Disease relevance of Somonil

• We examined the effect of subacute methidathion (MD) administration on vascular wall damage and evaluated the ameliorating effects of combination of vitamins E and C against MD toxicity [1].

High impact information on Somonil

• Methidathion (MD) is one of the most widely used organophosphate insecticides (OPIs) for public health programmes and agricultural purposes [2].
• The purpose of this study was to evaluate the cytochrome P450-dependent monooxygenase activities in methidathion resistant and susceptible strains of Amblyseius womersleyi Schicha [3].
• The effects of subchronic methidathion toxicity on rat liver: Role of antioxidant vitamins C and E [4].
• The effects of methidathion on lipid peroxidation and some liver enzymes: role of vitamins E and C [5].
• The batch experiments showed an abiotic hydrolysis of methidathion over the experiment period of 4 d, accelerated by alkaline conditions (pH 10.5 and 12.8) and high temperatures (55 degrees C) [6].

Biological context of Somonil

• Methidathion was not genotoxic in a variety of in vitro or in vivo tests designed to detect DNA damage, chromosome aberrations, gene mutations, and sister chromatid exchange [7].
• Aldicarb and methidathion induced a significant increase in SCEs in human lymphocytes in vitro only without the metabolic activating system: aldicarb, 5 microM, 24 h incubation: 15.5 SCE/metaphase; control: 12.6 SCE/metaphase; methidathion, 100 microM, 24 h incubation: 15.8 SCE/metaphase, control: 11.1 SCE/metaphase [8].

Anatomical context of Somonil

• The effects of organophosphate insecticide methidathion on lipid peroxidation and anti-oxidant enzymes in rat erythrocytes: role of vitamins E and C [9].
• Methidathion was present in the plasma until the sixth day, in the urine until the seventh and in the gastric juice until the eighth [10].
• PQ damaged first of all the gills and methidathion had an effect on the skeletal muscles [11].

Associations of Somonil with other chemical compounds

• Ninety-seven agricultural workers were monitored for absorption of the organophosphorus pesticides methidathion, vamidothion, and azinphos-methyl, which were sprayed in an orchard during two seasons [12].
• Residues in wine stored at 24 degrees C dissipated by hydrolysis; half-lives in wine were 7 days for dialifor and methidathion and 30 days for dimethoate [13].
• In the gas chromatography-mass spectrometric screening, trichlorfon and methidathion were detected in his gastric contents [14].
• Determination of urinary metabolites of phosalone, methidathion, and IBP after oral administration and dermal application to rats [15].

Gene context of Somonil

• Half-life values for methidathion in orange and peach juices, respectively, were 4.1 and 3.8 days for storage at 40 degrees C, 115 and 113 days for storage at 15 degrees C, and 330 and 385 days for storage at 0 degrees C. Activation energies for methidathion degradation in orange and peach juices were 22.6 and 21.7 kcal/mol, respectively [16].

References