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Gene Review

Hrh1  -  histamine receptor H1

Mus musculus

Synonyms: Bphs, H1R, HH1R, Hir, Histamine H1 receptor
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Disease relevance of Hrh1


Psychiatry related information on Hrh1


High impact information on Hrh1


Chemical compound and disease context of Hrh1


Biological context of Hrh1


Anatomical context of Hrh1


Associations of Hrh1 with chemical compounds


Physical interactions of Hrh1


Other interactions of Hrh1


Analytical, diagnostic and therapeutic context of Hrh1


  1. Analysis of the role of Bphs/Hrh1 in the genetic control of responsiveness to pertussis toxin. Gao, J.F., Call, S.B., Fillmore, P.D., Watanabe, T., Meeker, N.D., Teuscher, C. Infect. Immun. (2003) [Pubmed]
  2. Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T-cell receptor beta-chain gene on mouse chromosome 6. Sudweeks, J.D., Todd, J.A., Blankenhorn, E.P., Wardell, B.B., Woodward, S.R., Meeker, N.D., Estes, S.S., Teuscher, C. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  3. Involvement of hypothalamic histamine H1 receptor in the regulation of feeding rhythm and obesity. Masaki, T., Chiba, S., Yasuda, T., Noguchi, H., Kakuma, T., Watanabe, T., Sakata, T., Yoshimatsu, H. Diabetes (2004) [Pubmed]
  4. Tripelennamine enhances buprenorphine-, but not pentazocine-induced hyperactivity in mice. Sansone, M., Castellano, C., Libri, V. Psychopharmacology (Berl.) (1988) [Pubmed]
  5. Compound 48/80, a histamine-depleting agent, blocks the protective effect of morphine against electroconvulsive shock in mice. Karadag, C.H., Dokmeci, D., Dost, T., Ulugol, A., Dokmeci, I. Braz. J. Med. Biol. Res. (2000) [Pubmed]
  6. Histamine H1 receptor-mediated guanosine 3',5'-monophosphate formation by cultured mouse neuroblastoma cells. Richelson, E. Science (1978) [Pubmed]
  7. Neurotransmitter receptors mediate cyclic GMP formation by involvement of arachidonic acid and lipoxygenase. Snider, R.M., McKinney, M., Forray, C., Richelson, E. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  8. T-cell suppression and contrasuppression induced by histamine H2 and H1 receptor agonists, respectively. Siegel, J.N., Schwartz, A., Askenase, P.W., Gershon, R.K. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  9. Role of histamine H1 and H2 receptor antagonists in the prevention of intimal thickening. Miyazawa, N., Watanabe, S., Matsuda, A., Kondo, K., Hashimoto, H., Umemura, K., Nakashima, M. Eur. J. Pharmacol. (1998) [Pubmed]
  10. Desensitization of histamine H1 receptor-mediated cyclic GMP formation in mouse neuroblastoma cells. Taylor, J.E., Richelson, E. Mol. Pharmacol. (1979) [Pubmed]
  11. Antihistaminics enhance morphine-, but not amphetamine- and scopolamine-induced hyperactivity in mice. Sansone, M., D'Udine, B., Renzi, P., Vetulani, J. Psychopharmacology (Berl.) (1987) [Pubmed]
  12. Effect of olopatadine and other histamine H1 receptor antagonists on the skin inflammation induced by repeated topical application of oxazolone in mice. Tamura, T., Masaki, S., Ohmori, K., Karasawa, A. Pharmacology (2005) [Pubmed]
  13. The effect of fexofenadine on pruritus in a mouse model (HR-ADf) of atopic dermatitis. Akamatsu, H., Makiura, M., Yamamoto, N., Yagami, A., Shimizu, Y., Matsunaga, K. J. Int. Med. Res. (2006) [Pubmed]
  14. Targeted disruption of histamine H1-receptor attenuates regulatory effects of leptin on feeding, adiposity, and UCP family in mice. Masaki, T., Yoshimatsu, H., Chiba, S., Watanabe, T., Sakata, T. Diabetes (2001) [Pubmed]
  15. Identification of Bphs, an autoimmune disease locus, as histamine receptor H1. Ma, R.Z., Gao, J., Meeker, N.D., Fillmore, P.D., Tung, K.S., Watanabe, T., Zachary, J.F., Offner, H., Blankenhorn, E.P., Teuscher, C. Science (2002) [Pubmed]
  16. Chemical genetic identification of the histamine H1 receptor as a stimulator of insulin-induced adipogenesis. Kawazoe, Y., Tanaka, S., Uesugi, M. Chem. Biol. (2004) [Pubmed]
