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Chemical Compound Review

Ultracid     3- (dimethoxyphosphinothioylsulfa nylmethyl)...

Synonyms: SUPRACIDE, Somonil, Ultracide, Metidation, Suprathion, ...
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Disease relevance of Somonil

  • We examined the effect of subacute methidathion (MD) administration on vascular wall damage and evaluated the ameliorating effects of combination of vitamins E and C against MD toxicity [1].

High impact information on Somonil

  • Methidathion (MD) is one of the most widely used organophosphate insecticides (OPIs) for public health programmes and agricultural purposes [2].
  • The purpose of this study was to evaluate the cytochrome P450-dependent monooxygenase activities in methidathion resistant and susceptible strains of Amblyseius womersleyi Schicha [3].
  • The effects of subchronic methidathion toxicity on rat liver: Role of antioxidant vitamins C and E [4].
  • The effects of methidathion on lipid peroxidation and some liver enzymes: role of vitamins E and C [5].
  • The batch experiments showed an abiotic hydrolysis of methidathion over the experiment period of 4 d, accelerated by alkaline conditions (pH 10.5 and 12.8) and high temperatures (55 degrees C) [6].

Biological context of Somonil


Anatomical context of Somonil


Associations of Somonil with other chemical compounds


Gene context of Somonil

  • Half-life values for methidathion in orange and peach juices, respectively, were 4.1 and 3.8 days for storage at 40 degrees C, 115 and 113 days for storage at 15 degrees C, and 330 and 385 days for storage at 0 degrees C. Activation energies for methidathion degradation in orange and peach juices were 22.6 and 21.7 kcal/mol, respectively [16].


  1. Vascular wall damage in rats induced by methidathion and ameliorating effect of vitamins E and C. Yavuz, T., Delibas, N., Yildirim, B., Altuntas, I., Candir, O., Cora, A., Karaman, N., Ibrisim, E., Kutsal, A. Arch. Toxicol. (2004) [Pubmed]
  2. The effects of methidathion on liver: role of vitamins E and C. Gokalp, O., Gulle, K., Sulak, O., Cicek, E., Altuntas, I. Toxicology and industrial health. (2003) [Pubmed]
  3. Monooxygenase Activity in Methidathion Resistant and Susceptible Populations of Amblyseius womersleyi (Acari: Phytoseiidae). Sato, M.E., Tanaka, T., Miyata, T. Exp. Appl. Acarol. (2006) [Pubmed]
  4. The effects of subchronic methidathion toxicity on rat liver: Role of antioxidant vitamins C and E. Sutcu, R., Altuntas, I., Yildirim, B., Karahan, N., Demirin, H., Delibas, N. Cell Biol. Toxicol. (2006) [Pubmed]
  5. The effects of methidathion on lipid peroxidation and some liver enzymes: role of vitamins E and C. Altuntas, I., Delibas, N., Demirci, M., Kilinc, I., Tamer, N. Arch. Toxicol. (2002) [Pubmed]
  6. Fate of methidathion residues in biological waste during anaerobic digestion. Vorkamp, K., Kellner, E., Taube, J., Möller, K.D., Herrmann, R. Chemosphere (2002) [Pubmed]
  7. Evaluation of the carcinogenic potential of pesticides. 2. Methidathion. Quest, J.A., Copley, M.P., Hamernik, K.L., Rinde, E., Fisher, B., Engler, R., Burnam, W.L., Fenner-Crisp, P.A. Regulatory toxicology and pharmacology : RTP. (1990) [Pubmed]
  8. Genotoxicity of selected pesticides in the mouse bone-marrow micronucleus test and in the sister-chromatid exchange test with human lymphocytes in vitro. Kevekordes, S., Gebel, T., Pav, K., Edenharder, R., Dunkelberg, H. Toxicol. Lett. (1996) [Pubmed]
  9. The effects of organophosphate insecticide methidathion on lipid peroxidation and anti-oxidant enzymes in rat erythrocytes: role of vitamins E and C. Altuntas, I., Delibas, N., Sutcu, R. Human & experimental toxicology. (2002) [Pubmed]
  10. Acute poisoning with methidathion: a case. Zoppellari, R., Targa, L., Tonini, P., Zatelli, R. Human & experimental toxicology. (1990) [Pubmed]
  11. Effect of pesticides on the LDH activity and isoenzyme pattern of carp (Cyprinus carpio L.) sera. Asztalos, B., Nemcsók, J. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1985) [Pubmed]
  12. Dialkylphosphorus metabolites in the urine and activities of esterases in the serum as biochemical indices for human absorption of organophosphorus pesticides. Drevenkar, V., Radić, Z., Vasilić, Z., Reiner, E. Arch. Environ. Contam. Toxicol. (1991) [Pubmed]
  13. Behavior of dialifor, dimethoate, and methidathion in artificially fortified grape juice processed into wine. Kawar, N.S., Iwata, Y., Düsch, M.E., Gunther, F.A. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. (1979) [Pubmed]
  14. A case of fatal trichlorfon and methidathion poisoning. Arao, T., Fuke, C., Takaesu, H., Morinaga, Y., Miyazaki, T. Legal medicine (Tokyo, Japan) (2002) [Pubmed]
  15. Determination of urinary metabolites of phosalone, methidathion, and IBP after oral administration and dermal application to rats. Min, K.J., Cha, C.G., Popendorf, W. Bulletin of environmental contamination and toxicology. (2005) [Pubmed]
  16. Effect of storage temperature on degradation of methidathion in fortified orange and peach juices. Kyriakidis, N.B., Athanasopoulos, P., Georgitsanakou, I., Kyriakidis, N.B., Athanasopoulos, P., Georgitsanakou, I. Journal of AOAC International. (2000) [Pubmed]
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