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Gene Review

MICAL1  -  microtubule associated monooxygenase,...

Homo sapiens

Synonyms: DKFZp434B1517, FLJ11937, FLJ21739, MICAL, MICAL-1, ...
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High impact information on MICAL1


Biological context of MICAL1

  • In contrast Hb Trout I represents a unique case of slow chemical exchange, which may depend on unusual stereoche mical characteristics of the chloride binding site; chloride binding is pH independent, but shows a significant oxygen linkage, which may be attributed to changes of the lifetime of chloride at the binding site [4].

Anatomical context of MICAL1


Associations of MICAL1 with chemical compounds

  • MICAL could act either indirectly, causing a local increase in the concentration of reactive oxygen species (ROS), or directly, inducing redox changes in downstream effectors, such as actin and members of the Rho and Rac family of guanosine triphosphatases [6].

Physical interactions of MICAL1


Co-localisations of MICAL1

  • MICAL is a cytoplasmic protein and colocalizes with CasL at the perinuclear area [2].

Other interactions of MICAL1


Analytical, diagnostic and therapeutic context of MICAL1


  1. New frontiers in structural flavoenzymology. De Colibus, L., Mattevi, A. Curr. Opin. Struct. Biol. (2006) [Pubmed]
  2. MICAL, a novel CasL interacting molecule, associates with vimentin. Suzuki, T., Nakamoto, T., Ogawa, S., Seo, S., Matsumura, T., Tachibana, K., Morimoto, C., Hirai, H. J. Biol. Chem. (2002) [Pubmed]
  3. The MICAL proteins and rab1: a possible link to the cytoskeleton? Fischer, J., Weide, T., Barnekow, A. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  4. Nuclear Magnetic resonance quadrupole relaxation studies of chloride binding to the isolated hemoglobins from trout (Salmo irideus). Chiancone, E., Norne, J.E., Forsén, S., Brunori, M., Antonini, E. Biophys. Chem. (1975) [Pubmed]
  5. MICAL-1 isoforms, novel rab1 interacting proteins. Weide, T., Teuber, J., Bayer, M., Barnekow, A. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  6. Semaphorins: green light for redox signaling? Ventura, A., Pelicci, P.G. Sci. STKE (2002) [Pubmed]
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