  17. Differences in the adenosine receptors modulating inositol phosphates and cyclic AMP accumulation in mammalian cerebral cortex. Alexander, S.P., Kendall, D.A., Hill, S.J. Br. J. Pharmacol. (1989) [Pubmed]
  18. Design, synthesis and pharmacological screening of a series of N1-(substituted) aryl-5,7-dimethyl-2-(substituted)pyrido(2,3-d)-pyrimidin-4(3H)-ones as potential histamine H1-receptor antagonists. Suhagia, B.N., Chhabria, M.T., Makwana, A.G. Journal of enzyme inhibition and medicinal chemistry (2006) [Pubmed]
  19. Improvement by FUB 181, a novel histamine H3-receptor antagonist, of learning and memory in the elevated plus-maze test in mice. Onodera, K., Miyazaki, S., Imaizumi, M., Stark, H., Schunack, W. Naunyn Schmiedebergs Arch. Pharmacol. (1998) [Pubmed]
  20. The influence of histamine at various concentrations on the cell cycle state of hematopoietic stem cells (CFU-s). Yi, S.N., Xu, Y.H. Int. J. Cell Cloning (1988) [Pubmed]
  21. Histamine-induced microvascular leakage in pial venules: differences between the SJL/J and BALB/c inbred strains of mice. Yong, T., Bebo, B.F., Sapatino, B.V., Welsh, C.J., Orr, E.L., Linthicum, D.S. J. Neurotrauma (1994) [Pubmed]
  22. Histamine H1 receptors are involved in mouse nasal allergic responses: a demonstration with H1 receptor-deficient mice. Kayasuga, R., Sugimoto, Y., Watanabe, T., Kamei, C. Int. Immunopharmacol. (2002) [Pubmed]
  23. Histamine H1 and H2 receptor antagonists accelerate skin barrier repair and prevent epidermal hyperplasia induced by barrier disruption in a dry environment. Ashida, Y., Denda, M., Hirao, T. J. Invest. Dermatol. (2001) [Pubmed]
  24. Proto-oncogene fos (c-fos) expression in the heart. Barka, T., van der Noen, H., Shaw, P.A. Oncogene (1987) [Pubmed]
  25. Histamine H1 receptor binding sites in mouse uterine horns. Gonzalez, R., Reinicke, K., Rudolph, G.M. Gen. Pharmacol. (1993) [Pubmed]
  26. Enhanced antinociception by intracerebroventricularly administered orexin A in histamine H1 or H2 receptor gene knockout mice. Mobarakeh, J.I., Takahashi, K., Sakurada, S., Nishino, S., Watanabe, H., Kato, M., Naghdi, N., Yanai, K. Pain (2005) [Pubmed]
  27. Development of amygdaloid kindling in histidine decarboxylase-deficient and histamine H1 receptor-deficient mice. Hirai, T., Okuma, C., Harada, C., Mio, M., Ohtsu, H., Watanabe, T., Kamei, C. Epilepsia (2004) [Pubmed]
  28. Attenuation of Th1 effector cell responses and susceptibility to experimental allergic encephalomyelitis in histamine H2 receptor knockout mice is due to dysregulation of cytokine production by antigen-presenting cells. Teuscher, C., Poynter, M.E., Offner, H., Zamora, A., Watanabe, T., Fillmore, P.D., Zachary, J.F., Blankenhorn, E.P. Am. J. Pathol. (2004) [Pubmed]
  29. Physical mapping of the autoimmune disease susceptibility locus, Bphs: co-localization with a cluster of genes from the TNF receptor superfamily on mouse chromosome 6. Meeker, N.D., Stafford, A.N., Lunceford, J.K., Avner, P., Ma, R.Z., Teuscher, C. Mamm. Genome (1999) [Pubmed]
  30. Characteristics of the mouse genomic histamine H1 receptor gene. Inoue, I., Taniuchi, I., Kitamura, D., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Watanabe, T. Genomics (1996) [Pubmed]
  31. Antidepressant-like effects of endogenous histamine and of two histamine H1 receptor agonists in the mouse forced swim test. Lamberti, C., Ipponi, A., Bartolini, A., Schunack, W., Malmberg-Aiello, P. Br. J. Pharmacol. (1998) [Pubmed]
  32. (N-methyl-[11C])pyrilamine, a radiotracer for histamine H-1 receptors: radiochemical synthesis and biodistribution study in mice. Yanai, K., Dannals, R.F., Wilson, A.A., Ravert, H.T., Scheffel, U., Tanada, S., Wagner, H.N. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology. (1988) [Pubmed]
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