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Gene Review

Cldn3  -  claudin 3

Rattus norvegicus

Synonyms: Claudin-3, RVP1, Rat ventral prostate.1 protein
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High impact information on Cldn3

  • In the pancreas, claudin 2 is only detected in junctions of the duct epithelia, claudin 5 only in junctions of acinar cells, whereas claudin 3 and 4 are in both [1].
  • This study investigates the effect in the rat of chronic CdCl2 intoxication (500 microg Cd2+/kg, daily i.p. injection for 5 days) on renal function and the changes in tight junction proteins claudin-2, claudin-3, and claudin-5 present in rat kidney [2].
  • Claudin-3 and claudin-4 were also co-expressed by some alveolar epithelial cells adjacent to type II cells [3].
  • Additionally, the tight junctional protein occludin had a shift in bands that correlated with functional changes (i.e., increased permeability) without significant change in expression of claudin-3, zonula occludens-1, or actin [4].
  • Though no changes in total protein expression were observed, nicotine treatment was associated with altered cellular distribution of ZO-1 and diminished junctional immunoreactivity of claudin-3 [5].

Associations of Cldn3 with chemical compounds

  • However, methanandamide-treated cells showed a 12-fold increase in claudin-5 expression and a 2- to 3-fold increase in claudin-3, consistent with the notion that specific changes in claudin expression levels may correlate with changes in alveolar epithelial barrier function [3].

Analytical, diagnostic and therapeutic context of Cldn3


  1. Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut. Rahner, C., Mitic, L.L., Anderson, J.M. Gastroenterology (2001) [Pubmed]
  2. Zinc protects renal function during cadmium intoxication in the rat. Jacquillet, G., Barbier, O., Cougnon, M., Tauc, M., Namorado, M.C., Martin, D., Reyes, J.L., Poujeol, P. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
  3. Heterogeneity of claudin expression by alveolar epithelial cells. Wang, F., Daugherty, B., Keise, L.L., Wei, Z., Foley, J.P., Savani, R.C., Koval, M. Am. J. Respir. Cell Mol. Biol. (2003) [Pubmed]
  4. Effects of hypoxia-reoxygenation on rat blood-brain barrier permeability and tight junctional protein expression. Witt, K.A., Mark, K.S., Hom, S., Davis, T.P. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]
  5. Nicotine increases in vivo blood-brain barrier permeability and alters cerebral microvascular tight junction protein distribution. Hawkins, B.T., Abbruscato, T.J., Egleton, R.D., Brown, R.C., Huber, J.D., Campos, C.R., Davis, T.P. Brain Res. (2004) [Pubmed]
  6. Analysis of a human gene homologous to rat ventral prostate.1 protein. Peacock, R.E., Keen, T.J., Inglehearn, C.F. Genomics (1997) [Pubmed]
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