Disease relevance of Surf1

• The aim of this study was to assess whether SP-A or Surfactant (Surf) from patients with pulmonary alveolar proteinosis (PAP) can affect the release of two chemokines (interleukin (IL)-8 and monocyte chemtactic peptide (MCP)-1) from human monocytes and rat lung type-II cells [1].
• We examined food intake, weight gain, the food efficiency ratio, degree of azotemia, and renal function in chronically azotemic rats pair-fed for 6 weeks either a vitamin B6-deficient diet or a diet containing a surfeit of vitamin B6 [2].
• Renal TZR density was not altered by sodium deficit (with increased plasma aldosterone concentration), by sodium surfeit (8% NaCl content of diet), by potassium deficit (with hypokalemia), or by potassium surfeit (drinking 1% KCl solution) [3].

High impact information on Surf1

• These results indicate that the nephron can respond rapidly to changes in the intake of amino acids, conserving taurine in periods of nutrient lack and excreting excess taurine within 4 h in periods of surfeit [4].
• Both have been proposed as mechanisms of altered energy expenditure during states of dietary energy surfeit and deficit [5].
• The results of these experiments provide support for both the Deficit and Surfeit Hypotheses of ethanol consumption, both of which suggest that endogenous opioid receptors are responsible, in part, for ethanol's reinforcing properties [6].
• The surfeit caloric intake resulted in increased carcass adiposity [7].
• The relationship between surfeit caloric consumption during intravenous infusion of a parenteral nutrition solution providing 100% daily caloric needs (PN-100; glucose:fat:amino acid = 50:30:20), carcass adiposity, and postinfusion food intake was evaluated [7].

Biological context of Surf1

• Brown Adipose Tissue (BAT) is thought to maintain caloric homeostasis by increasing its metabolic rate during periods of energy surfeit or low environmental temperatures and decreasing it during periods of deprivation or high environmental temperatures [8].

Anatomical context of Surf1

• The process of adipose differentiation uniquely endows fat cells to accrue triacylglycerols under conditions of nutrient energy surfeit and to release fatty acids during energy deprivation [9].

Associations of Surf1 with chemical compounds

• Surfeit calories during parenteral nutrition influences food intake and carcass adiposity in rats [7].

References