocrotophos. Rao, J.V., Swamy, A.N., Yamin, S. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. (1991) [Pubmed]
  32. Species differences in brain acetylcholinesterase and neuropathic target esterase response to monocrotophos. Siddiqui, M.K., Rahman, M.F., Mahboob, M., Anjum, F., Mustafa, M. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. (1988) [Pubmed]
  33. Toxicological effects of monocrotophos on microorganisms in the rumen of Bubalus bubalis. Sandhu, H.S., Singh, T.J. Toxicol. Lett. (1989) [Pubmed]
  34. Effect of exposure of human volunteers to the aerial spray of monocrotophos. Rao, R.R., Marathe, M.R., Gangoli, S.D. Ecotoxicol. Environ. Saf. (1979) [Pubmed]
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